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JOURNAL ARTICLE
Jan Fiala, Dina Schuster, Simon Ollivier, Stuart Pengelley, Markus Lubeck, Florian Busch, Andris Jankevics, Oliver Raether, Jean-Francois Greisch, Albert J R Heck
Endogenous antibodies, or immunoglobulins (Igs), abundantly present in body fluids, represent some of the most challenging samples to analyze, largely due to the immense variability in their sequences and concentrations. It has been estimated that our body can produce billions of different Ig proteins with different isotypes, making their individual analysis seemingly impossible. However, recent advances in protein-centric proteomics using LC-MS coupled to Orbitrap mass analyzers to profile intact Fab fragments formed by selective cleavage at the IgG-hinge revealed that IgG repertoires may be less diverse, albeit unique for each donor...
April 25, 2024: Journal of the American Society for Mass Spectrometry
#2
JOURNAL ARTICLE
Marijana R Pantović Pavlović, Nenad L Ignjatović, Senka Gudić, Ladislav Vrsalović, Katarina Đ Božić, Marko E Popović, Miroslav M Pavlović
Titanium (Ti) is widely used in medical and dental implants. Calcium phosphate (CPs) coatings enhance Ti implants' osteoinductive properties, and additives further improve these coatings. Recently, a nano amorphous calcium phosphate (nACP) coating decorated with chitosan oligolactate (ChOL) and selenium (Se) showed immunomodulatory effects. This study investigates the surface morphology, composition, bioactivity, mechanical properties, and Se-release mechanism of the nACP@ChOL-Se hybrid coating on Ti substrates...
April 25, 2024: Annals of Biomedical Engineering
#3
JOURNAL ARTICLE
Pablo Vinicius Novakoski, Maksuel Gatto de Vitt, Vitor Luiz Molosse, Ana Carolina Hadlich Xavier, Roger Wagner, Bruna Klein, Carine Freitas Milarch, Luiz Eduardo Leonardi, Gilberto Vilmar Kozloski, Marcelo Vedovatto, Aleksandro S da Silva
Incorporating Curcumin into animal diets holds significant promise for enhancing both animal health and productivity, with demonstrated positive impacts on antioxidant activity, anti-microbial responses. Therefore, this study aimed to determine whether adding Curcumin to the diet of dairy calves would influence ruminal fermentation, hematologic, immunological, oxidative, and metabolism variables. Fourteen Jersey calves were divided into a control group (GCON) and a treatment group (GTRA). The animals in the GTRA received a diet containing 65...
April 25, 2024: Tropical Animal Health and Production
#4
JOURNAL ARTICLE
Bo Xiang, Yiliu Li, M S Spencer, Yanan Dai, Yusong Bai, Dmitri N Basov, X-Y Zhu
An exciton-polariton condensate is a hybrid light-matter state in the quantum fluid phase. The photonic component endows it with characters of spin, as represented by circular polarization. Spin-polarization can form stochastically for quasi-equilibrium exciton-polariton condensates at parallel momentum vector k|| ∼ 0 from bifurcation or deterministically for propagating condensates at k|| > 0 from the optical spin-Hall effect (OSHE). Here, we report deterministic spin-polarization in exciton-polariton condensates at k|| ∼ 0 in microcavities containing methylammonium lead bromide perovskite (CH3NH3PbBr3) single crystals under non-resonant and linearly polarized excitation...
April 28, 2024: Journal of Chemical Physics
#5
JOURNAL ARTICLE
Suree Yoowannakul, Surachet Vongsanim, Kamonwan Tangvoraphonkchai, Andrew Davenport
INTRODUCTION: Hemodialysis patient groups have advocated reducing dialysis fatigue and symptoms. We investigated whether compartmental fluid shifts were associated with peri-dialytic fatigue and symptoms. METHODS: Sessional dialysis records of patients reporting both a short and delayed recovery (<1 h and ≥1 h) with corresponding bioimpedance measurements were reviewed. RESULTS: One hundred and twenty-four patients reported both short and delayed recovery times, mean age 66...
