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https://read.qxmd.com/read/30872337/anti-amphiphysin-associated-limbic-encephalitis-in-a-72-year-old-patient-with-aortic-angiosarcoma
#1
Tobias A Wagner-Altendorf, Klaus-Peter Wandinger, Alex Frydrychowicz, Axel S Merseburger, Thomas F Münte
Paraneoplastic autoimmune encephalopathic syndromes have been described most often in association with small cell lung cancer or breast cancer, tumours of the ovaries, testes, lymphoma and thymoma. Antibodies associated with paraneoplastic encephalopathies are, among others, anti-Hu, anti-Ma2 and, in part, anti-N-methyl-D-aspartate(NMDA)-receptor antibodies. Here, we present the case of a 72-year-old patient hospitalised due to progressive cognitive decline and disorientation. Diagnostic workup revealed paraneoplastic anti-amphiphysin associated limbic encephalitis on the basis of an aortic angiosarcoma with metastases to kidney, muscle and bones...
March 14, 2019: BMJ Case Reports
https://read.qxmd.com/read/30867573/paraneoplastic-neurological-syndromes-in-the-era-of-immune-checkpoint-inhibitors
#2
REVIEW
Francesc Graus, Josep Dalmau
Paraneoplastic neurological syndromes (PNSs) comprise a group of disorders that can affect any part of the nervous system in patients with cancer and frequently result from autoimmune responses triggered by the ectopic expression of neuronal proteins in cancer cells. These disorders are rare, although the introduction of immune-checkpoint inhibitors (ICIs) into cancer treatment algorithms has renewed interest in PNSs. ICIs are associated with a considerably increased incidence of immunological toxicities compared with traditional anticancer therapies, including neurological immune-related adverse effects (nirAEs) that can manifest as PNSs...
March 12, 2019: Nature Reviews. Clinical Oncology
https://read.qxmd.com/read/30843116/cancer-and-motor-neuron-disease-causal-or-coincidental-two-contrasting-cases
#3
John Goodfellow, George Gorrie, Veronica Leach, Sameer Patel, Graham Mackay
INTRODUCTION: Motor neuron disease (MND) can occur in patients with cancer, but there is minimal evidence that this is more than by chance. We contrast two cases of motor neuronopathies occurring in the context of systemic malignancy and argue that in one case the cause was most likely paraneoplastic, while in the other it was not. CASE 1: A 61-year-old woman developed progressive walking difficulties over 9 months with weakness and stiffness in her legs. EMG showed fibrillations and positive sharp waves in multiple lower limb muscles bilaterally, with neurogenic units and a reduced recruitment pattern...
March 6, 2019: Neurological Sciences
https://read.qxmd.com/read/30810271/paraneoplastic-autoimmunity-and-small-cell-lung-cancer-neurological-and-serological-accompaniments
#4
Anastasia Zekeridou, Masoud Majed, Ioannis Heliopoulos, Vanda A Lennon
Paraneoplastic neurological autoimmunity is often associated with small-cell lung cancer (SCLC), a highly malignant neuroendocrine tumor. Paraneoplastic autoimmunity often correlates with longer survival. We describe the paraneoplastic neurological manifestations of patients with SCLC with and without SCLC-predictive autoantibodies and the correlation between autoimmunity and survival. We reviewed the records of 116 patients (51% male) from the Mayo Clinic with histopathologically confirmed SCLC for whom stored serum was available for neural autoantibody testing...
February 27, 2019: Thoracic Cancer
https://read.qxmd.com/read/30799422/a-rare-case-of-mixed-adenoneuroendocrine-carcinoma-manec-of-the-gastroesophageal-junction-with-her2-neu-overexpression-and-distinct-orbital-and-optic-nerve-toxicity-after-intravenous-administration-of-cisplatin
#5
Thomas Golombek, Robert Henker, Matus Rehak, Ulf Quäschling, Florian Lordick, Maren Knödler
BACKGROUND: Mixed adenoneuroendocrine carcinomas (MANECs) are rare malignancies with both neuroendocrine and non-neuroendocrine components. To date, the prognosis of gastroenteropancreatic MANECs remains dismal, and treatment options are mainly based on guidelines for the treatment of pure neuroendocrine carcinomas or small cell lung cancer. Established first-line therapy in the metastatic situation is cisplatin and etoposide. Platinum derivatives are known to cause a variety of side effects also involving the visual system...
