Anthony C Gordon, Narges Alipanah-Lechner, Lieuwe D Bos, Jose Dianti, Janet Victoria Diaz, Simon Finfer, Tomoko Fujii, Evangelos J Giamarellos-Bourboulis, Ewan C Goligher, Michelle Ng Gong, Eleni Karakike, Vincent Liu, Nuttha Lumlertgul, John C Marshall, David K Menon, Nuala J Meyer, Elizabeth S Munroe, Sheila N Myatra, Marlies Ostermann, Hallie C Prescott, Adrienne G Randolph, Edward J Schenck, Christopher W Seymour, Manu Shankar-Hari, Mervyn Singer, Marry R Smit, Aiko Tanaka, Fabio Silvio Taccone, B Taylor Thompson, Lisa K Torres, Tom Van der Poll, Jean-Louis Vincent, Carolyn S Calfee
Critical care uses syndromic definitions to describe patient groups for clinical practice and research. There is growing recognition that a "precision medicine" approach is required and that integrated biologic and physiologic data identify reproducible subpopulations that may respond differently to treatment. This article reviews the current state of the field and considers how to successfully transition to a precision medicine approach. In order to impact clinical care, identified subpopulations must do more than differentiate prognosis...
April 30, 2024: American Journal of Respiratory and Critical Care Medicine