Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Jeane de Souza Nogueira, Thamires Rodrigues Gomes, Danielle Angst Secco, Inez Silva de Almeida, Alessandra Saldanha Matheus Fernandes da Costa, Roberta Arnoldi Cobas, Gilson Costados Santos, Marília Brito Gomes, Luís Cristóvão Pôrto
To control immune responses, regulatory CD4+ CD25+ Foxp3+ T cells (Treg) maintain their wide and diverse repertoire through continuous arrival of recent thymic emigrants (RTE). However, during puberty, the activity of RTE starts to decline as a natural process of thymic involution, introducing consequences, not completely described, to the repertoire. Type 1 diabetes (T1D) patients show quantitative and qualitative impairments on the Treg cells. Our aim was to evaluate peripheral Treg and RTE cell frequencies, in T1D patients from two distinct age groups (young and adults) and verify if HLA phenotypes are concomitant associated...
April 9, 2024: Immunology Letters
#2
JOURNAL ARTICLE
Lisa Wu, Florian Kälble, Hanns-Martin Lorenz, Martin Zeier, Matthias Schaier, Andrea Steinborn
Systemic lupus erythematosus (SLE) is a sex biased chronic autoimmune disease affecting predominantly females during reproductive ages. Changes in the ratio of inducible costimulatory molecule (ICOS)+ regulatory (Treg) and non-regulatory responder (Tresp) CD4+ T cells proved to be crucial for the occurrence of high disease activity. Here, we investigated how the differentiation of ICOS+ CD45RA+ CD31+ recent thymic emigrant (RTE) Tresps into CD45RA- CD31- memory Tresps affects the percentages of ICOS+ Tresps within total CD4+ T cells...
March 1, 2024: Clinical and Experimental Medicine
#3
JOURNAL ARTICLE
Sarah-Jolan Bremer, Annika Boxnick, Laura Glau, Daniel Biermann, Simon A Joosse, Friederike Thiele, Elena Billeb, Jonathan May, Manuela Kolster, Romy Hackbusch, Mats Ingmar Fortmann, Rainer Kozlik-Feldmann, Michael Hübler, Eva Tolosa, Jörg Siegmar Sachweh, Anna Gieras
Congenital heart disease (CHD) is the most common birth defect, and up to 50% of infants with CHD require cardiovascular surgery early in life. Current clinical practice often involves thymus resection during cardiac surgery, detrimentally affecting T-cell immunity. However, epidemiological data indicate that CHD patients face an elevated risk for infections and immune-mediated diseases, independent of thymectomy. Hence, we examined whether the cardiac defect impacts thymus function in individuals with CHD...
February 23, 2024: Journal of Clinical Immunology
#4
JOURNAL ARTICLE
Giorgio Costagliola, Annalisa Legitimo, Veronica Bertini, Antonino Maria Quintilio Alberio, Angelo Valetto, Rita Consolini
The clinical expression of 22q11.2 deletion syndrome (22q11.2 DS) is extremely variable, as patients can present with recurrent or severe infections, immune dysregulation, atopic diseases, or extra-immunological manifestations. The immunological background underlying the different disease manifestations is not completely elucidated. The aim of this study was to identify the immunophenotypic peculiarities of 22q11.2 DS patients presenting with different disease expressions. This study included 34 patients with 22q11...
December 8, 2023: Journal of Clinical Medicine
#5
JOURNAL ARTICLE
Sevgi Bilgic Eltan, Ercan Nain, Mehmet Cihangir Catak, Ege Ezen, Asena Pınar Sefer, Nastaran Karimi, Ayca Kiykim, Burcu Kolukisa, Dilek Baser, Alper Bulutoglu, Nurhan Kasap, Melek Yorgun Altunbas, Ezgi Yalcin Gungoren, Yasemin Kendir Demirkol, Seyhan Kutlug, Gonca Hancioglu, Fatih Dilek, Alisan Yildiran, Ahmet Ozen, Elif Karakoc-Aydiner, Batu Erman, Safa Baris
PURPOSE: Immunodeficiency with centromeric instability and facial anomalies (ICF) syndrome is a rare autosomal recessive combined immunodeficiency. The detailed immune responses are not explored widely. We investigated known and novel immune alterations in lymphocyte subpopulations and their association with clinical symptoms in a well-defined ICF cohort. METHODS: We recruited the clinical findings from twelve ICF1 and ICF2 patients. We performed detailed immunological evaluation, including lymphocyte subset analyses, upregulation, and proliferation of T cells...
