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REVIEW
Tom Hartmann, Martin Middendorf, Matthias Bernt
Genome rearrangements are mutations that change the gene content of a genome or the arrangement of the genes on a genome. Several years of research on genome rearrangements have established different algorithmic approaches for solving some fundamental problems in comparative genomics based on gene order information. This review summarizes the literature on genome rearrangement analysis along two lines of research. The first line considers rearrangement models that are particularly well suited for a theoretical analysis...
2024: Methods in Molecular Biology
#2
JOURNAL ARTICLE
Patrik Pöschke, Paul Gass, Annika Krückel, Katharina Keller, Ramona Erber, Arndt Hartmann, Matthias W Beckmann, Julius Emons
INTRODUCTION: The medical and surgical treatment of endometrial cancer (EC) is evolving toward a more patient-centered and personalized approach. The role of laparoscopic sentinel node biopsy (SNB) for early-stage EC is unclear, and very few data are available for atypical endometrial hyperplasia (AEH). The present study investigated the effectiveness of SNB combined with laparoscopic hysterectomy in patients with early-stage EC and AEH. PATIENTS AND METHODS: This was a retrospective, single-center cohort study for the period from January 2018 to December 2023...
May 2024: Geburtshilfe und Frauenheilkunde
#3
JOURNAL ARTICLE
Patricia M Davis, Eugene Ravkov, Martina de Geus, Zach Clauss, John Lee, Anh Tuan Nguyen, Marsha Hartmann, Jeffrey Kim, Tracy I George, Leo Lin, David P Ng
Clinical flow cytometry laboratories require quality control materials for assay development, validation, and performance monitoring, including new reagent lot qualification. However, finding suitable controls for populations with uncommonly expressed antigens or for rare populations, such as mast cells, can be difficult. To that end, we evaluated synthetic abnormal mast cell particles (SAMCP), developed together with, and manufactured by, Slingshot Biosciences. The SAMCP's were designed to phenotypically mimic abnormal neoplastic mast cells: they were customized to have the same light scatter and autofluorescence properties of mast cells, along with surface antigen levels of CD45, CD33, CD117, CD2, CD25, and CD30 consistent with that seen in mast cell disease...
May 30, 2024: Cytometry. Part B, Clinical Cytometry
#4
JOURNAL ARTICLE
Michael Olbrich, Adina-Malin Hartmann, Sven Künzel, Zouhair Aherrahrou, Paul Schilf, John F Baines, Saleh M Ibrahim, Misa Hirose
We previously demonstrated that mice carrying natural mtDNA variants of the FVB/NJ strain (m.7778G>T in the mt-Atp8 gene in mitochondrial complex V), namely C57BL/6J-mtFVB/NJ (B6-mtFVB), exhibited (i) partial protection from experimental skin inflammatory diseases in an anti-murine type VII collagen antibody-induced skin inflammation model and psoriasiform dermatitis model; (ii) significantly altered metabolites, including short-chain fatty acids, according to targeted metabolomics of liver, skin and lymph node samples; and (iii) a differential composition of the gut microbiota according to bacterial 16S rRNA gene sequencing of stool samples compared to wild-type C57BL/6J (B6) mice...
May 28, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
#5
JOURNAL ARTICLE
Carmen K Dietrich, Tobias Hirsch, Karsten Hartmann, Thomas Mattausch, Hans-Christian Wenzel, Philipp Zollmann, Jürgen Veltman, Thomas K Weiler, Guido Lengfellner, Lars Müller, Markus Stücker, Felizitas Pannier, Lorenz Uhlmann, Christine Müller-Christmann
BACKGROUND: The SYNCHRONOUS-study investigates simultaneous ASV-ablation with great saphenous vein (GSV) treatment in endovenous laser ablation (EVLA) for preventing varicose vein recurrence. This sub-study examines complication rates associated with prophylactic ASV-ablation. METHODS: Among 1173 patients with refluxing GSV, 604 underwent GSV-ablation only, and 569 received additional ASV-ablation. Complication rates were compared over 6 months. RESULTS: Approximately 80% of patients were complication-free with minor bruising and dysesthesia being most common complications...
May 30, 2024: Phlebology
#6
JOURNAL ARTICLE
Magdalena Buckert, Carmen Streibel, Mechthild Hartmann, Nelly Monzer, Stefan Kopf, Julia Szendrödi, Beate Wild
INTRODUCTION: Increasing evidence supports chronic psychological stress as a risk factor for the development of type 2 diabetes. Much less is known, however, about the role of chronic stress in established diabetes. METHODS: The aim of the current study was to comprehensively assess chronic stress in a sample of 73 patients with type 2 diabetes and 48 non-diabetic control participants, and to investigate associations with indicators of glycemic control (HbA1c), insulin resistance (HOMA-IR), β-cell functioning (C-peptide), illness duration, and the presence of microvascular complications...