April 25, 2024: Therapeutic Apheresis and Dialysis
#6
JOURNAL ARTICLE
Mohammad A Shafiee, Amireza Goli, Pouyan Shaker, Vishal Sharma, Yasmin Shahideh, Khrystyna Maryniak, Behrooz Broumand
In this brief communication, we reemphasize the importance of critical thinking in clinical practice using the example of edema. The common practice of thinking and inquiry by practicing clinicians has beneficial implications for healthcare by improving outcomes and patient care while alleviating the burden of misconceptions in practice. We provide an in-depth and interactive investigation of physiological concepts as a foundation for understanding body fluid dynamics. Finally, we offer a new classification of symptoms of heart failure...
March 2024: Iranian Journal of Kidney Diseases
#7
David M Sparks, Edwin Rajeev, Alberto Canestrelli, James C Liao
UNLABELLED: Fish in the wild often contend with complex flows that are produced by natural and artificial structures. Research into fish interactions with turbulence often investigates metrics such as turbulence kinetic energy (TKE) or fish positional location, with less attention paid to the specific interactions between vortex organization and body swimming kinematics. Here we compare the swimming kinematics of rainbow trout ( Oncorhynchus mykiss ) holding station in flows produced by two different 3 x 5 cylinder arrays...
April 19, 2024: bioRxiv
#8
JOURNAL ARTICLE
Marina Ohne, Yoshitaka Watanabe, Chisato Oyake, Yuta Onuki, Tsuneki Watanabe, Hirokazu Ikeda
Anorexia nervosa can lead to kidney complications. Few studies reported kidney biopsy results in young adults, most of whom had chronic anorexia nervosa, and kidney biopsy findings in pediatric patients with early-phase anorexia nervosa are rarely reported. A 14-year-old girl who lost weight due to excessive exercise and reduced diet was admitted for kidney dysfunction. She was 147 cm tall and weighed 32.9 kg, with a body mass index of 15.2 kg/m2 . She was 39 kg about a year earlier. Her heart rate and blood pressure were 30-40 beats/min and 108/68 mmHg, respectively...
April 24, 2024: CEN Case Reports
#9
JOURNAL ARTICLE
Kai Bin Lim, Shen-Yang Lim, Jia Wei Hor, Heamah Krishnan, Firdaus Mortadza, Jia Lun Lim, Karuthan Chinna, Nor Izzati Saedon, Ai Huey Tan
BACKGROUND: Screening for orthostatic hypotension (OH) is integral in Parkinson's disease (PD) management, yet evidence-based guidelines on best practice methods for diagnosing OH in PD are lacking. METHODS: We investigated the frequency and correlates of OH, symptomatic OH, and neurogenic OH, in a large consecutively recruited PD cohort (n = 318), and compared the diagnostic performance of the sit-to-stand vs. the supine-to-stand blood pressure (BP) test...
April 22, 2024: Parkinsonism & related Disorders
#10
JOURNAL ARTICLE
Fatma Uysal, Saliha Ayşenur Çam Özünlü, Ibraheem Akram Omar Alhirmizi, Seyfullah Oktay Arslan, Ebru Annaç, Ali Parlar, Oğuzhan Yıldız
Objectives: The aim of this study was to investigate the role of cannabinoid (CB1) receptors on airway inflammation and hypersensitivity in allergic asthma and the potential interactions with TRPV1 channels. Materials and Methods: BALB/c mice were sensitized and provoked with ovalbumin to create a model of allergic asthma. CB1 selective agonist arachidonoyl 2'-chloroethylamide (ACEA) was administered intraperitoneally at doses of 0.5, 3, and 5 mg/kg. Receptor antagonism studies were performed utilizing selective CB1 antagonists AM251 at a dose of 3 mg/kg...
