keyword
https://read.qxmd.com/read/38668619/sortase-modified-cholera-toxoids-show-specific-golgi-localization
#1
JOURNAL ARTICLE
Darren C Machin, Daniel J Williamson, Peter Fisher, Victoria J Miller, Zoe L P Arnott, Charlotte M E Stevenson, Gemma C Wildsmith, James F Ross, Christopher W Wasson, Andrew Macdonald, Benjamin I Andrews, Daniel Ungar, W Bruce Turnbull, Michael E Webb
Cholera toxoid is an established tool for use in cellular tracing in neuroscience and cell biology. We use a sortase labeling approach to generate site-specific N-terminally modified variants of both the A2-B5 heterohexamer and B5 pentamer forms of the toxoid. Both forms of the toxoid are endocytosed by GM1-positive mammalian cells, and while the heterohexameric toxoid was principally localized in the ER, the B5 pentamer showed an unexpectedly specific localization in the medial/trans-Golgi. This study suggests a future role for specifically labeled cholera toxoids in live-cell imaging beyond their current applications in neuronal tracing and labeling of lipid rafts in fixed cells...
April 16, 2024: Toxins
https://read.qxmd.com/read/38665213/use-of-quantitative-in-vitro-to-in-vivo-extrapolation-qivive-for-the-assessment-of-non-combustible-next-generation-product-aerosols
#2
JOURNAL ARTICLE
Marjory Moreau, Liam Simms, Melvin E Andersen, Edgar Trelles Sticken, Roman Wieczorek, Sarah Jean Pour, Fiona Chapman, Karin Roewer, Sandra Otte, Jeffrey Fisher, Matthew Stevenson
With the use of in vitro new approach methodologies (NAMs) for the assessment of non-combustible next-generation nicotine delivery products, new extrapolation methods will also be required to interpret and contextualize the physiological relevance of these results. Quantitative in vitro to in vivo extrapolation (QIVIVE) can translate in vitro concentrations into in-life exposures with physiologically-based pharmacokinetic (PBPK) modelling and provide estimates of the likelihood of harmful effects from expected exposures...
2024: Frontiers in toxicology
https://read.qxmd.com/read/38649085/a-randomized-clinical-trial-of-catheter-ablation-and-antiarrhythmic-drug-therapy-for-suppression-of-ventricular-tachycardia-in-ischemic-cardiomyopathy-the-vanish2-trial
#3
JOURNAL ARTICLE
John L Sapp, Anthony S L Tang, Ratika Parkash, William G Stevenson, Jeff S Healey, George Wells
Recurrent ventricular tachycardia (VT) in patients with prior myocardial infarction is associated with adverse quality of life and clinical outcomes, despite the presence of implanted defibrillators (ICDs). Suppression of recurrent VT can be accomplished with antiarrhythmic drug therapy or catheter ablation. The Ventricular Tachycardia Antiarrhythmics or Ablation In Structural Heart Disease 2 (VANISH2) trial is designed to determine whether ablation is superior to antiarrhythmic drug therapy as first line therapy for patients with ischemic cardiomyopathy and VT...
April 20, 2024: American Heart Journal
https://read.qxmd.com/read/38647300/the-bond-energy-of-un-guided-ion-beam-studies-of-the-reactions-of-u-with-n2-and-no
#4
JOURNAL ARTICLE
Amanda R Bubas, Arjun Kafle, Brandon C Stevenson, P B Armentrout
A guided ion beam tandem mass spectrometer was used to study the reactions of U+ with N2 and NO. Reaction cross sections were measured over a wide range of energy for both systems. In each reaction, UN+ is formed by an endothermic process, thereby enabling the direct measurement of the threshold energy and determination of the UN+ bond dissociation energy. For the reaction of U+ + N2, a threshold energy (E0) of 4.02 ± 0.11 eV was measured, leading to D0 (UN+) = 5.73 ± 0.11 eV. The reaction of U+ + NO yields UO+ through an exothermic, barrierless process that proceeds with 94 ± 23% efficiency at the lowest energy...
April 28, 2024: Journal of Chemical Physics
https://read.qxmd.com/read/38645303/the-effectiveness-of-abstinence-based-and-harm-reduction-based-interventions-in-reducing-problematic-substance-use-in-adults-who-are-experiencing-homelessness-in-high-income-countries-a-systematic-review-and-meta-analysis-a-systematic-review
#5
REVIEW
Chris O'Leary, Rob Ralphs, Jennifer Stevenson, Andrew Smith, Jordan Harrison, Zsolt Kiss, Harry Armitage
BACKGROUND: Homelessness is a traumatic experience, and can have a devastating effect on those experiencing it. People who are homeless often face significant barriers when accessing public services, and have often experienced adverse childhood events, extreme social disadvantage, physical, emotional and sexual abuse, neglect, low self-esteem, poor physical and mental health, and much lower life expectancy compared to the general population. Rates of problematic substance use are disproportionately high, with many using drugs and alcohol to deal with the stress of living on the street, to keep warm, or to block out memories of previous abuse or trauma...