February 23, 2019: Oncology Research and Treatment
https://read.qxmd.com/read/30792645/significance-of-earlier-initiation-of-chemotherapy-for-lung-cancer-complicated-with-primary-or-secondary-nephrotic-syndrome-following-its-appropriate-differential-diagnosis
#6
Shuji Ota, Yoshihide Fujigaki, Yoshifuru Tamura, Kenichiro Kojima, Ryosuke Ochiai, Terunobu Haruyama, Masashi Ishihara, Maika Natsume, Yoko Fukasawa, Takahiko Sakamoto, Shigeru Tanzawa, Ryo Usui, Takeshi Honda, Yasuko Ichikawa, Kiyotaka Watanabe, Nobuhiko Seki
We encountered a case of primary lung cancer complicated with membranous nephropathy as primary nephrotic syndrome. Because treatment approaches vary greatly for primary and secondary nephrotic syndrome, a renal biopsy was performed for diagnosis. Much time was required to make a definitive diagnosis of primary nephrotic syndrome, as opposed to paraneoplastic nephrotic syndrome. Consequently, the subsequent chemotherapy was ineffective and caused significant toxicity due to reduced performance status (PS) and progression of hypoalbuminemia...
January 2019: Case Reports in Oncology
https://read.qxmd.com/read/30791855/treatment-refractory-paraneoplastic-opsoclonus-myoclonus-syndrome-in-a-patient-with-small-cell-carcinoma-of-the-lung
#7
Ali Alkan, Utku Cenikli, Selçuk Uylaş, Mehmet Yılmaz, Tümay Çakır, Halil Çetinkaya, Alkan Kıran, Özgür Tanrıverdi
Opsoclonus-myoclonus syndrome is a rare disease and traditionally described as "dancing eyes, dancing feet syndrome." It is characterized by opsoclonus (oscillations of the eyes in either horizontally or vertically) and myoclonus (spontaneous jerky movements of the limbs and trunk). There are numerous etiological factors defined such as paraneoplastic, para-infectious, toxic-metabolic, and idiopathic causes. The experience of opsoclonus-myoclonus syndrome in adults is very limited. Here, we present a case of treatment-refractory paraneoplastic opsoclonus-myoclonus syndrome associated with small-cell carcinoma of the lung...
February 22, 2019: Journal of Oncology Pharmacy Practice
https://read.qxmd.com/read/30788076/cancer-associated-myositis-an-elusive-entity
#8
Beenish Fayyaz, Hafiz J Rehman, Hakim Uqdah
Inflammatory myopathies are characterized by the skeletal muscle inflammation leading to symptoms of myopathy along with varying involvement of other organs such as lung, skin and joints. The strong association between inflammatory myopathies and malignancy has been well recognized. Recently, ‘cancer-associated myositis (CAM)’, has been proposed to be a paraneoplastic syndrome due to the anti-tumor immunity secondary to similar tumor and regenerating muscle antigens. As the prognosis of myositis depends on the prognosis and treatment of the underlying malignancy, physicians must determine the degree of testing necessary to detect cancer both at myositis onset and thereafter...
2019: Journal of Community Hospital Internal Medicine Perspectives
https://read.qxmd.com/read/30755579/breast-cancer-with-paraneoplastic-syndrome-in-a-72-year-old-male-patient
#9
S Yesmin, M Sanyal, M J Hasan
Breast cancer in male is rare which accounts about 1% of all malignant breast neoplasm cases. Since paraneoplastic syndrome is unusual with male breast cancer, very few reported cases are found. A72- year-old gentleman presented with proximal myopathy in all four limbs was referred to Dr. Sirajul Islam Medical College and Hospital in April 2017. He had generalized wasting with reduced tone and reflexes. Planter responses were normal with intact sensory. There were typical Heliotrope rash bilaterally. In background, he had history of radical mastectomy due to stage IIA ductal carcinoma of left breast 7 years back...
January 2019: Mymensingh Medical Journal: MMJ
https://read.qxmd.com/read/30718446/-paraneoplastic-cerebellar-degeneration-with-lambert-eaton-myasthenic-syndrome-a-report-of-an-effectively-treated-case-and-systematic-review-of-japanese-cases
#10
Hiroko Kitanosono, Masakatsu Motomura, Hiroki Tomita, Hiroshi Iwanaga, Naoki Iwanaga, Takashi Irioka, Hirokazu Shiraishi, Akira Tsujino
A 63-year-old female who developed dizziness, diplopia and subsequent gait disturbance from September X-1 year was analyzed. The first neurological findings in May X year revealed cerebellar ataxia, weakness in the proximal limbs, decreased tendon reflexes, and autonomic symptoms (ADL:mRS 3). Furthermore, an incremental phenomenon was observed in the repetitive nerve stimulation test, and she was diagnosed with Lambert-Eaton myasthenic syndrome (LEMS) based on the serum P/Q-type calcium channel (VGCC) antibody positivity...