April 24, 2024: Cannabis and Cannabinoid Research
#11
JOURNAL ARTICLE
Golam K Mia, Emma Hawley, Mustapha Yusuf, Glenn Dorsam, Kendall C Swanson
This study evaluated if vasoactive intestinal polypeptide (VIP) influences growth performance, nutrient digestibility, nitrogen balance, and digestive enzyme activity. Sixteen wether lambs (69.6 ± 1.9 kg) were housed in individual pens, adapted to a corn grain-based diet, and randomly assigned to 2 treatment groups. Lambs were injected intraperitoneally every other day for 28 days with saline (0.9% NaCl) containing no VIP (n = 8; control) or containing VIP (n = 8; 1.3 nmol/kg BW). All lambs were transferred to individual metabolic crates for the final seven days of the experiment to measure nitrogen balance and nutrient digestibility...
April 24, 2024: Journal of Animal Science
#12
REVIEW
D L McCarter, C Morgan, L Bray, L Tume
UNLABELLED: Poor growth and nutrition management in the neonatal period can have a negative impact upon both the short- and long-term outcomes for the infant. Improvements in bioelectrical impedance technology and accompanying licencing agreements now make this enhanced device available for use in infants as small as 23 weeks gestational age. An exploration of this technology and its use is now timely. The aim of the scoping review was to answer the following question: in preterm and sick term infants in the neonatal intensive care unit, how is bioelectrical impedance being utilized, in what situations, and when? The scoping review was conducted using Arksey and O'Malley's (Int J Soc Res Methodol 8(1):19-32, 2005) framework...
April 24, 2024: European Journal of Pediatrics
#13
JOURNAL ARTICLE
Ruchita Attal, Vijayshri Deotale
BACKGROUND: COVID-19 pneumonia with an unusual outbreak is considered a new, global public health threat. Microbiological characterization of co-infections in patients with COVID-19 is important, and antimicrobial use is high. We aimed to describe microbiologically confirmed co-infections and the antimicrobial resistance of the causative pathogens. METHOD: From January to December 2020, we tested 1,301 patients who were COVID-19 positive. We received clinical samples (blood, respiratory and sterile body fluids) of COVID-19 patients who were suspected to have bacterial co-infections...
2024: GMS Hygiene and Infection Control
#14
Shailesh Bhanudas Meshram, Hiral Gulab Ramnani, Spandana Chaudhury
Schistosomiasis is a parasitic disease caused by trematodes (body flukes), affecting millions worldwide. However, its pulmonary manifestations are rare. We report a rare case of a 51-year-old People Living with HIV male, managed in a tertiary care hospital in west India in May 2023, vegetable vendor who was admitted with complaints of dysphagia, odynophagia, fever and chest pain for 3 days, cough and breathlessness for 1 month. Chest x-ray and CT scan were suggestive of hypodense fluid collection with rim enhancement along right lateral and posterior aspect of thoracic esophagus...
2024: Iranian Journal of Parasitology
#15
JOURNAL ARTICLE
Zhenxing Zhang, Shan Wang, Kelong Tao, Guolin Zhang, Danling Guo, Yu Zhang, Guangen Xu
BACKGROUND: Gastric intramural hematoma is a rare disease. Here we report a case of spontaneous isolated gastric intramural hematoma combined with spontaneous superior mesenteric artery intermural hematoma. CASE PRESENTATION: A 75-years-old man was admitted to our department with complaints of abdominal pain. He underwent a whole abdominal computed tomography (CT) scan in the emergency department, which showed extensive thickening of the gastric wall in the gastric body and sinus region with enlarged surrounding lymph nodes, localized thickening of the intestinal wall in the transverse colon, localized indistinct demarcation between the stomach and transverse colon, and a small amount of fluid accumulation in the abdominal cavity...
April 23, 2024: BMC Geriatrics
#16
REVIEW
Caiyan Yin, Jianwei Yu, Gaohua Liu, Jun He, Peng Wu
Cervical cancer is a prominent cause of cancer-related mortality among women, with recent attention directed toward exploring the involvement of circular RNAs (circRNAs) in this particular cancer. CircRNAs, characterized by a covalently closed loop structure, belong to a class of single-stranded non-coding RNA (ncRNA) molecules that play crucial roles in cancer development and progression through diverse mechanisms. The abnormal expression of circRNAs in vivo is significantly associated with the development of cervical cancer...
