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JOURNAL ARTICLE
Eduard Shantsila, D Gareth Beevers, Gregory Y H Lip
Originally, the beta-blockers were equally ranked alongside the other antihypertensive drug classes. Things changed when two major long-term randomized controlled trials, ASCOT-BPLA and LIFE showed that the patients receiving the beta-blockers based regimes suffered 25-30% more strokes than those receiving a calcium channel blocker based regime or an angiotensin receptor blocker based regime. The inferiority of the beta-blockers at stroke prevention was not due to differences in blood pressure control during the follow-up period in both trials...
April 15, 2024: Journal of Hypertension
#2
JOURNAL ARTICLE
Weiyi Wang, John Gulliver, Sean Beevers, Anna Freni Sterrantino, Bethan Davies, Richard W Atkinson, Daniela Fecht
BACKGROUND: There is an increasing body of evidence associating short-term ambient nitrogen dioxide (NO2 ) exposure with asthma-related hospital admissions in children. However, most studies have relied on temporally resolved exposure information, potentially ignoring the spatial variability of NO2 . We aimed to investigate how daily NO2 estimates from a highly resolved spatio-temporal model are associated with the risk of emergency hospital admission for asthma in children in England...
2024: Journal of Asthma and Allergy
#3
JOURNAL ARTICLE
Dylan Wood, Dimitris Evangelopoulos, Sean Beevers, Nutthida Kitwiroon, Panayotes Demakakos, Klea Katsouyanni
BACKGROUND: An increasing number of studies suggest adverse effects of exposure to ambient air pollution on cognitive function, but the evidence is still limited. We investigated the associations between long-term exposure to air pollutants and cognitive function in the English Longitudinal Study of Ageing (ELSA) cohort of older adults. METHODS: Our sample included 8,883 individuals from ELSA, based on a nationally representative study of people aged ≥ 50 years, followed-up from 2002 until 2017...
April 5, 2024: Environmental Health
#4
JOURNAL ARTICLE
Maria Elisa Caetano-Silva, Laurie Rund, Mario Vailati-Riboni, Stephanie Matt, Katiria Soto-Diaz, Jon Beever, Jacob M Allen, Jeffrey A Woods, Andrew J Steelman, Rodney W Johnson
Gut inflammation can trigger neuroinflammation and is linked to mood disorders. Microbiota-derived short-chain fatty acids (SCFAs) can modulate microglia, yet the mechanism remains elusive. Since microglia do not express free-fatty acid receptor (FFAR)2, but intestinal epithelial cells (IEC) and peripheral myeloid cells do, we hypothesized that SCFA-mediated FFAR2 activation within the gut or peripheral leukocytes may impact microglia inflammation. To test this hypothesis, we developed a tamoxifen-inducible conditional knockout mouse model targeting FFAR2 exclusively on IEC and induced intestinal inflammation with dextran sodium sulfate (DSS), a well-established colitis model...
March 9, 2024: Brain, Behavior, and Immunity
#5
JOURNAL ARTICLE
Hannah McInnes-Dean, Rhiannon Mellis, Morgan Daniel, Holly Walton, Emma L Baple, Marta Bertoli, Jane Fisher, Katarzyna Gajewska-Knapik, Muriel Holder-Espinasse, Caroline Lafarge, Kerry Leeson-Beevers, Alec McEwan, Pranav Pandya, Michael Parker, Sophie Peet, Lauren Roberts, Srividhya Sankaran, Audrey Smith, Dagmar Tapon, Wing Han Wu, Sarah L Wynn, Lyn S Chitty, Melissa Hill, Michelle Peter
OBJECTIVES: In October 2020, rapid prenatal exome sequencing (pES) was introduced into routine National Health Service (NHS) care in England. This study aimed to explore parent experiences and their information and support needs from the perspective of parents offered pES and of health professionals involved in its delivery. METHODS: In this qualitative study, semi-structured interviews were conducted with 42 women and 6 male partners and 63 fetal medicine and genetic health professionals...
