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JOURNAL ARTICLE
Tara Arndt, Monika Keresztes, Blanck Olivier, L Boone, Franck Chanut, D Ennulat, Ellen Evans, Alexius Freyberger, S Johannes, C Frieke Kuper, Pierre Maliver, Peter O'Brien, Lila Ramaiah, Ian Roman, Volker Strauss, Petra Vinken, Dana Walker, Michael Winter, Gabriele Pohlmeyer-Esch, Lindsay Tomlinson
The European Society of Toxicologic Pathology (ESTP) organized a panel of 24 international experts from many fields of toxicologic clinical pathology (e.g., industry, academia, and regulatory) that came together in 2021 to align the use of terminology to convey the importance of clinical pathology findings in preclinical toxicity studies. An additional goal consisted of how to identify important findings in standard and nonstandard clinical pathology associated endpoints. This manuscript summarizes the information and opinions discussed and shared at the ninth ESTP International Expert Workshop, April 5 to 6, 2022...
April 25, 2024: Toxicologic Pathology
#2
Isabella C Glitza Oliva, Sherise D Ferguson, Roland Bassett, Alexandra P Foster, Ida John, Tarin D Hennegan, Michelle Rohlfs, Jessie Richard, Masood Iqbal, Tina Dett, Carol Lacey, Natalie Jackson, Theresa Rodgers, Suzanne Phillips, Sheila Duncan, Lauren Haydu, Ruitao Lin, Rodabe N Amaria, Michael K Wong, Adi Diab, Cassian Yee, Sapna P Patel, Jennifer L McQuade, Grant M Fischer, Ian E McCutcheon, Barbara J O'Brien, Sudhakar Tummala, Matthew Debnam, Nandita Guha-Thakurta, Jennifer A Wargo, Fernando C L Carapeto, Courtney W Hudgens, Jason T Huse, Michael T Tetzlaff, Elizabeth M Burton, Hussein A Tawbi, Michael A Davies
No abstract text is available yet for this article.
April 22, 2024: Nature Medicine
#3
JOURNAL ARTICLE
Sukwoo Hong, Yuki Shinya, Nikita Lakomkin, Anita Mahajan, Nadia N Laack, Erin O'Brien, Janalee K Stokken, Jeffrey R Janus, Carlos Pinheiro Neto, Garret W Choby, Maria Peris Celda, Michael J Link, Benjamin D Elder, Jamie J Van Gompel
OBJECTIVE: To assess the impact of tumor extension into the occipital condyle (OC) in lower clival chordoma management and the need for occipito-cervical fusion (OCF). METHODS: A retrospective analysis was conducted on 35 patients with lower clival chordoma. The preoperative area of the intact OCs, Hounsfield units, and the integrity of the apical ligament and the tectorial membrane were assessed using preoperative imaging. RESULTS: Seven (20%) patients were in the OCF group...
April 20, 2024: World Neurosurgery
#4
JOURNAL ARTICLE
Michael C O'Brien, Kyle J Kelleran, Susan J Burnett, Kaylee A Hausrath, Mary S Kneer, Nan Nan, Chang-Xing Ma, Robert W McCartin, Brian M Clemency
INTRODUCTION: Patients exhibiting signs of hyperactive delirium with severe agitation (HDSA) may require sedating medications for stabilization and safe transport to the hospital. Determining the patient's weight and calculating the correct weight-based dose may be challenging in an emergency. A fixed dose ketamine protocol is an alternative to the traditional weight-based administration, which may also reduce dosing errors. The objective of this study was to evaluate the frequency and characteristics of adverse events following pre-hospital ketamine administration for HDSA...
April 9, 2024: American Journal of Emergency Medicine
#5
REVIEW
Liam A Peebles, Nigel O Blackwood, Arjun Verma, Michael J O'Brien, David M Lintner, Matthew J Kraeutler
PURPOSE: To perform a systematic review evaluating clinical outcomes in patients undergoing medial ulnar collateral ligament reconstruction (MUCLR) with soft tissue allograft. METHODS: A systematic review of the literature was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The primary outcomes evaluated were patient-reported outcome scores, return to play (RTP) rates, incidence of postoperative complications, and rates of graft rupture or mechanical failure...
