Yaping Yan, Tengkun Dai, Mengmeng Guo, Xu Zhao, Chao Chen, Ya Zhou, Ming Qin, Lin Xu, Juanjuan Zhao
Mitogen-Activated Protein Kinases (MAPKs) are serine/threonine protein kinases that play a crucial role in transmitting extracellular signals to the intracellular environment, influencing a wide range of cellular processes including proliferation, differentiation, apoptosis, metabolic activities, immune function and stress response. MAPK4, a non-classical MAPK, is frequently overexpressed in various malignancies, including prostate, breast, cervix, thyroid, and gliomas. It orchestrates cell proliferation, migration, and apoptosis via the AKT/mTOR and/or PDK1 signaling pathways, thus facilitating tumor cell growth...
May 25, 2024: International Journal of Biological Macromolecules