February 2019: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://read.qxmd.com/read/30713326/recent-updates-on-the-relationship-between-cancer-and-autoimmune-pancreatitis
#11
Ayana Okamoto, Tomohiro Watanabe, Ken Kamata, Kosuke Minaga, Masatoshi Kudo
Autoimmune pancreatitis (AIP) is now considered a pancreatic manifestation of a newly proposed disease condition, IgG4-related disease (IgG4-RD). IgG4-RD is characterized by enhanced IgG4 antibody responses and multiple organ involvements. Recent epidemiological studies have addressed the incidence of cancer in patients with AIP and/or IgG4-RD. Surprisingly, a significant number of AIP patients were detected with cancer at or within one year of the diagnosis of AIP. Furthermore, around 50% of all cancers detected in AIP patients comprised mainly 3 types (gastric, lung, and prostate cancer)...
February 1, 2019: Internal Medicine
https://read.qxmd.com/read/30661417/neuroprotective-effect-of-ilex-paraguariensis-intake-on-brain-myelin-of-lung-adenocarcinoma-bearing-male-balb-c-mice
#12
María C Cittadini, Claudia Albrecht, Agustín R Miranda, Gina M Mazzuduli, Elio A Soria, Gastón Repossi
Ilex paraguariensis (IP) is widely consumed as tea with high nutritional value. This plant contains several bioactive phenolic compounds, which are antioxidant and anti-inflammatory. On the other hand, lung adenocarcinoma (LAC) deleteriously involves neoplastic progression, inflammatory paraneoplastic syndromes, and death. Given that brain is a frequent target of this illness, our objective was to determine the neuroprotective effect of IP consumption in LAC-bearing mice. They were orally treated with 50 mg of IP extract/kg/day (IP50) for 3 weeks...
January 19, 2019: Nutrition and Cancer
https://read.qxmd.com/read/30637710/the-role-of-immunotherapy-in-small-cell-lung-cancer
#13
REVIEW
A Calles, G Aguado, C Sandoval, R Álvarez
Despite decades of research, prognosis for SCLC patients remains poor, and treatment options limited. SCLC is an immunogenic tumor with high somatic mutation rates due to tobacco exposure resulting in potential neo-antigens, the presence of suppressed immune responses, and occurrence of paraneoplastic disorders. The use of T cell immune-checkpoint inhibitors (anti-PD1: nivolumab, pembrolizumab; anti-PD-L1: atezolizumab, durvalumab; anti-CTLA-4: ipilimumab, tremelimumab) have shown promising antitumor activity with the potential to prolong survival in SCLC patients...
January 12, 2019: Clinical & Translational Oncology
https://read.qxmd.com/read/30627102/lambert-eaton-myasthenic-syndrome-caused-by-nivolumab-in-a-patient-with-squamous-cell-lung-cancer
#14
Yuki Nakatani, Natsuki Tanaka, Tomomi Enami, Seigo Minami, Tomoko Okazaki, Kiyoshi Komuta
Lambert-Eaton myasthenic syndrome (LEMS) is a representative paraneoplastic neurological syndrome. Recently, nivolumab, an anti-programmed cell death 1 inhibitor, has been approved for advanced non-small-cell lung cancer. Careful attention should be paid to immune-related adverse events (irAEs), including neurotoxicity. We herein report a 73-year-old woman with LEMS that occurred during nivolumab treatment for pulmonary squamous cell carcinoma. After the 20th week of nivolumab, she experienced various neurological symptoms such as ptosis, lower limb weakness, and photophobia...
September 2018: Case Reports in Neurology
https://read.qxmd.com/read/30626830/successful-treatment-of-ros1-rearranged-lung-cancer-complicated-by-hypertrophic-pulmonary-osteoarthropathy-with-crizotinib-therapy-a-case-report
#15
Naoko Katsurada, Motoko Tachihara, Naoe Jimbo, Kiyoko Koyama, Kyosuke Nakata, Tatsuya Nagano, Masatsugu Yamamoto, Hiroshi Kamiryo, Kazuyuki Kobayashi, Yoshihiro Nishimura
Hypertrophic pulmonary osteoarthropathy (HPO) is a paraneoplastic syndrome characterized by digital clubbing, arthritis, and periostitis. Tumor removal usually leads to the resolution of these symptoms. We herein report the efficacy of crizotinib treatment for treating the symptoms of HPO associated with c-ros oncogene 1 receptor tyrosine kinase (ROS1)-rearranged lung cancer. A 71-year-old woman presented with a pulmonary tumor and arthritis. She was diagnosed with a ROS1-rearranged lung adenocarcinoma (stage IIIB [cT4N2M0]) with HPO...