April 7, 2024: Arthroscopy
#6
JOURNAL ARTICLE
Jessica Robinson-Papp, Steven Lawrence, Antonia Wadley, Whitney Scott, Mary Catherine George, Jo Josh, Kelly K O'Brien, Collen Price, Lisa Uebelacker, E Jennifer Edelman, Michael Evangeli, Burel R Goodin, Richard Harding, Kennedy Nkhoma, Romy Parker, Caroline Sabin, Deepika Slawek, Judith I Tsui, Jessica S Merlin
The Global Task Force on Chronic Pain in HIV published seven research priorities in the field of HIV-associated chronic pain in 2019: (1) causes; (2) management; (3) treatment individualization and integration with addiction treatment; (4) mental and social health factors; (5) prevalence; (6) treatment cost effectiveness; and (7) prevention. The current study used a web-based survey to determine whether the research topics were aligned with the priorities of adults with lived experiences of HIV and chronic pain...
April 8, 2024: AIDS Care
#7
JOURNAL ARTICLE
Siddharth M Patel, David D Berg, Erin A Bohula, Vivan M Baird-Zars, Gregory W Barsness, Sunit-Preet Chaudhry, Meshe D Chonde, Howard A Cooper, Curtis Ginder, Jacob C Jentzer, Michael C Kontos, P Elliott Miller, L Kristin Newby, Connor G O'Brien, Jeong-Gun Park, Matthew J Pierce, Barbara A Pisani, Brian J Potter, Kevin S Shah, Jeffrey J Teuteberg, Jason N Katz, Sean van Diepen, David A Morrow
Background: Associations of early changes in vasoactive support with cardiogenic shock (CS) mortality remain incompletely defined. Methods: The Critical Care Cardiology Trials Network is a multicenter registry of cardiac intensive care units (CICUs). Patients admitted with CS (2018-2023) had vasoactive dosing assessed at 4 and 24 hours (h) from CICU admission and quantified by the vasoactive-inotropic score (VIS). Prognostic associations of VIS at both timepoints, as well as change in VIS from 4h to 24h, were examined...
April 8, 2024: Circulation. Heart Failure
#8
JOURNAL ARTICLE
Christian Renaud, Antoine Lewin, Yves Gregoire, Nathalie Simard, Émilie Vallières, Maude Paquette, Steven J Drews, Sheila F O'Brien, Clara Di Germanio, Michael P Busch, Marc Germain, Renée Bazin
BACKGROUND AND OBJECTIVES: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serosurveys are typically analysed by applying a fixed threshold for seropositivity ('conventional approach'). However, this approach underestimates the seroprevalence of anti-nucleocapsid (N) in vaccinated individuals-who often exhibit a difficult-to-detect anti-N response. This limitation is compounded by delays between the onset of infection and sample collection. To address this issue, we compared the performance of four immunoassays using a new analytical approach ('ratio-based approach'), which determines seropositivity based on an increase in anti-N levels...
April 5, 2024: Vox Sanguinis
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JOURNAL ARTICLE
James A Ward, Said I Ng'ang'a, Imtiaz A S Randhawa, Gillian P McHugo, John F O'Grady, Julio M Flórez, John A Browne, Ana M Pérez O'Brien, Antonio J Landaeta-Hernández, Jóse F Garcia, Tad S Sonstegard, Laurent A F Frantz, Michael Salter-Townshend, David E MacHugh
Criollo cattle, the descendants of animals brought by Iberian colonists to the Americas, have been the subject of natural and human-mediated selection in novel tropical agroecological zones for centuries. Consequently, these breeds have evolved distinct characteristics such as resistance to diseases and exceptional heat tolerance. In addition to European taurine ( Bos taurus ) ancestry, it has been proposed that gene flow from African taurine and Asian indicine ( Bos indicus ) cattle has shaped the ancestry of Criollo cattle...