March 5, 2024: Prenatal Diagnosis
#6
JOURNAL ARTICLE
Rachel R Reith, Jonathan E Beever, Joe C Paschal, Jason Banta, Brian F Porter, David J Steffen, Thomas B Hairgrove, Jessica L Petersen
Bovine familial convulsions and ataxia (BFCA) is considered an autosomal dominant syndrome with incomplete penetrance. Nine Angus calves from the same herd were diagnosed with BFCA within days of birth. Necropsy revealed cerebellar and spinal cord lesions associated with the condition. Parentage testing confirmed that all affected calves had a common sire. The sire was then bred to 36 cows across two herds using artificial insemination, producing an additional 14 affected calves. The objective of this investigation was to identify hypothesized dominant genetic variation underlying the condition...
March 1, 2024: Animal Genetics
#7
JOURNAL ARTICLE
Sarah Barth, Colin Edwards, Rebecca Borton, Dan Beever, Wendy Adams, Gisli Jenkins, Elena Pizzo, Iain Stewart, Melissa Wickremasinghe
INTRODUCTION: Remote monitoring of home physiological measurements has been proposed as a solution to support patients with chronic diseases as well as facilitating virtual consultations and pandemic preparedness for the future. Daily home spirometry and pulse oximetry have been demonstrated to be safe and acceptable to patients with interstitial lung disease (ILD) but there is currently limited evidence to support its integration into clinical practice. AIM: Our aim is to understand the clinical utility of frequent remote physiological measurements in ILD and the impact of integrating these into clinical practice from a patient, clinical and health economic perspective...
February 28, 2024: BMJ Open Respiratory Research
#8
JOURNAL ARTICLE
David M Theobald, Aerin L Jacob, Paul R Elsen, Erik A Beever, Libby Ehlers, Jodi Hilty
Conserving mountains is important for protecting biodiversity because they have high beta diversity and endemicity, facilitate species movement, and provide numerous ecosystem benefits for people. Mountains are often thought to have lower levels of human modification and contain more protected area than surrounding lowlands. To examine this, we compared biogeographic attributes of the largest, contiguous, mountainous region on each continent. In each region, we generated detailed ecosystems based on Köppen-Geiger climate regions, ecoregions, and detailed landforms...
February 26, 2024: Conservation Biology
#9
JOURNAL ARTICLE
Letizia Rasica, Erin Calaine Inglis, Raffaele Mazzolari, Danilo Iannetta, Juan M Murias
PURPOSE: Different strategies for near-infrared spectroscopy (NIRS)-derived muscle oxidative capacity assessment have been reported. This study compared and evaluated (I) approaches for averaging trials; (II) NIRS signals and blood volume correction equations; (III) the assessment of vastus lateralis (VL) and tibialis anterior (TA) muscles in two fitness levels groups. METHODS: Thirty-six participants [18 chronically trained (CT: 14 males, 4 females) and 18 untrained (UT: 10 males, 8 females)] participated in this study...
February 24, 2024: European Journal of Applied Physiology
#10
REVIEW
Katie Jarvis, Anna Cartledge, Sarah Martin, Candi Lawson, Marissa Palmer, Vicki Beevers, Heather E Elphick
Sleep deprivation has a serious impact on physical and mental health. Children with neurodevelopmental disorders are frequently affected by chronic insomnia, defined as difficulty in either initiating sleep, maintaining sleep continuity or poor sleep quality which can lead to long-term detrimental effects on behaviour, learning and development.Interventions to address chronic insomnia in children include both pharmacological and non-pharmacological approaches. While some children unequivocally benefit from pharmacological treatment, recommendations suggest an intervention based on cognitive-behavioural techniques involving a thorough assessment of the child's sleep pattern, environment and psychosocial factors supporting the child to learn to self-soothe as first-line treatment...
February 12, 2024: Archives of Disease in Childhood
#11
JOURNAL ARTICLE
Fabian A Soto, Christopher G Beevers
BACKGROUND: Deficits in face emotion recognition are well-documented in depression, but the underlying mechanisms are poorly understood. Psychophysical observer models provide a way to precisely characterize such mechanisms. Using model-based analyses, we test two hypotheses about how depression might reduce sensitivity to detect face emotion: via a change in selectivity for visual information diagnostic of emotion, versus a change in signal-to-noise ratio in the system performing emotion detection...
