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JOURNAL ARTICLE
Quanyi Chen, Xiaofei Hu, Ting Zhang, Qianying Ruan, Hongye Wu
BACKGROUND: Parkinson disease (PD) is a common neurodegenerative disorder, but its pathogenesis is still not entirely understood. While some trace elements, such as selenium, iron, and copper, are considered pivotal in PD onset due to their role in oxidative stress, the association between selenium concentrations and PD susceptibility remains ambiguous. METHODS: A systematic review and meta-analysis was conducted in adherence to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and framed by the Patient, Intervention, Comparison, Outcome paradigm...
April 26, 2024: Medicine (Baltimore)
#2
COMPARATIVE STUDY
R S M Mensink, W Paans, M H Renes, W Dieperink, F Blokzijl
BACKGROUND: The fluid balance is a critical parameter in intensive care units (ICU) as it provides information about the patient's volume status. However, the accuracy of fluid balance measurements is often compromised due to the complexity and repetition of actions involved. Additionally, the fluid balance could be recalculated for insensible fluid loss. Weighing is an alternative method to estimate the patient's volume status. Built-in scales in beds make patient weighing easier and less time-consuming, allowing clinicians to intervene more quickly on existing treatments...
2024: PloS One
#3
JOURNAL ARTICLE
Igal Rosenstein, Anna Nordin, Hemin Sabir, Clas Malmeström, Kaj Blennow, Markus Axelsson, Lenka Novakova
OBJECTIVE: Insidious disability worsening is a common feature in relapsing-remitting multiple sclerosis (RRMS). Many patients experience progression independent of relapse activity (PIRA) despite being treated with high efficacy disease-modifying therapies. We prospectively investigated associations of body-fluid and imaging biomarkers with PIRA. METHODS: Patients with early RRMS (n = 104) were prospectively included and followed up for 60 months...
April 26, 2024: Journal of Neurology
#4
JOURNAL ARTICLE
Elisabeth Eckert, Thomas Jäger, Julia Hiller, Edgar Leibold, Michael Bader, Thomas Göen
2-Phenoxyethanol (PhE) is an aromatic glycol ether and is used in a variety of functions and applications, e.g., as preservative in pharmaceuticals, cosmetic and personal care products, as biocide in disinfectants (e.g. human hygiene), or as a solvent in formulations (e.g. coatings, functional fluids). Despite its widespread use, little is yet known on its biotransformation and toxicokinetics in humans. Therefore, a pilot study was conducted with oral administration of PhE (5 mg/kg body weight) to five volunteers...
April 26, 2024: Archives of Toxicology
#5
JOURNAL ARTICLE
Fabian Martinez-Pallares, Manuel Herrera, Olivia A Graeve
We present a luminescence study investigating the dissolution of rare-earth-doped hydroxyapatite scaffolds in simulated body fluid (SBF), aiming to assess the luminescence stability of Tb-, Ce-, and Eu-doped scaffolds over time. Our findings reveal a consistent decrease in luminescence emission intensity across all samples over a four-week period in which the scaffolds were immersed in the SBF. In addition, energy-dispersive spectroscopy confirms a decrease in rare-earth ion concentration in the scaffolds with respect to time, whereas fluorescence spectroscopy shows the presence of rare-earth ions in the SBF, indicating the partial dissolution of the scaffolds over time...
April 26, 2024: ACS Applied Bio Materials
#6
JOURNAL ARTICLE
Yang Chen, Jinying Shi, Huamai Qiu, Lijun You, Panqi Xu, Rui Rao, Minqian Wu, Ruohan Jia
Three Laminaria japonica polysaccharides (LJPs) extracted via water extraction (LJP-W), acid extraction (LJP-A), and enzymatic extraction (LJP-E) were used as raw materials to be cross-linked with chitosan and polyvinyl alcohol to prepare hydrogels. Compared with conventional hydrogel systems, all three types of LJP-based polysaccharide hydrogels exhibited better swelling properties (14 times their original weight) and the absorption ability of simulated body fluid (first 2 h: 6-10%). They also demonstrated better rigidity and mechanical strength...