March 2024: Royal Society Open Science
#10
JOURNAL ARTICLE
Claire F Smith, Danya Stone, Ross Munro, Aiden Jayanth, Catherine M Hennessy, Dominic O'Brien, Camilla Ingram, Geetika Ail, Michael Koenig, Laura Arnold, Matthew Bemment, Malcolm Johnston
Recently, there has been an emphasis on keeping the study of anatomy using donor material confined to the domain of medical and allied healthcare professionals. Given the abundance of both accurate and inaccurate information online, coupled with a heightened focus on health following the COVID-19 pandemic, one may question whether it is time to review who can access learning anatomy using donors. In 2019, Brighton and Sussex Medical School (BSMS) obtained a Human Tissue Authority Public Display license with the aim of broadening the reach of who could be taught using donor material...
March 31, 2024: Anatomical Sciences Education
#11
JOURNAL ARTICLE
Fae Kayarian, Daven Patel, James R O'Brien, Evelyn K Schraft, Michael Gottlieb
The utilization of artificial intelligence (AI) in medical imaging has become a rapidly growing field as a means to address contemporary demands and challenges of healthcare. Among the emerging applications of AI is point-of-care ultrasound (POCUS), in which the combination of these two technologies has garnered recent attention in research and clinical settings. In this Controversies paper, we will discuss the benefits, limitations, and future considerations of AI in POCUS for patients, clinicians, and healthcare systems...
March 25, 2024: American Journal of Emergency Medicine
#12
JOURNAL ARTICLE
Helen M Faddy, Carla Osiowy, Brian Custer, Michael Busch, Susan L Stramer, Melinda M Dean, Jessika Acutt, Elvina Viennet, Thijs van de Laar, Wai-Chiu Tsoi, Claire Styles, Phil Kiely, Angelo Margaritis, So-Yong Kwon, Yan Qiu, Xuelian Deng, Antoine Lewin, Signe Winther Jørgensen, Christian Erikstrup, David Juhl, Silvia Sauleda, Bernardo Armando Camacho Rodriguez, Lisbeth Jennifer Catherine Soto Coral, Paula Andrea Gaviria García, Sineenart Oota, Sheila F O'Brien, Silvano Wendel, Emma Castro, Laura Navarro Pérez, Heli Harvala, Katy Davison, Claire Reynolds, Lisa Jarvis, Piotr Grabarczyk, Aneta Kopacz, Magdalena Łętowska, Niamh O'Flaherty, Fiona Young, Padraig Williams, Lisa Burke, Sze Sze Chua, An Muylaert, Isabel Page, Ann Jones, Christoph Niederhauser, Marion Vermeulen, Syria Laperche, Pierre Gallian, Masahiro Satake, Marcelo Addas-Carvalho, Sebastián Blanco, Sandra V Gallego, Axel Seltsam, Marijke Weber-Schehl, Arwa Z Al-Riyami, Khuloud Al Maamari, Fatma Ba Alawi, Hem Chandra Pandey, Rochele Azevedo França, Richard Charlewood
BACKGROUND AND OBJECTIVES: Nucleic acid-amplification testing (NAT) is used for screening blood donations/donors for blood-borne viruses. We reviewed global viral NAT characteristics and NAT-yield confirmatory testing used by blood operators. MATERIALS AND METHODS: NAT characteristics and NAT-yield confirmatory testing used during 2019 was surveyed internationally by the International Society of Blood Transfusion Working Party Transfusion-Transmitted Infectious Diseases...
March 22, 2024: Vox Sanguinis
#13
JOURNAL ARTICLE
Nicholas O Gerard, Sean C Clark, Michael J O'Brien, Mary K Mulcahey, Felix H Savoie
BACKGROUND: Ulnar collateral ligament (UCL) reconstruction has been the standard surgical intervention for elite male athletes with UCL insufficiency. Recently, UCL repair and augmentation with an internal brace has been increasingly performed. PURPOSE: To evaluate the clinical and functional outcomes as well as return-to-sport rate after UCL repair in female athletes. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: Included were 15 female athletes (mean age, 16...