June 2024: Campbell Syst Rev
https://read.qxmd.com/read/38645088/multi-scale-in-vivo-imaging-of-tumour-development-using-a-germline-conditional-triple-reporter-system
#6
Piotr Dzien, Ximena Raffo Iraolagoitia, Stephanie May, David Stevenson, Lynn McGarry, Dmitry Soloviev, Gavin Brown, Colin Nixon, Chrysa Kapeni, Maike De La Roche, Karen Blyth, Scott Lyons, Thomas Bird, Douglas Strathdee, Gilbert Fruhwirth, Leo Carlin, David Lewis
Imaging reporter genes are indispensable for visualising biological processes in living subjects, particularly in cancer research where they have been used to observe tumour development, cancer cell dissemination, and treatment response. Engineering reporter genes into the germline frequently involves single imaging modality reporters operating over limited spatial scales. To address these limitations, we developed an inducible triple-reporter mouse model (Rosa26 LSL - NRL ) that integrates reporters for complementary imaging modalities, fluorescence, bioluminescence and positron emission tomography (PET), along with inducible Cre-lox functionality for precise spatiotemporal control of reporter expression...
April 3, 2024: Research Square
https://read.qxmd.com/read/38641149/beyond-prevention-unveiling-the-benefits-of-triple-vaccination-on-covid-19-severity-and-resource-utilization-in-solid-organ-transplant-recipients
#7
JOURNAL ARTICLE
Jared R Zhang, John C Johnson, Richard G Preble, Muhammad Mujtaba, A Scott Lea, Heather L Stevenson, Michael Kueht
OBJECTIVE: Despite the widespread reduction in COVID-19-related morbidity and mortality attributed to vaccination in the general population, vaccine efficacy in solid organ transplant recipients (SOTR) remains under-characterized. This study aimed to investigate clinically relevant outcomes on double and triple-vaccinated versus unvaccinated SOTR with COVID-19. STUDY DESIGN AND SETTING: A retrospective propensity score-matched cohort study was performed utilizing data from the US Collaborative Network Database within TriNetX (n = 117,905,631)...
April 17, 2024: Transplant Immunology
https://read.qxmd.com/read/38639698/impact-of-insurance-status-and-region-on-angiotensin-receptor-neprilysin-inhibitor-prescription-during-heart%C3%A2-failure-hospitalizations
#8
JOURNAL ARTICLE
Giovanni Davogustto, Quinn S Wells, Frank E Harrell, Stephen J Greene, Dan M Roden, Lynne W Stevenson
BACKGROUND: An angiotensin receptor-neprilysin inhibitor (ARNI) is the preferred renin-angiotensin system (RAS) inhibitor for heart failure with reduced ejection fraction (HFrEF). Among eligible patients, insurance status and prescriber concern regarding out-of-pocket costs may constrain early initiation of ARNI and other new therapies. OBJECTIVES: In this study, the authors sought to evaluate the association of insurance and other social determinants of health with ARNI initiation at discharge from HFrEF hospitalization...
April 4, 2024: JACC. Heart Failure
https://read.qxmd.com/read/38639469/treatment-patterns-of-patients-with-worsening-heart-failure-with-reduced-ejection-fraction
#9
JOURNAL ARTICLE
Stephen J Greene, Hanna K Gaggin, Mo Zhou, Lori D Bash, Dominik Lautsch, Laurence Djatche, Yan Song, James Signorovitch, Andra S Stevenson, Robert O Blaustein, Javed Butler
AIMS: Patients with HFrEF and worsening HF events (WHFE) are at particularly high risk and urgently need disease-modifying therapy. CHART-HF assessed treatment patterns and reasons for medication decisions among HFrEF patients with and without WHFE. METHODS AND RESULTS: CHART-HF collected retrospective electronic medical records of outpatients with HF and EF < 45% between 2017-2019 from a nationwide panel of 238 cardiologists (458 patients) and the Geisinger Health System (GHS) medical record (1000 patients)...