February 7, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
#12
JOURNAL ARTICLE
Wenxing Han, Jin Zhang, Zhihu Xu, Teng Yang, Jing Huang, Sean Beevers, Frank Kelly, Guoxing Li
BACKGROUND: Arterial stiffness (AS) is an important predicting factor for cardiovascular disease. However, no epidemiological studies have ever explored the mediating role of biomarkers in the association between ozone and AS, nor weather fish oil modified such association. METHODS: Study participants were drawn from the UK biobank, and a total of 95,699 middle-aged and older adults were included in this study. Ozone was obtained from Community Multiscale Air Quality (CMAQ) model matched to residential addresses, fish oil from self-reported intake, and arterial stiffness was based on device measurements...
February 5, 2024: Environmental Research
#13
JOURNAL ARTICLE
Rachel L Weisenburger, Michael C Mullarkey, Jocelyn Labrada, Daniel Labrousse, Michelle Y Yang, Allison Huff MacPherson, Kean J Hsu, Hassan Ugail, Jason Shumake, Christopher G Beevers
BACKGROUND: Depression is prevalent, chronic, and burdensome. Due to limited screening access, depression often remains undiagnosed. Artificial intelligence (AI) models based on spoken responses to interview questions may offer an effective, efficient alternative to other screening methods. OBJECTIVE: The primary aim was to use a demographically diverse sample to validate an AI model, previously trained on human-administered interviews, on novel bot-administered interviews, and to check for algorithmic biases related to age, sex, race, and ethnicity...
January 28, 2024: Journal of Affective Disorders
#14
JOURNAL ARTICLE
Paul Fowler, Alessandra Bearzatto, Carol Beevers, Ewan Booth, E Maria Donner, Lin Gan, Kerstin Hartmann, Krista Meurer, Maaike E Schutte, Raja S Settivari
The two-test in vitro battery for genotoxicity testing (Ames and micronucleus) has, in the majority of cases replaced the three-test battery (as two test plus mammalian cell gene mutation assay) for the routine testing of chemicals, pharmaceuticals, cosmetics and agrochemical metabolites originating from food and feed as well as from water treatment. The guidance for testing of agrochemical groundwater metabolites, however, still relies on the three-test battery. Data collated in this study from eighteen plant protection and related materials highlights the disparity between the often negative Ames and in vitro chromosome aberration data and frequently positive in vitro mammalian cell gene mutation assays...
January 6, 2024: Mutagenesis
#15
JOURNAL ARTICLE
Monireh Asoudeh, Nicole Nguyen, Mitch Raith, Desiree S Denman, Uche C Anozie, Mahshid Mokhtarnejad, Bamin Khomami, Kaitlyn M Skotty, Sami Isaac, Taylor Gebhart, Lauren Vaigneur, Aga Gelgie, Oudessa Kerro Dego, Trevor Freeman, Jon Beever, Paul Dalhaimer
Poly-ethylene-glycol (PEG)-based nanoparticles (NPs) - including cylindrical micelles (CNPs), spherical micelles (SNPs), and PEGylated liposomes (PLs) - are hypothesized to be cleared in vivo by opsonization followed by liver macrophage phagocytosis. This hypothesis has been used to explain the rapid and significant localization of NPs to the liver after administration into the mammalian vasculature. Here, we show that the opsonization-phagocytosis nexus is not the major factor driving PEG-NP - macrophage interactions...
December 18, 2023: Journal of Controlled Release
#16
JOURNAL ARTICLE
Anette Loeffler, Lee Beever, Yu-Mei Chang, Babette Klein, Veit Kostka, Cornelia Meyer, Elisabeth Müller, Jessica Weis, Brett Wildermuth, John Fishwick, David H Lloyd
BACKGROUND: Legislation was introduced in Germany in 2018, requiring bacterial culture and antimicrobial susceptibility testing before the prescription of fluoroquinolones and third-generation cephalosporins to dogs. We hypothesised that, following this intervention, the number of clinical samples testing positive for methicillin-resistant Staphylococcus pseudintermedius (MRSP) would reduce. METHODS: Reports of S. pseudintermedius isolated from canine clinical samples by three German veterinary diagnostic microbiology laboratories during the 38 months before the introduction of the legislation and the 46 months after were compared...