April 20, 2024: Marine Drugs
#7
JOURNAL ARTICLE
Ahmed Salama, Emad Tolba, Ahmed K Saleh, Iriczalli Cruz-Maya, Marco A Alvarez-Perez, Vincenzo Guarino
In recent years, polyelectrolytes have been successfully used as an alternative to non-collagenous proteins to promote interfibrillar biomineralization, to reproduce the spatial intercalation of mineral phases among collagen fibrils, and to design bioinspired scaffolds for hard tissue regeneration. Herein, hybrid nanofibers were fabricated via electrospinning, by using a mixture of Poly ɛ-caprolactone (PCL) and cationic cellulose derivatives, i.e., cellulose-bearing imidazolium tosylate (CIMD). The obtained fibers were self-assembled with Sodium Alginate (SA) by polyelectrolyte interactions with CIMD onto the fiber surface and, then, treated with simulated body fluid (SBF) to promote the precipitation of calcium phosphate (CaP) deposits...
April 22, 2024: Biomimetics
#8
JOURNAL ARTICLE
Ayodeji T Bode-Oke, Alec Menzer, Haibo Dong
Cicadas are heavy fliers well known for their life cycles and sound production; however, their flight capabilities have not been extensively investigated. Here, we show for the first time that cicadas appropriate backward flight for additional maneuverability. We studied this flight mode using computational fluid dynamics (CFD) simulations based on three-dimensional reconstructions of high-speed videos captured in a laboratory. Backward flight was characterized by steep body angles, high angles of attack, and high wing upstroke velocities...
April 14, 2024: Biomimetics
#9
JOURNAL ARTICLE
Imen Hammami, Manuel Pedro Fernandes Graça, Sílvia Rodrigues Gavinho, Suresh Kumar Jakka, João Paulo Borges, Jorge Carvalho Silva, Luís Cadillon Costa
In recent decades, the requirements for implantable medical devices have increased, but the risks of implant rejection still exist. These issues are primarily associated with poor osseointegration, leading to biofilm formation on the implant surface. This study focuses on addressing these issues by developing a biomaterial for implant coatings. 45S5 bioglass® has been widely used in tissue engineering due to its ability to form a hydroxyapatite layer, ensuring a strong bond between the hard tissue and the bioglass...
April 2, 2024: Biomimetics
#10
REVIEW
Zhiwei Cui, Ye Wang, Jaap M J den Toonder
Cilia are slender, hair-like cell protrusions that are present ubiquitously in the natural world. They perform essential functions, such as generating fluid flow, propulsion, and feeding, in organisms ranging from protozoa to the human body. The coordinated beating of cilia, which results in wavelike motions known as metachrony, has fascinated researchers for decades for its role in functions such as flow generation and mucus transport. Inspired by nature, researchers have explored diverse materials for the fabrication of artificial cilia and developed several methods to mimic the metachronal motion observed in their biological counterparts...
March 27, 2024: Biomimetics
#11
JOURNAL ARTICLE
Sakae Konno, Hiroyuki Kudo
A lactic acid (LA) monitoring system aimed at sweat monitoring was fabricated and tested. The sweat LA monitoring system uses a continuous flow of phosphate buffer saline, instead of chambers or cells, for collecting and storing sweat fluid excreted at the skin surface. To facilitate the use of the sweat LA monitoring system by subjects when exercising, the fluid control system, including the sweat sampling device, was designed to be unaffected by body movements or muscle deformation. An advantage of our system is that the skin surface condition is constantly refreshed by continuous flow...
April 10, 2024: Biosensors
#12
JOURNAL ARTICLE
Cristina Potrich, Gianluca Palmara, Francesca Frascella, Lucio Pancheri, Lorenzo Lunelli
The identification and quantification of biomarkers with innovative technologies is an urgent need for the precise diagnosis and follow up of human diseases. Body fluids offer a variety of informative biomarkers, which are traditionally measured with time-consuming and expensive methods. In this context, lateral flow tests (LFTs) represent a rapid and low-cost technology with a sensitivity that is potentially improvable by chemiluminescence biosensing. Here, an LFT based on gold nanoparticles functionalized with antibodies labeled with the enzyme horseradish peroxidase is combined with a lensless biosensor...