April 19, 2024: ESC Heart Failure
https://read.qxmd.com/read/38637152/activity-dependent-ectopic-spiking-in-parvalbumin-expressing-interneurons-of-the-neocortex
#10
JOURNAL ARTICLE
Brian B Theyel, Rachel J Stevenson, Barry W Connors
Canonically, action potentials of most mammalian neurons initiate at the axon initial segment and propagate bidirectionally: orthodromically along the distal axon, and retrogradely into the soma and dendrites. Under some circumstances action potentials may initiate ectopically, at sites distal to the axon initial segment, and propagate antidromically along the axon. These 'ectopic action potentials' (EAPs) have been observed in experimental models of seizures and chronic pain, and more rarely in nonpathological forebrain neurons...
April 18, 2024: ENeuro
https://read.qxmd.com/read/38633130/chronic-myeloproliferative-neoplasm-in-adulthood-in-cbl-syndrome-harboring-a-splice-site-cbl-variant-alongside-a-novel-constitutional-csf3r-variant
#11
George Mason, Rhian Aghajani, Brieanna Dance, Jad Othman, Linda Goodwin, William Stevenson, Naomi Mackinlay
Casitas B-cell lineage (CBL) syndrome is a rare RASopathy known to predispose to CBL-mutated juvenile myelomonocytic leukemia (JMML) in childhood. Adulthood acute myeloid leukemia arising out of a genetic aberrancies consistent with prior CBL-mutated JMML has been twice previously described, but chronic myeloproliferative neoplasia has not. We present a case of progressive myeloproliferative neoplasm in adulthood in the context of CBL syndrome alongside a novel CSF3R variant. We also review pathogenic splice-site mutations in CBL-mutated JMML...
April 2024: EJHaem
https://read.qxmd.com/read/38629804/judicial-actors-understanding-of-the-mental-health-impacts-of-intimate-partner-violence-a-scoping-review
#12
REVIEW
Susan Lynn Heward-Belle, Parveen Azam Ali, Julieta Marotta, Debbie Hager, Michaela Rogers, Lynette Stevenson
Intimate partner violence (IPV) is a global public health issue that has grave physical and mental health consequences for millions of women. The judicial system plays a critical role in responding to IPV principally through the criminal justice system, family law, and/or child welfare jurisdictions. However, victims/survivors who interact with the legal system report negative experiences. An under-researched area of scholarship is the degree to which judicial actors understand the mental health impacts of IPV on victims/survivors and how they apply that knowledge in practice...
April 17, 2024: Trauma, Violence & Abuse
https://read.qxmd.com/read/38623837/a-qualitative-exploration-of-the-barriers-and-facilitators-to-self-managing-multiple-long-term-conditions-amongst-people-experiencing-socioeconomic-deprivation
#13
JOURNAL ARTICLE
Abi Woodward, Danielle Nimmons, Nathan Davies, Kate Walters, Fiona A Stevenson, Joanne Protheroe, Carolyn A Chew-Graham, Megan Armstrong
BACKGROUND: Globally, it is estimated that one in three adults live with two or more long-term conditions (multiple long-term conditions, MLTCs), that require self-management. People who experience socioeconomic deprivation face significant health inequalities due to a range of interrelated characteristics that lead to a lack of resources and opportunities. Previous research with underserved populations indicate low levels of trust towards primary care providers and potential barriers for developing patient-healthcare professional relationships...
April 2024: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://read.qxmd.com/read/38622772/a-narrative-synthesis-of-the-effectiveness-and-acceptability-of-musculoskeletal-first-contact-physiotherapy-practitioner-roles-in-primary-care
#14
JOURNAL ARTICLE
Greg Bicker, Tina Hadley-Barrows, Andrew Saunders, Hilary Mairs, Kay Stevenson
BACKGROUND: Musculoskeletal (MSK) First Contact Practitioners (FCP), diagnostic clinicians with expertise in the assessment and management of undifferentiated MSK conditions in primary care have been widely employed in the United Kingdom since 2020. The role aims to bring specialist clinical knowledge to patients at the first point of contact and reduce the burden on existing primary care services. Since the national adoption of the role, little has been published to support the effectiveness or acceptability of the role...
