Kristina Nešporová, Jana Matonohová, Jarmila Husby, Evgeniy Toropitsyn, Lenka Divoká Stupecká, Aaron Husby, Tereza Suchánková Kleplová, Alexandra Streďanská, Matěj Šimek, David Nečas, Martin Vrbka, Robert Schleip, Vladimír Velebný
Hyaluronan (HA) has been recently identified as a key component of the densification of thoracolumbar fascia (TLF), a potential contributor to non-specific lower back pain (LBP) currently treated with manual therapy and systemic or local delivery of anti-inflammatory drugs. The aim of this study was to establish a novel animal model suitable for studying ultrasound-guided intrafascial injection prepared from HA with low and high Mw. Effects of these preparations on the profibrotic switch and mechanical properties of TLF were measured by qPCR and rheology, respectively, while their lubricating properties were evaluated by tribology...
September 12, 2023: International Journal of Biological Macromolecules