Sudarshan Paramsothy, Shaun Nielsen, Michael A Kamm, Nandan P Deshpande, Jeremiah J Faith, Jose C Clemente, Ramesh Paramsothy, Alissa J Walsh, Johan van den Bogaerde, Douglas Samuel, Rupert W L Leong, Susan Connor, Watson Ng, Enmoore Lin, Thomas J Borody, Marc R Wilkins, Jean-Frederic Colombel, Hazel M Mitchell, Nadeem O Kaakoush
BACKGROUND & AIMS: Fecal microbiota transplantation (FMT) can induce remission in patients with ulcerative colitis (UC). In a randomized controlled trial of FMT in patients with active UC, we aimed to identify bacterial taxonomic and functional factors associated with response to therapy. METHODS: We performed a double-blind trial of 81 patients with active UC randomly assigned to groups that received an initial colonoscopic infusion and then intensive multidonor FMT or placebo enemas, 5 d/wk for 8 weeks...
April 2019: Gastroenterology