June 2024: Musculoskeletal Care
https://read.qxmd.com/read/38621478/rasopathies-influences-on-neuroanatomical-variation-in-children
#15
JOURNAL ARTICLE
Chloe Alexa McGhee, Hamed Honari, Monica Siqueiros-Sanchez, Yaffa Serur, Eric K van Staalduinen, David Stevenson, Jennifer L Bruno, Mira Michelle Raman, Tamar Green
BACKGROUND: RASopathies are a group of disorders characterized by pathogenic mutations in the Ras-mitogen-activated protein kinase (Ras/MAPK) signaling pathway. Distinct pathogenic variants in genes encoding proteins in the Ras/MAPK pathway cause Noonan syndrome (NS) and neurofibromatosis type 1 (NF1), which are associated with increased risk for autism spectrum disorder (ASD) and attention deficit and hyperactivity disorder (ADHD). METHODS: This study examines the effect RASopathies (NS and NF1) has on human neuroanatomy, specifically on surface area (SA), cortical thickness (CT), and subcortical volumes...
April 13, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://read.qxmd.com/read/38621019/co-designing-a-health-journey-mapping-resource-for-culturally-safe-health-care-with-and-for-first-nations-people
#16
JOURNAL ARTICLE
Alyssa Cormick, Amy Graham, Tahlee Stevenson, Kelli Owen, Kim O'Donnell, Janet Kelly
Background Many healthcare professionals and services strive to improve cultural safety of care for Australia's First Nations people. However, they work within established systems and structures that do not reliably meet diverse health care needs nor reflect culturally safe paradigms. Journey mapping approaches can improve understanding of patient/client healthcare priorities and care delivery challenges from healthcare professionals' perspectives leading to improved responses that address discriminatory practices and institutional racism...
April 2024: Australian Journal of Primary Health
https://read.qxmd.com/read/38619368/gamma-ray-dose-threshold-for-mapbi-3-solar-cells
#17
JOURNAL ARTICLE
A G Boldyreva, A V Novikov, V G Petrov, A N Zhivchikova, M M Tepliakova, K J Stevenson
In this work, we report on the effects observed in MAPbI3 polycrystalline films and solar cells under moderate gamma-ray doses of 3-21 kGy. We applied several instrumental techniques such as photoluminescence spectroscopy, time-resolved photoluminescence, Suns- V OC measurement, and impedance spectroscopy to characterize exposed samples. We observed a nonlinear dependency of such characteristics as PL intensity, career lifetime, ideality factor, and recombination resistance on the exposure dose. Small doses of 3-5 kGy annihilate some of the defect centers in the material, which results in improved carrier extraction and prolonged carrier lifetime, while with larger doses of 10 kGy and above, nonradiative recombination becomes predominant...
April 15, 2024: Physical Chemistry Chemical Physics: PCCP
https://read.qxmd.com/read/38613283/study-of-high-transverse-momentum-higgs-boson-production-in-association-with-a-vector-boson-in-the-qqbb-final-state-with-the-atlas-detector
#18
JOURNAL ARTICLE