December 15, 2023: Veterinary Record
#17
JOURNAL ARTICLE
Anne-Katharina Deisenhofer, Michael Barkham, Esther T Beierl, Brian Schwartz, Katie Aafjes-van Doorn, Christopher G Beevers, Isabel M Berwian, Simon E Blackwell, Claudi L Bockting, Eva-Lotta Brakemeier, Gary Brown, Joshua E J Buckman, Louis G Castonguay, Claire E Cusack, Tim Dalgleish, Kim de Jong, Jaime Delgadillo, Robert J DeRubeis, Ellen Driessen, Jill Ehrenreich-May, Aaron J Fisher, Eiko I Fried, Jessica Fritz, Toshi A Furukawa, Claire M Gillan, J M Gómez Penedo, Peter F Hitchcock, Stefan G Hofmann, Steven D Hollon, Nicholas C Jacobson, Daniel R Karlin, Chi Tak Lee, Cheri A Levinson, Lorenzo Lorenzo-Luaces, Riley McDanal, Danilo Moggia, Mei Yi Ng, Lesley A Norris, Vikram Patel, Marilyn L Piccirillo, Stephen Pilling, Julian A Rubel, Gonzalo Salazar-de-Pablo, Jessica L Schleider, Paula P Schnurr, Stephen M Schueller, Greg J Siegle, Rudolf Uher, Ed Watkins, Christian A Webb, Shannon Wiltsey Stirman, Laure Wynants, Soo Jeong Youn, Sigal Zilcha-Mano, Wolfgang Lutz, Zachary D Cohen
No abstract text is available yet for this article.
December 1, 2023: Behaviour Research and Therapy
#18
JOURNAL ARTICLE
Jianbo Jin, Zhihu Xu, Sean D Beevers, Jing Huang, Frank Kelly, Guoxing Li
BACKGROUND: Evidence linking ozone to depression and anxiety disorders remains sparse and results are heterogeneous. It remains unknown whether omega-3 fatty acid, or genetic susceptibility of mental disorders modify the impacts of ozone. The aim is to assess the associations of ambient ozone with depression and anxiety, and further explore the potential modification effects of omega-3 fatty acid and genetic susceptibility. METHODS: In total of 257,534 participants were enrolled from 2006 to 2010 and followed up to 2016...
December 9, 2023: Environmental Research
#19
JOURNAL ARTICLE
Holly Walton, Pei Li Ng, Amy Simpson, Lara Bloom, Lyn S Chitty, Naomi J Fulop, Amy Hunter, Jennifer Jones, Joe Kai, Larissa Kerecuk, Maria Kokocinska, Kerry Leeson-Beevers, Sharon Parkes, Angus I G Ramsay, Alastair Sutcliffe, Christine Taylor, Stephen Morris
BACKGROUND: Poorly coordinated care can have major impacts on patients and families affected by rare conditions, with negative physical health, psychosocial and financial consequences. This study aimed to understand how care is coordinated for rare diseases in the United Kingdom. METHODS: We undertook a national survey in the UK involving 760 adults affected by rare diseases, 446 parents/carers of people affected by rare diseases, and 251 healthcare professionals who care for people affected by rare diseases...
November 23, 2023: Orphanet Journal of Rare Diseases
#20
JOURNAL ARTICLE
David Dajnak, Nosha Assareh, Nutthida Kitwiroon, Andrew V Beddows, Gregor B Stewart, William Hicks, Sean D Beevers
The recent United Kingdom (UK) Environment Act consultation had the intention of setting two targets for PM2.5 (particles with an aerodynamic diameter less than 2.5 μm), one related to meeting an annual average concentration and the second to reducing population exposure. As part of the consultation, predictions of PM2.5 concentrations in 2030 were made by combining European Union (EU) and UK government's emissions forecasts, with the Climate Change Committee's (CCC) Net Zero vehicle forecasts, and in London with the addition of local policies based on the London Environment Strategy (LES)...
September 28, 2023: Environment International
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