2024: Frontiers in Public Health
#7
RANDOMIZED CONTROLLED TRIAL
Charlotta Thunborg, Rui Wang, Anna Rosenberg, Shireen Sindi, Pia Andersen, Sandrine Andrieu, Laus M Broersen, Nicola Coley, Celine Couderc, Celine Z Duval, Gerd Faxen-Irving, Göran Hagman, Merja Hallikainen, Krister Håkansson, Eija Kekkonen, Jenni Lehtisalo, Nicholas Levak, Francesca Mangialasche, Johannes Pantel, Anders Rydström, Anna Stigsdotter-Neely, Anders Wimo, Tiia Ngandu, Hilkka Soininen, Tobias Hartmann, Alina Solomon, Miia Kivipelto
BACKGROUND: The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) showed cognitive benefits from a multidomain lifestyle intervention in at-risk older people. The LipiDiDiet trial highlighted benefits of medical food in prodromal Alzheimer's disease (AD). However, the feasibility and impact of multimodal interventions combining lifestyle with medical food in prodromal AD is unclear. METHODS: MIND-ADmini was a 6-month multinational (Sweden, Finland, Germany, France) proof-of-concept randomized controlled trial (RCT)...
May 30, 2024: Alzheimer's Research & Therapy
#8
Ralf Otto-Knapp, Torsten Bauer, Folke Brinkmann, Cornelia Feiterna-Sperling, Inna Friesen, Hilte Geerdes-Fenge, Pia Hartmann, Brit Haecker, Jan Heyckendorf, Martin Kuhns, Christoph Lange, Florian P Maurer, Albert Nienhaus, Martin Priwitzer, Elvira Richter, Helmut J F Salzer, Otto D Schoch, Nicolas Schoenfeld, Tom Schaberg
Based on the assessment of new evidence, the World Health Organization (WHO) updated its guidelines for the treatment of drug-resistant tuberculosis (TB) in December 2022. The new recommendations and the latest study data made it necessary to update the existing guideline on the treatment of at least rifampicin- (RR-TB) for the German-speaking countries, replacing the respective chapters of the treatment guidelines published 2022. A shortened treatment of proven RR-TB and multidrug-resistant (MDR)-TB for at least 6 months using the fixed and non-modifiable drug combination of bedaquiline, pretomanid, linezolid, and moxifloxacin (BPaLM) is now also recommended for Austria, Germany, and Switzerland under certain conditions considering the existing barriers for the implementation of the new treatment regimen...
May 29, 2024: Respiration; International Review of Thoracic Diseases
#9
JOURNAL ARTICLE
Alexander Gurjanov, Lea A I Vaas, Thomas Steger-Hartmann
Virtual control groups (VCGs) created from historical control data (HCD) can reduce the number of concurrent control group animals needed in regulatory toxicity studies by up to 25%. This study investigates the performance of VCGs on statistical outcomes of body weight development between treatment and control groups in legacy studies. The objective is to reproduce the statistical outcomes of 28-day sub-chronic studies (legacy studies) after replacing the concurrent control group with virtual ones. In rodent toxicity studies initial body weight is used as surrogate for the age of animals...
May 22, 2024: ALTEX
#10
JOURNAL ARTICLE
Dongsheng Li, Jiayin Dong, Haibin Li
This research examines the electromagnetohydrodynamic (EMHD) flow of Jeffrey fluid in a rough circular microchannel while considering the effect of surface charge on slip. The channel wall corrugations are described as periodic sinusoidal waves with small amplitudes. The perturbation method is employed to derive solutions for velocity and volumetric flow rate, and a combination of three-dimensional (3D) and two-dimensional (2D) graphical representations is utilized to effectively illustrate the impacts of relevant parameters on them...
May 29, 2024: Electrophoresis
#11
JOURNAL ARTICLE
Markus Müller, Nian Liu, Vipul Gujrati, Abha Valavalkar, Sean Hartmann, Pia Anzenhofer, Uwe Klemm, András Telek, Benjamin Dietzek-Ivanšić, Achim Hartschuh, Vasilis Ntziachristos, Oliver Thorn-Seshold
Optoacoustic (or photoacoustic) imaging promises micron-resolution noninvasive bioimaging with much deeper penetration (>cm) than fluorescence. However, optoacoustic imaging of enzyme activity would require loud, photostable, NIR-absorbing molecular contrast agents: which remain unknown. Most organic molecular contrast agents are repurposed fluorophores, with severe shortcomings of photoinstability or phototoxicity under optoacoustic imaging, as consequences of their slow S1→S0 electronic relaxation...
