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Pancrease MR

Wanling Ma, Na Li, Weiwei Zhao, Jing Ren, Mengqi Wei, Yong Yang, Yingmei Wang, Xin Fu, Zhuoli Zhang, Andrew C Larson, Yi Huan
OBJECTIVE: To clarify diffusion and perfusion abnormalities and evaluate correlation between apparent diffusion coefficient (ADC), MR perfusion and histopathologic parameters of pancreatic cancer (PC). METHODS: Eighteen patients with PC underwent diffusion-weighted imaging and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Parameters of DCE-MRI and ADC of cancer and non-cancerous tissue were compared. Correlation between the rate constant that represents transfer of contrast agent from the arterial blood into the extravascular extracellular space (K, volume of the extravascular extracellular space per unit volume of tissue (Ve), and ADC of PC and histopathologic parameters were analyzed...
September 2016: Journal of Computer Assisted Tomography
H An, Y Shi, Q Guo, Y Liu
AIM: To determine the repeatability of three-dimensional echo planar imaging magnetic resonance (MR) elastography (3D EPI MRE) for assessing pancreatic stiffness in healthy volunteers, patients with chronic pancreatitis, and patients with pancreatic ductal adenocarcinoma (PDAC). MATERIALS AND METHODS: 3D EPI MRE was used to assess pancreatic stiffness in five healthy volunteers, and five and three patients with histopathologically confirmed chronic pancreatitis and PDAC, respectively...
October 2016: Clinical Radiology
G Allegretti, P Saccomandi, F Giurazza, M A Caponero, G Frauenfelder, F M Di Matteo, B Beomonte Zobel, S Silvestri, E Schena
Laser Ablation (LA) is a minimally-invasive procedure for tumor treatment. LA outcomes depend on the heat distribution inside tissues and require accurate temperature measurement during the procedure. Magnetic resonance imaging (MRI) allows a non-invasive and three-dimensional thermometry of the organ undergoing LA. In this study, the temperature distribution within two swine pancreases and three swine livers undergoing LA (Nd:YAG, power: 2 W, treatment time: 4 min) was monitored by a 1.5-T MR scanner, utilizing two T1-weighted sequences (IRTF and SRTF)...
July 2015: Medical Engineering & Physics
Dávid Z Balla, Sven Gottschalk, G Shajan, Sandra Ueberberg, Stephan Schneider, Matthias Hardtke-Wolenski, Elmar Jaeckel, Verena Hoerr, Cornelius Faber, Klaus Scheffler, Rolf Pohmann, Jörn Engelmann
The purpose of this study was to investigate the potential of a novel targeted contrast agent (CA) for the in vivo visualization of single native pancreatic islets, the sites of insulin production, in the pancreas of mice using magnetic resonance imaging (MRI). The CA for intravenous administration was composed of the β-cell-specific single-chain antibody fragment, SCA B1, and ferromagnetic carbon-coated cobalt nanoparticles. MRI experiments were performed at 7, 9.4 and 16.4 T in excised organs (pancreas, liver, kidney, spleen), at 7 T in mice fixed in formalin and at 9...
November 2013: Contrast Media & Molecular Imaging
Xiaohong Ma, Xinming Zhao, Han Ouyang, Fei Sun, Hongmei Zhang, Chunwu Zhou
BACKGROUND: As their prognosis and management are different, differentiation of mass-forming focal pancreatitis (FP) from pancreatic adenocarcinoma (PC) is important. However, the similar clinical presentations and imaging features of these conditions, along with inconclusive biopsy results can make such differentiation difficult. PURPOSE: To determine whether apparent diffusion coefficient (ADC) histogram analysis can discriminate between a normal pancreas, FP, and PC...