April 9, 2024: Biosensors
#13
JOURNAL ARTICLE
Encheng Sun, Zhenqi Gu, Haoran Li, Xiao Liu, Yuan Li, Fei Xiao
The exploration into nanomaterial-based nonenzymatic biosensors with superb performance in terms of good sensitivity and anti-interference ability in disease marker monitoring has always attained undoubted priority in sensing systems. In this work, we report the design and synthesis of a highly active nanocatalyst, i.e., palladium and platinum nanoparticles (Pt&Pd-NPs) decorated ultrathin nanoporous gold (NPG) film, which is modified on a homemade graphene paper (GP) to develop a high-performance freestanding and flexible nanohybrid electrode...
April 3, 2024: Biosensors
#14
JOURNAL ARTICLE
Johannes Levin, Simone Baiardi, Corinne Quadalti, Marcello Rossi, Angela Mammana, Jonathan Vöglein, Alexander Bernhardt, Richard J Perrin, Mathias Jucker, Oliver Preische, Anna Hofmann, Günter U Höglinger, Nigel J Cairns, Erin E Franklin, Patricio Chrem, Carlos Cruchaga, Sarah B Berman, Jasmeer P Chhatwal, Alisha Daniels, Gregory S Day, Natalie S Ryan, Alison M Goate, Brian A Gordon, Edward D Huey, Laura Ibanez, Celeste M Karch, Jae-Hong Lee, Jorge Llibre-Guerra, Francisco Lopera, Colin L Masters, John C Morris, James M Noble, Alan E Renton, Jee Hoon Roh, Matthew P Frosch, C Dirk Keene, Catriona McLean, Raquel Sanchez-Valle, Peter R Schofield, Charlene Supnet-Bell, Chengjie Xiong, Armin Giese, Oskar Hansson, Randall J Bateman, Eric McDade, Piero Parchi
INTRODUCTION: Amyloid beta and tau pathology are the hallmarks of sporadic Alzheimer's disease (AD) and autosomal dominant AD (ADAD). However, Lewy body pathology (LBP) is found in ≈ 50% of AD and ADAD brains. METHODS: Using an α-synuclein seed amplification assay (SAA) in cerebrospinal fluid (CSF) from asymptomatic (n = 26) and symptomatic (n = 27) ADAD mutation carriers, including 12 with known neuropathology, we investigated the timing of occurrence and prevalence of SAA positive reactivity in ADAD in vivo...
April 26, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#15
JOURNAL ARTICLE
Kanber Kara, Sena Yilmaz, Kamil Emre Gerçekaslan, Serkan Özkaya
Plantago species, which is known to adapt to different climatic conditions, drought, temperature and different soil types. The aim of this study was to compare the effects of P. lanceolata herbage on fattening performance, rumen variables, digestibility, meat quality, meat nutrients and meat textural variables in lambs with the values of Italian ryegrass and sainfoin herbages. The lambs were fed total mix ration (TMR) with concentrated feed (about 30%) plus forage (about 70%) (P. lanceolata, PLA, Italian ryegrass (Lolium multiflorum); IRY or sainfoin (Onobrychis viciifolia) herbages, SAI)...
April 25, 2024: Journal of Animal Physiology and Animal Nutrition
#16
JOURNAL ARTICLE
Johannes Rich, Sarah Hubler, Beatriz Vidondo, Mathieu Raillard, Daniela Schweizer
BACKGROUND: Changes in the brain can affect the flow velocity of cerebrospinal fluid (CSF). In humans, the flow velocity of CSF is not only altered by disease but also by age and sex. Such influences are not known in dogs. HYPOTHESIS: Peak flow velocity of CSF in dogs is associated with body weight, age, and sex. ANIMALS: Peak flow velocity of CSF was measured in 32 client-owned dogs of different breeds, age, and sex. METHODS: Peak flow velocity of CSF was determined by phase-contrast magnetic resonance imaging (PC-MRI) at the mesencephalic aqueduct, foramen magnum (FM), and second cervical vertebral body (C2)...