March 2024: Orthopaedic Journal of Sports Medicine
#14
JOURNAL ARTICLE
John Kappelman, Lawrence C Todd, Christopher A Davis, Thure E Cerling, Mulugeta Feseha, Abebe Getahun, Racheal Johnsen, Marvin Kay, Gary A Kocurek, Brett A Nachman, Agazi Negash, Tewabe Negash, Kaedan O'Brien, Michael Pante, Minghua Ren, Eugene I Smith, Neil J Tabor, Dereje Tewabe, Hong Wang, Deming Yang, Solomon Yirga, Jordan W Crowell, Matthew F Fanuka, Teshager Habtie, Jayde N Hirniak, Carla Klehm, Natalia D Loewen, Sahleselasie Melaku, Sierra M Melton, Timothy S Myers, Sarah Millonig, Megan C Plummer, Keenan J Riordan, Nicholas A Rosenau, Anne Skinner, Abraham K Thompson, Lindsey M Trombetta, Adrienne Witzel, Ephrem Assefa, Maria Bodansky, Ayenachew A Desta, Christopher J Campisano, Daniel Dalmas, Connor Elliott, Metasebia Endalamaw, Nicholas J Ford, Frederick Foster, Tomas Getachew, Yibai Li Haney, Brittney H Ingram, Jonayah Jackson, Curtis W Marean, Sissi Mattox, Karla de la Cruz Medina, Gebretsadkan Mulubrhan, Keri Porter, Alexis Roberts, Perla Santillan, Alaric Sollenberger, Julia Sponholtz, Jessica Valdes, Lani Wyman, Meklit Yadeta, Sierra Yanny
Although modern humans left Africa multiple times over 100,000 years ago, those broadly ancestral to non-Africans dispersed less than 100,000 years ago1 . Most models hold that these events occurred through green corridors created during humid periods because arid intervals constrained population movements2 . Here we report an archaeological site-Shinfa-Metema 1, in the lowlands of northwest Ethiopia, with Youngest Toba Tuff cryptotephra dated to around 74,000 years ago-that provides early and rare evidence of intensive riverine-based foraging aided by the likely adoption of the bow and arrow...
March 20, 2024: Nature
#15
JOURNAL ARTICLE
Ziyaad Dangor, Nicole Benson, James A Berkley, Julia Bielicki, Merijn W Bijsma, Jonathan Broad, Ed T Buurman, Alan Cross, Erin M Duffy, Kathryn E Holt, Pui-Ying Iroh Tam, Mark Jit, Konstantinos Karampatsas, Michael Katwere, Gaurav Kwatra, Ramanan Laxminarayan, Kirsty Le Doare, Robert Mboizi, Francesca Micoli, Catrin E Moore, Eve Nakabembe, Nichola R Naylor, Seamus O'Brien, Courtney Olwagen, Denasha Reddy, Charlene Rodrigues, David A Rosen, Manish Sadarangani, Padmini Srikantiah, Sharon M Tennant, Mateusz Hasso-Agopsowicz, Shabir A Madhi
Klebsiella pneumoniae causes community- and healthcare-associated infections in children and adults. Globally in 2019, an estimated 1.27 million (95% Uncertainty Interval [UI]: 0.91-1.71) and 4.95 million (95% UI: 3.62-6.57) deaths were attributed to and associated with bacterial antimicrobial resistance (AMR), respectively. K. pneumoniae was the second leading pathogen in deaths attributed to AMR resistant bacteria. Furthermore, the rise of antimicrobial resistance in both community- and hospital-acquired infections is a concern for neonates and infants who are at high risk for invasive bacterial disease...
March 18, 2024: Vaccine
#16
JOURNAL ARTICLE
Robert J Carton, Michael G Doyle, Hugh Kearney, Charles A Steward, Nicholas J Lench, Anthony Rogers, Erin L Heinzen, Seamus McDonald, Joanna Fay, Austin Lacey, Alan Beausang, Jane Cryan, Francesca Brett, Hany El-Naggar, Peter Widdess-Walsh, Daniel Costello, Ronan Kilbride, Colin P Doherty, Kieron J Sweeney, Donncha F O'Brien, David C Henshall, Norman Delanty, Gianpiero L Cavalleri, Katherine A Benson
OBJECTIVE: The contribution of somatic variants to epilepsy has recently been demonstrated, particularly in the etiology of malformations of cortical development. The aim of this study was to determine the diagnostic yield of somatic variants in genes that have been previously associated with a somatic or germline epilepsy model, ascertained from resected brain tissue from patients with multidrug-resistant focal epilepsy. METHODS: Forty-two patients were recruited across three categories: (1) malformations of cortical development, (2) mesial temporal lobe epilepsy with hippocampal sclerosis, and (3) nonlesional focal epilepsy...