December 22, 2023: Journal of Clinical Immunology
#6
JOURNAL ARTICLE
Quentin Sabbagh, Sadegheh Haghshenas, Juliette Piard, Chloé Trouvé, Jeanne Amiel, Tania Attié-Bitach, Tugce Balci, Mouna Barat-Houari, Alyce Belonis, Odile Boute, Diana S Brightman, Ange-Line Bruel, Stefano Giuseppe Caraffi, Nicolas Chatron, Corinne Collet, William Dufour, Patrick Edery, Chin-To Fong, Carlo Fusco, Vincent Gatinois, Evan Gouy, Anne-Marie Guerrot, Solveig Heide, Aakash Joshi, Natalya Karp, Boris Keren, Marion Lesieur-Sebellin, Jonathan Levy, Michael A Levy, Claire Lozano, Stanislas Lyonnet, Henri Margot, Pauline Marzin, Haley McConkey, Vincent Michaud, Gaël Nicolas, Mevyn Nizard, Alix Paulet, Francesca Peluso, Vincent Pernin, Laurence Perrin, Christophe Philippe, Chitra Prasad, Madhavi Prasad, Raissa Relator, Marlène Rio, Sophie Rondeau, Valentin Ruault, Nathalie Ruiz-Pallares, Elodie Sanchez, Debbie Shears, Victoria Mok Siu, Arthur Sorlin, Matthew Tedder, Mylène Tharreau, Frédéric Tran Mau-Them, Liselot van der Laan, Julien Van Gils, Alain Verloes, Sandra Whalen, Marjolaine Willems, Kévin Yauy, Roberta Zuntini, Jennifer Kerkhof, Bekim Sadikovic, David Geneviève
PURPOSE: BCL11B-related disorder (BCL11B-RD) arises from rare genetic variants within the BCL11B gene, resulting in a distinctive clinical spectrum encompassing syndromic neurodevelopmental disorder, with or without intellectual disability, associated with facial features and impaired immune function. This study presents an in-depth clinico-biological analysis of 20 newly reported individuals with BCL11B-RD, coupled with a characterization of genome-wide DNA methylation patterns of this genetic condition...
October 17, 2023: Genetics in Medicine: Official Journal of the American College of Medical Genetics
#7
JOURNAL ARTICLE
Hélène M Roux, Amira Marouf, Jacques Dutrieux, Bénédicte Charmeteau-De Muylder, Suzanne Figueiredo-Morgado, Véronique Avettand-Fenoel, Pelagia Cuvelier, Cécile Naudin, Fatma Bouaziz, Guillaume Geri, Anne Couëdel-Courteille, Pierre Squara, Stefano Marullo, Rémi Cheynier
Thymic activation improves the outcome of COVID-19 patients with severe pneumonia. The rs2204985 genetic polymorphism within the TCRA-TCRD locus, which affects thymic output in healthy individuals, was found here to modify SARS-CoV-2-specific immunity and disease severity in COVID-19 patients with severe pneumonia. Forty patients with severe COVID-19 pneumonia were investigated. The GG genotype at the rs2204985 locus was associated, independently of age and sex, with stronger and long-lasting anti-SARS-CoV-2 helper and cytotoxic T cell responses 6 months after recovery...
September 22, 2023: Science Advances
#8
JOURNAL ARTICLE
Rabab El Hawary, Safa Meshaal, Sohilla Lotfy, Dalia Abd Elaziz, Radwa Alkady, Alia Eldash, Aya Erfan, Engy Chohayeb, Mai Saad, Rania Darwish, Jeannette Boutros, Nermeen Galal, Aisha Elmarsafy
Cernunnos deficiency is a rare genetic disorder characterized by immunodeficiency, microcephaly, growth retardation, bird-like facies, sensitivity to ionizing radiation, few autoimmune manifestations, premature aging of hematopoietic stem cells at an early age, and occasional myeloproliferative disease. Herein we present five Egyptian Cernunnos patients from 3 different families. We describe the patients' clinical phenotypes, their immunological profile as well as genetic results. Sequence analysis revealed three different mutations in the NHEJ1 gene: a nonsense variant c...
September 11, 2023: European Journal of Medical Genetics
#9
JOURNAL ARTICLE
Laura De Nardi, Marco Francesco Natale, Virginia Messia, Paolo Tomà, Fabrizio De Benedetti, Antonella Insalaco
BACKGROUND: Ataxia-telangiectasia (A-T) is a rare autosomal recessive DNA repair disorder, characterized by progressive cerebellar degeneration, telangiectasia, immunodeficiency, recurrent sinopulmonary infections, radiation sensitivity, premature aging and predisposition to cancer. Although the association with autoimmune and chronic inflammatory conditions such as vitiligo, thrombocytopenia and arthritis has occasionally been reported, an onset with articular involvement at presentation is rare...