January 10, 2019: Internal Medicine
https://read.qxmd.com/read/30622890/paraneoplastic-limbic-encephalitis-revealing-a-small-cell-carcinoma-of-the-lung
#16
Marwa Kacem, Nidhal Belloumi, Imene Bachouche, Mariem Mersni, Fatma Chermiti Ben Abdallah, Soraya Fenniche
Introduction: Paraneoplastic limbic encephalitis is a rare disease, usually associated with small cell lung cancer. Case report: We report in this publication the cases with different age brackets, who presented with various neurological symptoms such as repetitive seizures or anterograde amnesia. Cerebral CT-scan, cerebral MRI and anti onco-neural paraneoplastic antibodies were suggesting the diagnosis of paraneoplastic limbic encephalitis. Etiological exploration lead to the diagnosis of locally advanced small cell carcinoma of the lung...
2019: Respiratory Medicine Case Reports
https://read.qxmd.com/read/30620044/a-systematic-review-of-gamma-aminobutyric-acid-receptor-type-b-autoimmunity
#17
Jake H McKay, Elliot L Dimberg, Alfonso S Lopez Chiriboga
OBJECTIVE: To review the available research to describe the clinical characteristics and neoplastic associations of patients with gamma-aminobutyric acid receptor type B (GABAB-R) autoantibodies. METHODS: Literature was reviewed on PubMed, Mendeley literature search, and the American Academy of Neurology database for articles published from June 2008 to October of 2018 using a variety of key words. These key words include: "gamma-aminobutyric acid seizures," "gamma-aminobutyric acid limbic encephalitis", "GABA(B) receptor antibodies," "autoimmune encephalitis," "autoimmune epilepsy," "GABA(B) encephalitis, " and "GABA paraneoplastic...
January 8, 2019: Neurologia i Neurochirurgia Polska
https://read.qxmd.com/read/30603606/galactorrhea-mastodynia-and-gynecomastia-as-the-first-manifestation-of-lung-adenocarcinoma-a-case-report
#18
A Lazopoulos, D Krimiotis, N C Schizas, T Rallis, A S Gogakos, F Chatzinikolaou, T Tsiouda, P Zarogoulidis, P Sarafis, P Kamparoudi, D Paliouras, N Barbetakis
Gynecomastia with mastodynia and galactorrhea as a paraneoplastic syndrome due to lung cancer with complete response after surgical excision is rare. A 62-year-old Caucasian male presented with mastodynia, galactorrhea and right breast enlargement. Chest x-ray revealed a left upper lobe tumor. The patient had high levels of serum beta-human chorionic gonadotropin (b-HCG) and prolactine. Complete staging was negative for metastases. A typical left upper lobectomy with radical mediastinal lymph node dissection was performed...
2019: Respiratory Medicine Case Reports
https://read.qxmd.com/read/30602160/pseudoachalasia-as-first-manifestation-of-a-malignancy
#19
Elisabeth Fabian, Andreas J Eherer, Carolin Lackner, Christian Urban, Freyja-Maria Smolle-Juettner, Guenter J Krejs
Pseudoachalasia is a condition in which symptoms, radiologic, endoscopic, and manometric findings mimick idiopathic achalasia. About 4% of patients with a typical constellation for idiopathic achalasia will turn out to have pseudoachalasia, posing a major diagnostic challenge. A large spectrum of underlying causes of pseudoachalasia has been described. However, in about 70% of affected patients, this condition is caused by a malignancy (mostly adenocarcinoma of the esophagogastric junction or cardia). We describe a 16-year-old high school student referred for management of achalasia who turned out to have pseudoachalasia due to adenocarcinoma of the cardia...
January 2, 2019: Digestive Diseases
https://read.qxmd.com/read/30588355/paraneoplastic-encephalopathy-in-a-patient-with-metastatic-lung-cancer-a-case-study
#20
REVIEW
Scott M Rowley
CASE STUDY RS, a 36-year-old female, presented to the emergency department (ED) of a large academic medical center upon the advice of her primary care provider because of 3 weeks of progressive mental status changes, weakness, and decreased oral intake. According to her husband, RS was diagnosed with stage IIIA large cell lung cancer 8 months earlier and was treated with concurrent chemotherapy (carboplatin, pemetrexed, and bevacizumab) and radiation therapy that was completed 4 months prior to admission. No other specific information about her treatment or outside health records was available...
March 2018: Journal of the Advanced Practitioner in Oncology
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