G Aad, B Abbott, K Abeling, N J Abicht, S H Abidi, A Aboulhorma, H Abramowicz, H Abreu, Y Abulaiti, B S Acharya, C Adam Bourdarios, L Adamczyk, S V Addepalli, M J Addison, J Adelman, A Adiguzel, T Adye, A A Affolder, Y Afik, M N Agaras, J Agarwala, A Aggarwal, C Agheorghiesei, A Ahmad, F Ahmadov, W S Ahmed, S Ahuja, X Ai, G Aielli, A Aikot, M Ait Tamlihat, B Aitbenchikh, I Aizenberg, M Akbiyik, T P A Åkesson, A V Akimov, D Akiyama, N N Akolkar, S Aktas, K Al Khoury, G L Alberghi, J Albert, P Albicocco, G L Albouy, S Alderweireldt, Z L Alegria, M Aleksa, I N Aleksandrov, C Alexa, T Alexopoulos, F Alfonsi, M Algren, M Alhroob, B Ali, H M J Ali, S Ali, S W Alibocus, M Aliev, G Alimonti, W Alkakhi, C Allaire, B M M Allbrooke, J F Allen, C A Allendes Flores, P P Allport, A Aloisio, F Alonso, C Alpigiani, M Alvarez Estevez, A Alvarez Fernandez, M Alves Cardoso, M G Alviggi, M Aly, Y Amaral Coutinho, A Ambler, C Amelung, M Amerl, C G Ames, D Amidei, S P Amor Dos Santos, K R Amos, V Ananiev, C Anastopoulos, T Andeen, J K Anders, S Y Andrean, A Andreazza, S Angelidakis, A Angerami, A V Anisenkov, A Annovi, C Antel, M T Anthony, E Antipov, M Antonelli, F Anulli, M Aoki, T Aoki, J A Aparisi Pozo, M A Aparo, L Aperio Bella, C Appelt, A Apyan, N Aranzabal, S J Arbiol Val, C Arcangeletti, A T H Arce, E Arena, J-F Arguin, S Argyropoulos, J-H Arling, O Arnaez, H Arnold, G Artoni, H Asada, K Asai, S Asai, N A Asbah, K Assamagan, R Astalos, S Atashi, R J Atkin, M Atkinson, H Atmani, P A Atmasiddha, K Augsten, S Auricchio, A D Auriol, V A Austrup, G Avolio, K Axiotis, G Azuelos, D Babal, H Bachacou, K Bachas, A Bachiu, F Backman, A Badea, T M Baer, P Bagnaia, M Bahmani, D Bahner, A J Bailey, V R Bailey, J T Baines, L Baines, O K Baker, E Bakos, D Bakshi Gupta, V Balakrishnan, R Balasubramanian, E M Baldin, P Balek, E Ballabene, F Balli, L M Baltes, W K Balunas, J Balz, E Banas, M Bandieramonte, A Bandyopadhyay, S Bansal, L Barak, M Barakat, E L Barberio, D Barberis, M Barbero, M Z Barel, K N Barends, T Barillari, M-S Barisits, T Barklow, P Baron, D A Baron Moreno, A Baroncelli, G Barone, A J Barr, J D Barr, L Barranco Navarro, F Barreiro, J Barreiro Guimarães da Costa, U Barron, M G Barros Teixeira, S Barsov, F Bartels, R Bartoldus, A E Barton, P Bartos, A Basan, M Baselga, A Bassalat, M J Basso, C R Basson, R L Bates, S Batlamous, J R Batley, B Batool, M Battaglia, D Battulga, M Bauce, M Bauer, P Bauer, L T Bazzano Hurrell, J B Beacham, T Beau, J Y Beaucamp, P H Beauchemin, P Bechtle, H P Beck, K Becker, A J Beddall, V A Bednyakov, C P Bee, L J Beemster, T A Beermann, M Begalli, M Begel, A Behera, J K Behr, J F Beirer, F Beisiegel, M Belfkir, G Bella, L Bellagamba, A Bellerive, P Bellos, K Beloborodov, D Benchekroun, F Bendebba, Y Benhammou, M Benoit, S Bentvelsen, L Beresford, M Beretta, E Bergeaas Kuutmann, N Berger, B Bergmann, J Beringer, G Bernardi, C Bernius, F U Bernlochner, F Bernon, A Berrocal Guardia, T Berry, P Berta, A Berthold, I A Bertram, S Bethke, A Betti, A J Bevan, N K Bhalla, M Bhamjee, S Bhatta, D S Bhattacharya, P Bhattarai, V S Bhopatkar, R Bi, R M Bianchi, G Bianco, O Biebel, R Bielski, M Biglietti, M Bindi, A Bingul, C Bini, A Biondini, C J Birch-Sykes, G A Bird, M Birman, M Biros, S Biryukov, T Bisanz, E Bisceglie, J P Biswal, D Biswas, A Bitadze, K Bjørke, I Bloch, A Blue, U Blumenschein, J Blumenthal, G J Bobbink, V S Bobrovnikov, M Boehler, B Boehm, D Bogavac, A G Bogdanchikov, C Bohm, V Boisvert, P Bokan, T Bold, M Bomben, M Bona, M Boonekamp, C D Booth, A G Borbély, I S Bordulev, H M Borecka-Bielska, G Borissov, D Bortoletto, D Boscherini, M Bosman, J D Bossio Sola, K Bouaouda, N Bouchhar, J Boudreau, E V Bouhova-Thacker, D Boumediene, R Bouquet, A Boveia, J Boyd, D Boye, I R Boyko, J Bracinik, N Brahimi, G Brandt, O Brandt, F Braren, B Brau, J E Brau, R Brener, L Brenner, R Brenner, S Bressler, D Britton, D Britzger, I Brock, G Brooijmans, W K Brooks, E Brost, L M Brown, L E Bruce, T L