September 4, 2023: Italian Journal of Pediatrics
#10
JOURNAL ARTICLE
Dong Li, Huan Yao, Xinfa Han, Xiaohan Cao, Xiaogang Du, Fengyan Meng, Guixian Bu, Fanli Kong, Tianzeng Song, Xianyin Zeng
Active immunization against gonadotropin-releasing hormone (GnRH) inhibits animal reproduction and has become a friendly alternative to surgical castration, which has been reported to affect the proportion of thymic T cell subpopulations. The effects of active immunization against GnRH on T cell migration from the thymus to the periphery and T cell distribution in lymphoid tissues remain unclear. Here, we showed that active immunization against GnRH increased thymic size and weight, enlarged the number of thymocytes, and enhanced CD4+ recent thymic emigrants (RTEs) and CD8+ RTEs migration to the blood and spleen...
August 9, 2023: Journal of Reproductive Immunology
#11
JOURNAL ARTICLE
Jonas Leonhard, Matthias Schaier, Florian Kälble, Martin Zeier, Andrea Steinborn
INTRODUCTION: Immunosuppressive therapy prevents graft rejection but increases the risk of non-melanoma skin cancer (NMSC), especially in elderly kidney transplant recipients (KTR). METHODS: In this study, we separately investigated the differentiation of CD8+ regulatory T cells (Tregs) and responder T cells (Tresps) between healthy KTR without NMSC, KTR developing de-novo NMSC within two years after the enrolment, and KTR with NMSC at the time of enrolment. Antigen-unexperienced CCR7+ CD45RA+ CD31+ recent thymic emigrant (RTE) cells differentiate via CD45RA- CD31+ memory (CD31+ memory) cells, via resting mature naïve (MN) cells or via direct proliferation into CD45RA- CD31- memory (CD31- memory) cells, consisting of both CCR7+ CD45RA- central memory (CM) and CCR7- CD45RA- effector memory (EM) cells...
2023: Frontiers in Immunology
#12
JOURNAL ARTICLE
Avijit Dutta, Chen-Yiu Hung, Tse-Ching Chen, Sung-Han Hsiao, Chia-Shiang Chang, Yung-Chang Lin, Chun-Yen Lin, Ching-Tai Huang
Excessive inflammation is a postulated cause of severe disease and death in respiratory virus infections. In response to severe influenza virus infection, adoptively transferred naïve hemagglutinin-specific CD4+ T cells from CD4+ TCR-transgenic 6.5 mice drive an IFN-γ-producing Th1 response in wild-type mice. It helps in virus clearance but also causes collateral damage and disease aggravation. The donor 6.5 mice have all the CD4+ T cells with TCR specificity toward influenza hemagglutinin. Still, the infected 6...
June 3, 2023: Communications Biology
#13
JOURNAL ARTICLE
Sintia Teichman, Helen Wang, Christina R Lee, Mahmood Mohtashami, Elisabeth Foerster, Jianxun Han, Ashton C Trotman-Grant, Shawn Winer, Hubert Tsui, Dana J Philpott, Juan Carlos Zúñiga-Pflücker
Recent thymic emigrant (RTE) cells are nascent T cells that continue their post-thymic maturation in the periphery and dominate T cell immune responses in early life and in adults having undergone lymphodepletion regimens. However, the events that govern their maturation and their functionality as they transition to mature naive T cells have not been clearly defined. Using RBPJind mice, we were able to identify different stages of RTE maturation and interrogate their immune function using a T cell transfer model of colitis...
May 8, 2023: Journal of Immunology
#14
JOURNAL ARTICLE
Dong Li, Lincai Li, Huan Yao, Qian Su, Junsong Ye
Thallium (Tl) is a high-priority toxic metal that poses a severe threat to human health. The toxicity characteristics induced by Tl have been partially discussed. However, the immunotoxic effects of Tl exposure have remained largely unexplored. Our findings demonstrated that 50 ppm of Tl exposure for one week induced severe weight loss in mice, which was accompanied by appetite suppression. Moreover, although Tl exposure did not induce significant pathological damage to skeletal muscle and bone, Tl inhibited the expression of B cell development-related genes in the bone marrow...