April 17, 2024: Pathology, Research and Practice
#17
JOURNAL ARTICLE
Xiao Zhang, Xin-Yi Jiang, Ji-Ying Cai, Shuai Chen, Yong-Liang Yu, Jian-Hua Wang
Microplastics (MPs) can act as carriers of environmental arsenic species into the stomach with food and release arsenic species during digestion, which threatens human health. Herein, an integrated dynamic stomach model (DSM)-capillary electrophoresis-inductively coupled plasma mass spectrometry (CE-ICPMS) is developed for online monitoring of the release and transformation behaviors of arsenic species loaded on MPs (As-MPs) in the simulated human stomach. The 3D-printed DSM with a soft stomach chamber enables the behaviors of gastric peristalsis, gastric and salivary fluid addition, pH adjustment, and gastric emptying (GE) to be controlled by a self-written program after oral ingestion of food with As-MPs...
April 23, 2024: Analytical Chemistry
#18
JOURNAL ARTICLE
Hushnaara Hadem, Arijit Mitra, Atul Kumar Ojha, Ragavi Rajasekaran, Bangmaya Satpathy, Debasish Das, Sayan Mukherjee, Santanu Dhara, Siddhartha Das, Karabi Das
This study presents a facile fabrication of 58S bioactive glass (BG)-polymer composite coatings on a 316L stainless steel (SS) substrate using the electrophoretic deposition technique. The suspension characteristics and deposition kinetics of BG, along with three different polymers, namely ethylcellulose (EC), poly(acrylic acid) (PAA), and polyvinylpyrrolidone (PVP), have been utilized to fabricate the coatings. Among all coatings, 58S BG and EC polymers are selected as the final composite coating (EC6) owing to their homogeneity and good adhesion...
April 23, 2024: ACS Applied Bio Materials
#19
JOURNAL ARTICLE
Nantia Leonidou, Lisa Ostyn, Tom Coenye, Aurélie Crabbé, Andreas Dräger
Cystic fibrosis (CF), an inherited genetic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator gene, results in sticky and thick mucosal fluids. This environment facilitates the colonization of various microorganisms, some of which can cause acute and chronic lung infections, while others may positively impact the disease. Rothia mucilaginosa , an oral commensal, is relatively abundant in the lungs of CF patients. Recent studies have unveiled its anti-inflammatory properties using in vitro three-dimensional lung epithelial cell cultures and in vivo mouse models relevant to chronic lung diseases...
April 23, 2024: Microbiology Spectrum
#20
JOURNAL ARTICLE
Katerina Deike, Andreas Decker, Paul Scheyhing, Julia Harten, Nadine Zimmermann, Daniel Paech, Oliver Peters, Silka D Freiesleben, Luisa-Sophie Schneider, Lukas Preis, Josef Priller, Eike Spruth, Slawek Altenstein, Andrea Lohse, Klaus Fliessbach, Okka Kimmich, Jens Wiltfang, Claudia Bartels, Niels Hansen, Frank Jessen, Ayda Rostamzadeh, Emrah Düzel, Wenzel Glanz, Enise I Incesoy, Michaela Butryn, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Goerss, Christoph Laske, Matthias H Munk, Annika Spottke, Nina Roy, Michael Wagner, Sandra Roeske, Michael T Heneka, Frederic Brosseron, Alfredo Ramirez, Laura Dobisch, Steffen Wolfsgruber, Luca Kleineidam, Renat Yakupov, Melina Stark, Matthias C Schmid, Moritz Berger, Stefan Hetzer, Peter Dechent, Klaus Scheffler, Gabor C Petzold, Anja Schneider, Alexander Effland, Alexander Radbruch
OBJECTIVES: Impaired perivascular clearance has been suggested as a contributing factor to the pathogenesis of Alzheimer disease (AD). However, it remains unresolved when the anatomy of the perivascular space (PVS) is altered during AD progression. Therefore, this study investigates the association between PVS volume and AD progression in cognitively unimpaired (CU) individuals, both with and without subjective cognitive decline (SCD), and in those clinically diagnosed with mild cognitive impairment (MCI) or mild AD...
April 23, 2024: Investigative Radiology
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