Hafez Al-Momani, Audrey Perry, Andrew Nelson, Christopher J Stewart, Rhys Jones, Amaran Krishnan, Andrew Robertson, Stephen Bourke, Simon Doe, Stephen Cummings, Alan Anderson, Tara Forrest, Ian Forrest, Michael Griffin, Matthew Wilcox, Malcolm Brodlie, Jeffrey Pearson, Christopher Ward
Studies of microbiota reveal inter-relationships between the microbiomes of the gut and lungs. This relationship may influence the progression of lung disease, particularly in patients with cystic fibrosis (CF), who often experience extraoesophageal reflux (EOR). Despite identifying this relationship, it is not well characterised. Our hypothesis is that the gastric and lung microbiomes in CF are related, with the potential for aerodigestive pathophysiology. We evaluated gastric and sputum bacterial communities by culture and 16S rRNA gene sequencing in 13 CF patients...
June 30, 2022: Scientific Reports