May 2, 2023: Toxicology
#15
JOURNAL ARTICLE
Lore Billiet, Laurenz De Cock, Guillem Sanchez Sanchez, Rupert L Mayer, Glenn Goetgeluk, Stijn De Munter, Melissa Pille, Joline Ingels, Hanne Jansen, Karin Weening, Eva Pascal, Killian Raes, Sarah Bonte, Tessa Kerre, Niels Vandamme, Ruth Seurinck, Jana Roels, Marieke Lavaert, Filip Van Nieuwerburgh, Georges Leclercq, Tom Taghon, Francis Impens, Björn Menten, David Vermijlen, Bart Vandekerckhove
In the human thymus, a CD10+ PD-1+ TCRαβ+ differentiation pathway diverges from the conventional single positive T cell lineages at the early double-positive stage. Here, we identify the progeny of this unconventional lineage in antigen-inexperienced blood. These unconventional T cells (UTCs) in thymus and blood share a transcriptomic profile, characterized by hallmark transcription factors (i.e., ZNF683 and IKZF2), and a polyclonal TCR repertoire with autoreactive features, exhibiting a bias toward early TCRα chain rearrangements...
June 5, 2023: Journal of Experimental Medicine
#16
JOURNAL ARTICLE
Akif Kavgacı, Deniz Bayrakoğlu, Sevgi Köstel Bal, Şule Haskoloğlu, Nisa Eda Çullas-İlarslan, Seda Topçu, Emel Okulu, Candan İslamoğlu, Meltem Arıkan, Figen Doğu, Kamile Aydan İkincioğulları
BACKGROUND: Early diagnosis and effective treatment serve as life-saving procedures for primary immunodeficiencies (PIDs) which are very common and a major public health problem in Turkey. Severe combined immunodeficiency (SCID) is constitutively a T-cell defect in which naïve T-cell development is defective due to the mutations in genes responsible for the T cell differentiation and insufficient thymopoiesis. So, assessment of thymopoiesis is very important in the diagnosis of SCID and several combined immune deficiencies (CIDs)...
2023: Turkish Journal of Pediatrics
#17
JOURNAL ARTICLE
Maria Carolina Dos Santos Guedes, Wlisses Henrique Veloso Carvalho-Silva, José Leandro Andrade-Santos, Maria Carolina Accioly Brelaz-de-Castro, Fabrício Oliveira Souto, Rafael Lima Guimarães
Decades of studies in antiretroviral therapy (ART) have passed, and the mechanisms that determine impaired immunological recovery in HIV-positive patients receiving ART have not been completely elucidated yet. Thus, T-lymphocytes immunophenotyping and cytokines levels were analyzed in 44 ART-treated HIV-positive patients who had a prolonged undetectable plasma viral load. The patients were classified as immunological non-responders (INR = 13) and immunological responders (IR = 31), according to their CD4+ T cell levels...
February 5, 2023: Viruses
#18
JOURNAL ARTICLE
Marco Lorenzini, Gergely Toldi
Recent thymic emigrants (RTEs) represent a distinct T cell subset characterized by a tolerance-prone status. We have recently demonstrated that the proportion of regulatory T cells (Tregs) is nearly two-fold higher in exclusively breastfed compared with exclusively formula-fed neonates. However, it has been unknown whether the type of milk is also associated with the proportion of the RTE cell compartment. Cord blood (CB) and, at three weeks of age, peripheral venous blood samples were collected from 19 healthy-term neonates...
February 18, 2023: Nutrients
#19
JOURNAL ARTICLE
Kenichiro Iio, Daijiro Kabata, Rei Iio, Shinichi Shibamoto, Yuuki Watanabe, Masashi Morita, Yosuke Imai, Masaki Hatanaka, Hiroki Omori, Yoshitaka Isaka
BACKGROUND: Chronic kidney disease (CKD) is age-related disease, and decreased renal function is associated with the premature aging of T cells and increased incidence of other age-related diseases. However, the relationship between T cell senescence and CKD progression remains unclear. Here, we investigated the relationship between T cell senescence, as indicated by decreased thymic output and increased proportion of highly differentiated CD28- T cells, and CKD progression. RESULTS: A total of 175 patients with non-dialysis-dependent CKD were enrolled in this study...
February 14, 2023: Immunity & Ageing: I & A
#20
JOURNAL ARTICLE
Antonio Giacomo Grasso, Roberto Simeone, Alessandra Maestro, Davide Zanon, Natalia Maximova
The use of anti-thymocyte globulin (ATG) as part of conditioning to prevent graft-versus-host disease (GVHD) may severely impair immune reconstitution (IR). We analyzed relationships between ATG exposure, the recipient lymphocyte count, IR, and transplant outcome. We retrospectively reviewed patients aged ≤ 18 years who underwent allogeneic HSCT between April 2005 and April 2020. The outcomes of interest included the incidence of GVHD, overall survival (OS), and IR. IR was analyzed through thymic magnetic resonance imaging (MRI) and by quantifying T CD4+ and recent thymic emigrants (RTEs)...
January 16, 2023: Journal of Clinical Medicine
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