Bruckler, P A Bruckman de Renstrom, B Brüers, A Bruni, G Bruni, M Bruschi, N Bruscino, T Buanes, Q Buat, D Buchin, A G Buckley, O Bulekov, B A Bullard, S Burdin, C D Burgard, A M Burger, B Burghgrave, O Burlayenko, J T P Burr, C D Burton, J C Burzynski, E L Busch, V Büscher, P J Bussey, J M Butler, C M Buttar, J M Butterworth, W Buttinger, C J Buxo Vazquez, A R Buzykaev, S Cabrera Urbán, L Cadamuro, D Caforio, H Cai, Y Cai, Y Cai, V M M Cairo, O Cakir, N Calace, P Calafiura, G Calderini, P Calfayan, G Callea, L P Caloba, D Calvet, S Calvet, M Calvetti, R Camacho Toro, S Camarda, D Camarero Munoz, P Camarri, M T Camerlingo, D Cameron, C Camincher, M Campanelli, A Camplani, V Canale, A Canesse, J Cantero, Y Cao, F Capocasa, M Capua, A Carbone, R Cardarelli, J C J Cardenas, F Cardillo, G Carducci, T Carli, G Carlino, J I Carlotto, B T Carlson, E M Carlson, L Carminati, A Carnelli, M Carnesale, S Caron, E Carquin, S Carrá, G Carratta, F Carrio Argos, J W S Carter, T M Carter, M P Casado, M Caspar, F L Castillo, L Castillo Garcia, V Castillo Gimenez, N F Castro, A Catinaccio, J R Catmore, V Cavaliere, N Cavalli, V Cavasinni, Y C Cekmecelioglu, E Celebi, F Celli, M S Centonze, V Cepaitis, K Cerny, A S Cerqueira, A Cerri, L Cerrito, F Cerutti, B Cervato, A Cervelli, G Cesarini, S A Cetin, D Chakraborty, J Chan, W Y Chan, J D Chapman, E Chapon, B Chargeishvili, D G Charlton, M Chatterjee, C Chauhan, S Chekanov, S V Chekulaev, G A Chelkov, A Chen, B Chen, B Chen, H Chen, H Chen, J Chen, J Chen, M Chen, S Chen, S J Chen, X Chen, X Chen, Y Chen, C L Cheng, H C Cheng, S Cheong, A Cheplakov, E Cheremushkina, E Cherepanova, R Cherkaoui El Moursli, E Cheu, K Cheung, L Chevalier, V Chiarella, G Chiarelli, N Chiedde, G Chiodini, A S Chisholm, A Chitan, M Chitishvili, M V Chizhov, K Choi, A R Chomont, Y Chou, E Y S Chow, T Chowdhury, K L Chu, M C Chu, X Chu, J Chudoba, J J Chwastowski, D Cieri, K M Ciesla, V Cindro, A Ciocio, F Cirotto, Z H Citron, M Citterio, D A Ciubotaru, A Clark, P J Clark, C Clarry, J M Clavijo Columbie, S E Clawson, C Clement, J Clercx, Y Coadou, M Cobal, A Coccaro, R F Coelho Barrue, R Coelho Lopes De Sa, S Coelli, A E C Coimbra, B Cole, J Collot, P Conde Muiño, M P Connell, S H Connell, I A Connelly, E I Conroy, F Conventi, H G Cooke, A M Cooper-Sarkar, A Cordeiro Oudot Choi, L D Corpe, M Corradi, F Corriveau, A Cortes-Gonzalez, M J Costa, F Costanza, D Costanzo, B M Cote, G Cowan, K Cranmer, D Cremonini, S Crépé-Renaudin, F Crescioli, M Cristinziani, M Cristoforetti, V Croft, J E Crosby, G Crosetti, A Cueto, T Cuhadar Donszelmann, H Cui, Z Cui, W R Cunningham, F Curcio, P Czodrowski, M M Czurylo, M J Da Cunha Sargedas De Sousa, J V Da Fonseca Pinto, C Da Via, W Dabrowski, T Dado, S Dahbi, T Dai, D Dal Santo, C Dallapiccola, M Dam, G D'amen, V D'Amico, J Damp, J R Dandoy, M Danninger, V Dao, G Darbo, S Darmora, S J Das, S D'Auria, C David, T Davidek, B Davis-Purcell, I Dawson, H A Day-Hall, K De, R De Asmundis, N De Biase, S De Castro, N De Groot, P de Jong, H De la Torre, A De Maria, A De Salvo, U De Sanctis, F De Santis, A De Santo, J B De Vivie De Regie, D V Dedovich, J Degens, A M Deiana, F Del Corso, J Del Peso, F Del Rio, L Delagrange, F Deliot, C M Delitzsch, M Della Pietra, D Della Volpe, A Dell'Acqua, L Dell'Asta, M Delmastro, P A Delsart, S Demers, M Demichev, S P Denisov, L D'Eramo, D Derendarz, F Derue, P Dervan, K Desch, C Deutsch, F A Di Bello, A Di Ciaccio, L Di Ciaccio, A Di Domenico, C Di Donato, A Di Girolamo, G Di Gregorio, A