May 28, 2024: Angewandte Chemie
#12
JOURNAL ARTICLE
Diana Diaz, Kensey Bergdorf, Matthew A Loberg, Courtney J Phifer, George J Xu, Quanhu Sheng, Sheau-Chiann Chen, Jamal M Byrant, Megan L Tigue, Heather Hartmann, Sarah L Rohde, James L Netterville, Naira Baregamian, Jeremy A Goettel, Fei Ye, Ethan Lee, Vivian L Weiss
BACKGROUND: Anaplastic thyroid carcinoma (ATC) is a highly aggressive malignancy that has consistently shown Wnt/β-catenin (canonical) signaling activation in various study populations. There are currently no targetable treatments for BRAF-wildtype ATC and a lack of effective treatment for BRAFV600E ATC. Our aim is to identify whether Wnt inhibitors could be potential therapeutic agents for ATC patients with limited treatment options. METHODS: In this Institutional Review Board-approved study, we utilize a cohort of 32 ATCs and 20 non-neoplastic multinodular goiters (MNG)...
May 28, 2024: Endocrine
#13
JOURNAL ARTICLE
Linda M A Lehmanski, Lara M Kösters, Jianbei Huang, Martin Göbel, Jonathan Gershenzon, Henrik Hartmann
With the increasing frequencies of extreme weather events caused by climate change, the risk of forest damage from insect attacks grows. Storms and droughts can damage and weaken trees, reduce tree vigour and defence capacity and thus provide host trees that can be successfully attacked by damaging insects, as often observed in Norway spruce stands attacked by the Eurasian spruce bark beetle Ips typographus. Following storms, partially uprooted trees with grounded crowns suffer reduced water uptake and carbon assimilation, which may lower their vigour and decrease their ability to defend against insect attack...
2024: PloS One
#14
JOURNAL ARTICLE
Lu-Chen Weng, Shaan Khurshid, Amelia Weber Hall, Victor Nauffal, Valerie N Morrill, Yan V Sun, Joel T Rämö, Dominik Beer, Simon Lee, Girish Nadkarni, Renee Johnson, Laura Andreasen, Anne Clayton, Clive R Pullinger, Zachary T Yoneda, Daniel J Friedman, Matthew C Hyman, Renae L Judy, Allan C Skanes, Kate M Orland, Paloma Jordà, Timothy M Treu, Matthew T Oetjens, Rajesh Subbiah, Jacob P Hartmann, Heidi T May, John P Kane, Tariq Z Issa, Navid A Nafissi, Peter Leong-Sit, Marie-Pierre Dubé, Carolina Roselli, Seung Hoan Choi, Jean-Claude Tardif, Habib R Khan, Stacey Knight, Jesper H Svendsen, Bruce Walker, Richard Karlsson Linnér, J Michael Gaziano, Rafik Tadros, Diane Fatkin, Daniel J Rader, Svati H Shah, Dan M Roden, Gregory M Marcus, Ruth J F Loos, Scott M Damrauer, Christopher M Haggerty, Kelly Cho, Aarno Palotie, Morten S Olesen, Lee L Eckhardt, Jason D Roberts, Michael J Cutler, M Benjamin Shoemaker, Peter W F Wilson, Patrick T Ellinor, Steven A Lubitz
BACKGROUND: Substantial data support a heritable basis for supraventricular tachycardias, but the genetic determinants and molecular mechanisms of these arrhythmias are poorly understood. We sought to identify genetic loci associated with atrioventricular nodal reentrant tachycardia (AVNRT) and atrioventricular accessory pathways or atrioventricular reciprocating tachycardia (AVAPs/AVRT). METHODS: We performed multiancestry meta-analyses of genome-wide association studies to identify genetic loci for AVNRT (4 studies) and AVAP/AVRT (7 studies)...