March 16, 2024: Epilepsia
#17
JOURNAL ARTICLE
Lei Wang, Michael T O'Brien, Xinmeng Zhang, You Chen, Wayne J English, Brandon Williams, Matthew Spann, Vance Albaugh, Xiao-Ou Shu, Charles R Flynn, Danxia Yu
CONTEXT: Metabolic surgery remains the most effective and durable treatment for severe obesity and related metabolic diseases. OBJECTIVE: We examined cardiometabolic improvements after metabolic surgery and associated presurgery demographic and clinical factors in a large multiracial cohort. METHODS: Included were 7804 patients (20-79 years) undergoing first-time metabolic surgery at Vanderbilt University Medical Center from 1999 to 2022. Pre- and 1-year postsurgery cardiometabolic profiles were extracted from medical records, including body mass index (BMI), blood pressure, blood lipids, glucose, and hemoglobin A1c...
March 12, 2024: Journal of the Endocrine Society
#18
JOURNAL ARTICLE
Faizal Z Asumda, Nellie A Campbell, Mohamed A Hassan, Reza Fathi, Daniella F Vasquez Rico, Melanie Kiem, Ethan V Vang, Yo Han Kim, Xin Luo, Daniel R O'Brien, Sarah A Buhrow, Joel M Reid, Michael J Moore, Vered Katz Ben-Yair, Mark L Levitt, Jennifer L Leiting, Amro M Abdelrahman, Xinli Zhu, Fabrice Lucien, Mark J Truty, Lewis R Roberts
Upamostat is an orally available small-molecule serine protease inhibitor that is a highly potent inhibitor of trypsin 1, trypsin 2, trypsin 3 (PRSS1/2/3), and the urokinase-type plasminogen activator (uPA). These enzymes are expressed in many cancers, especially during tissue remodeling and subsequent tumor cell invasion. Opaganib (ABC294640), a novel, orally available small molecule is a selective inhibitor of the phosphorylation of sphingosine to sphingosine-1-phosphate (S-1-P) by sphingosine kinase 2 (SPHK2)...
March 5, 2024: Cancers
#19
JOURNAL ARTICLE
David C Bartholomew, Robin Hayward, David F R P Burslem, Paulo R L Bittencourt, Daniel Chapman, Mohd Aminur Faiz Bin Suis, Reuben Nilus, Michael J O'Brien, Glen Reynolds, Lucy Rowland, Lindsay F Banin, Daisy Dent
Active restoration through silvicultural treatments (enrichment planting, cutting climbers and liberation thinning) is considered an important intervention in logged forests. However, its ability to enhance regeneration is key for long-term recovery of logged forests, which remains poorly understood, particularly for the production and survival of seedlings in subsequent generations. To understand the long-term impacts of logging and restoration we tracked the diversity, survival and traits of seedlings that germinated immediately after a mast fruiting in North Borneo in unlogged and logged forests 30-35 years after logging...
March 2024: Global Change Biology
#20
EDITORIAL
Harris A Eyre, William Hynes, Rym Ayadi, Pawel Swieboda, Michael Berk, Agustin Ibanez, María E Castelló, Dilip V Jeste, Michelle Tempest, Jafri Malin Abdullah, Kelly O'Brien, Steve Carnevale, Alfred K Njamnshi, Michael Martino, Dan Mannix, Katrina Maestri, Ruojuan Yu, Shuo Chen, Chee H Ng, Heinrich C Volmink, Rajiv Ahuja, Frederic Destrebecq, George Vradenburg, Astrid Schmied, Facundo Manes, Michael L Platt
The coming years are likely to be turbulent due to a myriad of factors or polycrisis, including an escalation in climate extremes, emerging public health threats, weak productivity, increases in global economic instability and further weakening in the integrity of global democracy. These formidable challenges are not exogenous to the economy but are in some cases generated by the system itself. They can be overcome, but only with far-reaching changes to global economics. Our current socio-economic paradigm is insufficient for addressing these complex challenges, let alone sustaining human development, well-being and happiness...
February 2024: Malaysian Journal of Medical Sciences: MJMS
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