Stacie K Totsch, Andrew S Ishizuka, Kyung-Don Kang, Sam E Gary, Abbey Rocco, Aaron E Fan, Li Zhou, Pablo A Valdes, SeungHo Lee, Jason Li, Luca Peruzzotti-Jametti, Sarah Blitz, Christopher M Garliss, James M Johnston, James M Markert, Geoffrey M Lynn, Joshua D Bernstock, Gregory K Friedman
PURPOSE: Oncolytic virotherapy or immunovirotherapy is a strategy that utilizes viruses to selectively infect and kill tumor cells while also stimulating an immune response against the tumor. Early clinical trials in both pediatric and adult patients using oncolytic herpes simplex viruses (oHSVs) have demonstrated safety and promising efficacy; however, combinatorial strategies designed to enhance oncolysis while also promoting durable T cell responses for sustaining disease remission are likely required...
May 6, 2024: Molecular Cancer Therapeutics