Di Luca, B Di Micco, R Di Nardo, C Diaconu, M Diamantopoulou, F A Dias, T Dias Do Vale, M A Diaz, F G Diaz Capriles, M Didenko, E B Diehl, L Diehl, S Díez Cornell, C Diez Pardos, C Dimitriadi, A Dimitrievska, J Dingfelder, I-M Dinu, S J Dittmeier, F Dittus, F Djama, T Djobava, C Doglioni, A Dohnalova, J Dolejsi, Z Dolezal, K M Dona, M Donadelli, B Dong, J Donini, A D'Onofrio, M D'Onofrio, J Dopke, A Doria, N Dos Santos Fernandes, P Dougan, M T Dova, A T Doyle, M A Draguet, E Dreyer, I Drivas-Koulouris, M Drnevich, A S Drobac, M Drozdova, D Du, T A du Pree, F Dubinin, M Dubovsky, E Duchovni, G Duckeck, O A Ducu, D Duda, A Dudarev, E R Duden, M D'uffizi, L Duflot, M Dührssen, A E Dumitriu, M Dunford, S Dungs, K Dunne, A Duperrin, H Duran Yildiz, M Düren, A Durglishvili, B L Dwyer, G I Dyckes, M Dyndal, B S Dziedzic, Z O Earnshaw, G H Eberwein, B Eckerova, S Eggebrecht, E Egidio Purcino De Souza, L F Ehrke, G Eigen, K Einsweiler, T Ekelof, P A Ekman, S El Farkh, Y El Ghazali, H El Jarrari, A El Moussaouy, V Ellajosyula, M Ellert, F Ellinghaus, N Ellis, J Elmsheuser, M Elsing, D Emeliyanov, Y Enari, I Ene, S Epari, P A Erland, M Errenst, M Escalier, C Escobar, E Etzion, G Evans, H Evans, L S Evans, M O Evans, A Ezhilov, S Ezzarqtouni, F Fabbri, L Fabbri, G Facini, V Fadeyev, R M Fakhrutdinov, D Fakoudis, S Falciano, L F Falda Ulhoa Coelho, P J Falke, J Faltova, C Fan, Y Fan, Y Fang, M Fanti, M Faraj, Z Farazpay, A Farbin, A Farilla, T Farooque, S M Farrington, F Fassi, 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Schumacher, B A Schumm, Ph Schune, A J Schuy, H R Schwartz, A Schwartzman, T A Schwarz, Ph Schwemling, R Schwienhorst, A Sciandra, G Sciolla, F Scuri, C D Sebastiani, K Sedlaczek, P Seema, S C Seidel, A Seiden, B D Seidlitz, C Seitz, J M Seixas, G Sekhniaidze, L Selem, N Semprini-Cesari, D Sengupta, V Senthilkumar, L Serin, L Serkin, M Sessa, H Severini, F Sforza, A Sfyrla, E Shabalina, R Shaheen, J D Shahinian, D Shaked Renous, L Y Shan, M Shapiro, A Sharma, A S Sharma, P Sharma, S Sharma, P B Shatalov, K Shaw, S M Shaw, A Shcherbakova, Q Shen, D J Sheppard, P Sherwood, L Shi, X Shi, C O Shimmin, J D Shinner, I P J Shipsey, S Shirabe, M Shiyakova, J Shlomi, M J Shochet, J Shojaii, D R Shope, B Shrestha, S Shrestha, E M Shrif, M J Shroff, P Sicho, A M Sickles, E Sideras Haddad, A Sidoti, F Siegert, Dj Sijacki, F Sili, J M Silva, M V Silva Oliveira, S B Silverstein, S Simion, R Simoniello, E L Simpson, H Simpson, L R Simpson, N D Simpson, S Simsek, S Sindhu, P Sinervo, S Singh, S Sinha, S Sinha, M Sioli, I Siral, E Sitnikova, S Yu Sivoklokov, J Sjölin, A Skaf, E Skorda, P Skubic, M Slawinska, V Smakhtin, B H Smart, S Yu Smirnov, Y Smirnov, L N Smirnova, O Smirnova, A C Smith, E A Smith, H A Smith, J L Smith, R Smith, M Smizanska, K Smolek, A A Snesarev, S R Snider, H L Snoek, S Snyder, R Sobie, A Soffer, C A Solans Sanchez, E Yu Soldatov, U Soldevila, A A Solodkov, S Solomon, A Soloshenko, K Solovieva, O V Solovyanov, V Solovyev, P Sommer, A Sonay, W Y Song, A Sopczak, A L Sopio, F Sopkova, J D Sorenson, I R Sotarriva Alvarez, V Sothilingam, O J Soto Sandoval, S Sottocornola, R Soualah, Z Soumaimi, D South, N Soybelman, S Spagnolo, M Spalla, D Sperlich, G Spigo, S Spinali, D P Spiteri, M Spousta, E J Staats, A Stabile, R Stamen, A Stampekis, M Standke, E Stanecka, M V Stange, B Stanislaus, M M Stanitzki, B Stapf, E A Starchenko, G H Stark, J Stark, P Staroba, P Starovoitov, S Stärz, R Staszewski, G Stavropoulos, J Steentoft, P