May 28, 2024: Circulation. Genomic and Precision Medicine
#15
JOURNAL ARTICLE
Katrine Top Hartmann, Regitze Lund Nielsen, Freja Cecilie Mikkelsen, Bent Aalbæk, Mads Lichtenberg, Tim Holm Jakobsen, Thomas Bjarnsholt, Lasse Kvich, Hanne Ingmer, Anders Odgaard, Henrik Elvang Jensen, Louise Kruse Jensen
Is it time to rethink the inoculum of animal models of implant-associated infections (IAI)? Traditionally, animal models of IAI are based on inoculation with metabolically active overnight cultures of planktonic bacteria or pre-grown surface-attached biofilms. However, such inoculums do not mimic the clinical initiation of IAI. Therefore, the present study aimed to develop a clinically relevant inoculum of low metabolic micro-aggregated bacteria. The porcine Staphylococcus aureus strain S54F9 was cultured in Tryptone Soya Broth (TSB) for seven days to facilitate the formation of low metabolic micro-aggregates...
June 2024: Biofilm
#16
JOURNAL ARTICLE
Elin Mariusdottir, Fredrik Jörgren, Marie-Louise Lydrup, Pamela Buchwald
AIM: There is ongoing controversy regarding the extent to which Hartmann's procedure (HP) should be used in rectal cancer treatment. This study was designed to investigate 30-day postoperative morbidity and mortality following HP, anterior resection (AR) and abdominoperineal resection (APR) for rectal cancer using a national registry. METHODS: All patients operated for rectal cancer, tumour height 5-15 cm, between the years 2010 and 2017, were identified through the Swedish colorectal cancer registry...
May 27, 2024: Colorectal Disease
#17
JOURNAL ARTICLE
Andreas Joos, Stoyan Popkirov, Claas Lahmann, Michael Jöbges, Christoph Herrmann, Philipp Maner, Kai Schörner, Gunnar Birke, Armin Hartmann
INTRODUCTION: Illness perception refers to patients' subjective representations and appraisals of somatic and mental symptoms. These are relevant for self-management and outcome. In clinical practice, patients with functional neurological disorder (FND) often encounter a fragmented biomedical attitude, which leaves them without clear concepts. In this context, illness perception is relevant. METHODS: Illness perception was assessed in FND patients and compared with samples of psychosomatic patients (PSM) as well as poststroke patients (STR)...
2024: BMJ neurology open
#18
JOURNAL ARTICLE
Todor Tschongov, Swagata Konwar, Andreas Busch, Christian Sievert, Andrea Hartmann, Marina Noris, Sara Gastoldi, Sistiana Aiello, Andreas Schaaf, Jens Panse, Peter F Zipfel, Paulina Dabrowska-Schlepp, Karsten Häffner
Most drugs that target the complement system are designed to inhibit the complement pathway at either the proximal or terminal levels. The use of a natural complement regulator such as factor H (FH) could provide a superior treatment option by restoring the balance of an overactive complement system while preserving its normal physiological functions. Until now, the systemic treatment of complement-associated disorders with FH has been deemed unfeasible, primarily due to high production costs, risks related to FH purified from donors' blood, and the challenging expression of recombinant FH in different host systems...
2024: Frontiers in Immunology
#19
JOURNAL ARTICLE
Larissa Oser, Ankur Midha, Josephine Schlosser-Brandenburg, Sebastian Rausch, Robert M Mugo, Arkadi Kundik, Luis E Elizalde-Velázquez, Joshua Adjah, Zaneta D Musimbi, Robert Klopfleisch, Christina S Helm, Georg von Samson-Himmelstjerna, Susanne Hartmann, Friederike Ebner
Ascaris spp. undergo extensive migration within the body before establishing patent infections in the small intestinal tract of humans and pigs. However, whether larval migration is critical for inducing efficient type 2 responses remains poorly understood. Therefore, we investigated systemic versus local adaptive immune responses along the hepato-tracheal migration of Ascaris suum during primary, single infections in conventionally raised pigs. Neither the initial invasion of gut tissue nor migration through the liver resulted in discernable Th2 cell responses...
2024: Frontiers in Immunology
#20
Stella Hartmann, Lisa Radochonski, Chengjin Ye, Luis Sobrido-Martinez, Jueqi Chen
SARS-CoV-2 uses the double-membrane vesicles as replication organelles. However, how virion assembly occurs has not been fully understood. Here we identified a SARS-CoV-2-driven membrane structure named the 3a dense body (3DB). 3DBs have unusual electron-dense and dynamic inner structures, and their formation is driven by the accessory protein ORF3a via hijacking a specific subset of the trans-Golgi network (TGN) and early endosomal membranes. 3DB formation is conserved in related bat and pangolin coronaviruses yet lost during the evolution to SARS-CoV...
May 17, 2024: Research Square
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