Murray Bruce Reed, Patricia Anna Handschuh, Clemens Schmidt, Matej Murgaš, David Gomola, Christian Milz, Sebastian Klug, Benjamin Eggerstorfer, Lisa Aichinger, Godber Mathis Godbersen, Lukas Nics, Tatjana Traub-Weidinger, Marcus Hacker, Rupert Lanzenberger, Andreas Hahn
PURPOSE: Functional PET (fPET) is a novel technique for studying dynamic changes in brain metabolism and neurotransmitter signaling. Accurate quantification of fPET relies on measuring the arterial input function (AIF), traditionally achieved through invasive arterial blood sampling. While non-invasive image-derived input functions (IDIF) offer an alternative, they suffer from limited spatial resolution and field of view. To overcome these issues, we developed and validated a scan protocol for brain fPET utilizing cardiac IDIF, aiming to mitigate known IDIF limitations...
April 27, 2024: European Journal of Nuclear Medicine and Molecular Imaging