Steinberg, B Stelzer, H J Stelzer, O 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Zamora Saa, J Zang, D Zanzi, O Zaplatilek, C Zeitnitz, H Zeng, J C Zeng, D T Zenger, O Zenin, T Ženiš, S Zenz, S Zerradi, D Zerwas, M Zhai, B Zhang, D F Zhang, J Zhang, J Zhang, K Zhang, L Zhang, P Zhang, R Zhang, S Zhang, S Zhang, T Zhang, X Zhang, X Zhang, Y Zhang, Y Zhang, Y Zhang, Z Zhang, Z Zhang, H Zhao, T Zhao, Y Zhao, Z Zhao, A Zhemchugov, J Zheng, K Zheng, X Zheng, Z Zheng, D Zhong, B Zhou, H Zhou, N Zhou, Y Zhou, Y Zhou, C G Zhu, J Zhu, Y Zhu, Y Zhu, X Zhuang, K Zhukov, V Zhulanov, N I Zimine, J Zinsser, M Ziolkowski, L Živković, A Zoccoli, K Zoch, T G Zorbas, O Zormpa, W Zou, L Zwalinski
This Letter presents the first study of Higgs boson production in association with a vector boson (V=W or Z) in the fully hadronic qqbb final state using data recorded by the ATLAS detector at the LHC in proton-proton collisions at sqrt[s]=13  TeV and corresponding to an integrated luminosity of 137  fb^{-1}. The vector bosons and Higgs bosons are each reconstructed as large-radius jets and tagged using jet substructure techniques. Dedicated tagging algorithms exploiting b-tagging properties are used to identify jets consistent with Higgs bosons decaying into bb[over ¯]...
March 29, 2024: Physical Review Letters
https://read.qxmd.com/read/38613168/immunological-and-hematological-findings-as-major-features-in-a-patient-with-a-new-germline-pathogenic-cbl-variant
#19
Emilia Stellacci, Jennefer N Carter, Luca Pannone, David Stevenson, Dorsa Moslehi, Serenella Venanzi, Jonathan A Bernstein, Marco Tartaglia, Simone Martinelli
Casitas B-lineage lymphoma (CBL) encodes an adaptor protein with E3-ligase activity negatively controlling intracellular signaling downstream of receptor tyrosine kinases. Somatic CBL mutations play a driver role in a variety of cancers, particularly myeloid malignancies, whereas germline defects in the same gene underlie a RASopathy having clinical overlap with Noonan syndrome (NS) and predisposing to juvenile myelomonocytic leukemia and vasculitis. Other features of the disorder include cardiac defects, postnatal growth delay, cryptorchidism, facial dysmorphisms, and predisposition to develop autoimmune disorders...
April 12, 2024: American Journal of Medical Genetics. Part A
https://read.qxmd.com/read/38613093/persistent-food-insecurity-and-material-hardships-a-latent-class-analysis-of-experiences-among-venezuelan-refugees-and-migrants-in-urban-colombia
#20
JOURNAL ARTICLE
Andrea L Wirtz, Megan Stevenson, José Rafael Guillén, Jennifer Ortiz, Miguel Ángel Barriga Talero, Kathleen R Page, Jhon Jairo López, Jhon Fredy Ramirez Correa, Damary Martínez Porras, Ricardo Luque Núñez, Julián Alfredo Fernández-Niño, Paul B Spiegel
The causes and conditions of displacement often increase the vulnerability of migrant and refugee populations to food insecurity, alongside other material hardships. We aimed to examine the multidimensional aspects and patterns of food insecurity and other material hardships in a cross-sectional sample of 6221 Venezuelan refugees and migrants in urban Colombia using a latent class analysis. Using multinomial and logistic regression models, we investigated the demographic and migratory experiences associated with identified classes and how class membership is associated with multiple health outcomes among Venezuelan refugees and migrants, respectively...
April 4, 2024: Nutrients
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