April 25, 2024: Journal of Veterinary Internal Medicine
#17
RANDOMIZED CONTROLLED TRIAL
Rong Luan, Manqiao Wang, Yi Gong, Boshi Liu, Xinyuan Huang, Jie Wang, Shuo Sun, Jinzhi Zhao, Xiteng Chen, Qianhui Yang, Juping Liu, Yan Shao, Xiaorong Li
BACKGROUND: We aimed to investigate the anatomical features of optical coherence tomography (OCT) and vitreous cytokine levels as predictors of outcomes of combined phacovitrectomy with intravitreal dexamethasone (DEX) implants for idiopathic epiretinal membrane (iERM) treatment. METHODS: A prospective, single-masked, randomized, controlled clinical trial included 48 eyes. They were randomly assigned in a 1:1 ratio to undergo the DEX group (combined phacovitrectomy with ERM peeling and Ozurdex implantation) and control group (phacovitrectomy only)...
April 25, 2024: BMC Ophthalmology
#18
JOURNAL ARTICLE
Cláudio Rodrigues Rezende Costa, Rym Chalgoumi, Amina Baker, Clément Guillou, Paulo Marcio Yamaguti, Victor Simancas Escorcia, Lilia Abbad, Bruna Rabelo Amorin, Caroline Lourenço de Lima, Vidjea Cannaya, Mourad Benassarou, Ariane Berdal, Christos Chatziantoniou, Olivier Cases, Pascal Cosette, Renata Kozyraki, Ana Carolina Acevedo
Raine syndrome (RNS) is a rare autosomal recessive osteosclerotic dysplasia. RNS is caused by loss-of-function disease-causative variants of the FAM20C gene that encodes a kinase that phosphorylates most of the secreted proteins found in the body fluids and extracellular matrix. The most common RNS clinical features are generalized osteosclerosis, facial dysmorphism, intracerebral calcifications and respiratory defects. In non-lethal RNS forms, oral traits include a well-studied hypoplastic amelogenesis imperfecta (AI) and a much less characterized gingival phenotype...
April 25, 2024: Scientific Reports
#19
JOURNAL ARTICLE
Lu Liu, Shao-Dan Cheng, Yang Cheng, Si-Chen Peng, Cheng Ge, Shi-Hui Wang
OBJECTIVE: To evaluate the rabbit modle of frozen shoulder induced by persistent strain injuries and ice compression. METHODS: Twelve clean, healthy male New Zealand rabbits with a mass of (2 500±500) g were selected and randomly divided into a blank group and a control group with 6 rabbits in each group. In the control group, the rabbits were modeled with persistent strain injuries and ice compression, the general conditions of the rabbits and the active and passive activities of the shoulder joint were observed and their body weights were recorded...
April 25, 2024: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
#20
JOURNAL ARTICLE
Jan Fiala, Dina Schuster, Simon Ollivier, Stuart Pengelley, Markus Lubeck, Florian Busch, Andris Jankevics, Oliver Raether, Jean-Francois Greisch, Albert J R Heck
Endogenous antibodies, or immunoglobulins (Igs), abundantly present in body fluids, represent some of the most challenging samples to analyze, largely due to the immense variability in their sequences and concentrations. It has been estimated that our body can produce billions of different Ig proteins with different isotypes, making their individual analysis seemingly impossible. However, recent advances in protein-centric proteomics using LC-MS coupled to Orbitrap mass analyzers to profile intact Fab fragments formed by selective cleavage at the IgG-hinge revealed that IgG repertoires may be less diverse, albeit unique for each donor...
April 25, 2024: Journal of the American Society for Mass Spectrometry
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