September 2014: Acta Radiologica
Shi-Fan Chen, Atsuko Kasajima, Samaneh Yazdani, Monica S M Chan, Lin Wang, Yang-Yang He, Hong-Wen Gao, Hironobu Sasano
α-Thalassemia/mental retardation syndrome X-linked protein (ATRX) and death domain-associated protein (DAXX) genes are tumor suppressors whose mutations have been identified in sporadic pancreatic neuroendocrine tumors as well as in patients with MEN1. However, it is unknown whether ATRX and DAXX alterations are specific for pancreatic neuroendocrine tumor. In addition, the association of ATRX/DAXX protein loss with tumor cell proliferation has not been examined. We, therefore, immunostained ATRX and DAXX in 10 gastric, 15 duodenal, 20 rectal, 70 pancreatic, and 22 pulmonary neuroendocrine tumors with 15 nonneoplastic pancreases and 27 pancreatic adenocarcinomas to elucidate the site-specific roles of ATRX/DAXX abnormalities...
October 2013: Human Pathology
Kyung Mi Jang, Seong Hyun Kim, Hyun Jeong Park, Sanghyeok Lim, Tae Wook Kang, Soon Jin Lee, Dongil Choi
BACKGROUND: Ectopic pancreas can frequently be mistaken for other submucosal masses. Ectopic pancreas may follow the signal intensity of mother pancreas on various magnetic resonance (MR) sequences, which might be helpful for differentiation between ectopic pancreas and other submucosal tumors in upper gastrointestinal (UGI) tract. PURPOSE: To evaluate the value of MR imaging (MRI) in differentiating ectopic pancreases from submucosal tumors in UGI tract. MATERIAL AND METHODS: Fifteen patients with ectopic pancreas and 26 patients with UGI submucosal tumors were included...
December 2013: Acta Radiologica
Abdeslem El Idrissi, Xin Yan, Francoise Sidime, William L'Amoreaux
BACKGROUND: The fragile X mouse model shows an increase in seizure susceptibility, indicating an involvement of the GABAergic system via an alteration in cellular excitability. In the brain, we have previously described a reduction in GABAA receptor expression as a likely basis for this susceptibility. In the brains of fragile X mice, this reduction in receptor expression culminates with a concomitant increase in the expression of glutamic acid decarboxylase (GAD), the enzyme responsible for GABA synthesis...
2010: Journal of Biomedical Science
Liliana Gabrielli, Maria Paola Bonasoni, Tiziana Lazzarotto, Stefania Lega, Donatella Santini, Maria Pia Foschini, Brunella Guerra, Federica Baccolini, Giulia Piccirilli, Angela Chiereghin, Evangelia Petrisli, Giorgio Gardini, Marcello Lanari, Maria Paola Landini
BACKGROUND: Congenital cytomegalovirus (CMV) infection is a major cause of central nervous system damage leading to sensorineural hearing loss, mental retardation and cerebral palsy. OBJECTIVES: Identify the type of organ involvement and understand the histopathogenesis of damage in foetuses of women with a CMV-highly positive amniotic fluid. STUDY DESIGN: 34 foetuses with congenital CMV infection documented by prenatal diagnosis were studied...
December 2009: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Soon Gu Cho, Don Haeng Lee, Keon Young Lee, Hoon Ji, Kyung Hee Lee, Pablo R Ros, Chang Hae Suh
OBJECTIVE: To determine the differences between the in vivo proton magnetic resonance spectroscopy (H-MRS) features of chronic focal pancreatitis and pancreatic carcinoma and to evaluate the possibility of discriminating chronic focal pancreatitis from pancreatic carcinoma by analysis of in vivo H-MR spectra. METHODS: The H-MR spectra from 36 human pancreases were evaluated in vivo. This series included 15 cases of chronic focal pancreatitis and 21 cases of pancreatic carcinoma...
March 2005: Journal of Computer Assisted Tomography
Wenzhen Zhu, Liming Xia, Jianpin Qi, Chengyuan Wang, Daoyu Hu, Junwu Hu, Dingyi Feng
OBJECTIVE: To evaluate the value of magnetic resonance imaging (MRI) and three dimensional (3D) contrast magnetic resonance angiography (MRA) in the diagnosis of complications of simultaneous pancreas-kidney transplantation (SPKT), as confirmed by biopsy and digital subtraction angiography (DSA). METHODS: Five MR examinations of five patients were performed within 28 days to 2 years after surgery on GE 1.5T MR system. Imaging techniques included axial and sagittal chemical fat-suppressed T1-weighted image (T1WI) and T2-weighted image (T2WI), additional contrast axial or saggital chemical fat-suppressed T1WI were obtained after 3D contrast MRA for calculating the mean percentage of the parenchymal enhancement (MPPE) of the pancreas and kidney...
December 2002: Chinese Medical Journal
M J Varas Lorenzo, J R Armengol Miró, J Boix Valverde, M D Maluenda Colomer, J M Pou Fernández
UNLABELLED: Around 30% of the gastroenteropancreatic endocrine tumors (GPET) cannot be preoperatively identified by the common diagnostic imaging techniques. The aim of this retrospective study was to present our experience in the diagnosis and localization of GPET by endoscopic ultrasonography (EUS) performed prior to surgery and compare this with a review of the literature. PATIENTS AND METHODS: Twenty patients suspected of having specific hormonal syndromes were correlatively explored with US, CT, MR, angiography, octreoscan and radial EUS with Olympus GFUM3/EUM3 and GF-UM20/EUM 20 and 30...
May 1999: Gastroenterología y Hepatología
A K Tung, K P Siu
A large-molecular-weight proinsulin-immunoreactive protein fraction was obtained from an extract of fetal bovine pancreases by gel filtration in 6 M guanidine-1 M acetic acid. Concanavalin A-Sepharose-affinity column chromatography of the large-molecular-weight fraction yielded a discrete alpha-methyl-mannoside-displaceable immunoreactive peak that also displayed N-acetylglucosamine-specific binding to wheat germ lectin-Sepharose. Chemically tritiated and radioiodinated lectin-reactive proteins interacted specifically with antibodies to insulin and bovine proinsulin...
April 1987: Diabetes
T Krahe, W Dölken, K Lackner, M Houselog, W Habscheid, W Clauss
150 MR examinations of the upper abdomen were carried out after the oral administration of 5 ml/kg body weight of a gadolinium DTPA formulation (1.0 mmol/l, 15 g/l mannitol), with reference to the delineation of the pancrease, the liver and intra-abdominal fat. For comparison, 100 MR examinations without oral opacification of the G.I. tract were evaluated. Contrast administration resulted in a signal-intensive demonstration of the G.I. tract for all measurement sequences. The intraluminal contrast improved the distinction between normal and abnormal structures...
August 1990: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
S M Elizarov, G K Kovaleva
Incubation of tryptophanyl-tRNA synthetase from bovine pancrease with [gamma-32P]ATP of [gamma-32P]GTP and casein kinase II from rabbit liver leads to the incorporation of labeled phosphate into serine residues of synthetase polypeptide. The maximal level of 32P incorporation into synthetase polypeptide (Mr = 60 kDa) 0.15 moles of 32P per 1 mole of polypeptide was observed. Electrophoretic analysis according to O'Farrell showed that kinase phosphorylates exclusively the most acidic polypeptides (pI 4.9) of the synthetase preparation...
November 1990: Molekuliarnaia Biologiia
T Kushnir, O Kaplan, N Askenasy, G Navon
Multinuclear MR was applied to the study of experimental acute pancreatitis. A continuous increase, up to 700%, of total, NMR visible, sodium content was detected during the development of the disease through the edematous stage to necrosis. The effect of the elevation of sodium content is amplified by an increased 23Na NMR visibility during the disease. Interstitial and total water volume of pancreases were estimated using the distribution of Co(CN)3-(6) and D2O, by 59Co and 2H NMR, respectively. In healthy pancreases the interstitial compartment was found to comprise 35% of the tissue volume...
August 1991: NMR in Biomedicine
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