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JOURNAL ARTICLE
Yang Zhang, Yuqin Long, Yongjun Li, Dawei Liao, Linkun Hu, Ke Peng, Hong Liu, Fuhai Ji, Xisheng Shan
BACKGROUND: Remote ischemic conditioning (RIC) has the potential to benefit graft function following kidney transplantation by reducing ischemia-reperfusion injury; however, the current clinical evidence is inconclusive. This meta-analysis with trial sequential analysis (TSA) aimed to determine whether RIC improves graft function after kidney transplantation. METHODS: A comprehensive search was conducted on PubMed, Cochrane Library, and EMBASE databases until June 20, 2023, to identify all randomized controlled trials that examined the impact of RIC on graft function after kidney transplantation...
May 3, 2024: BMC Anesthesiology
#2
JOURNAL ARTICLE
Christin Rogers Marks, Christine M Durand, Mary G Bowring, Jonathan Hand, Maheen Z Abidi, Maricar Malinis, Brittany Barnaba, Het Patel, Martha Pavlakis, Carolyn D Alonso
PURPOSE: Kidney transplantation has a survival benefit for people with human immunodeficiency virus (HIV) and end-stage kidney disease, however increased rates of rejection remain an issue. Questions remain regarding the impact of induction immunosuppression therapy and antiretroviral (ARV) choice on long-term outcomes. METHODS: We performed a multicenter retrospective analysis of outcomes in recipients with HIV who received kidneys from donors without HIV transplanted between 2004 and 2019...
May 2, 2024: Transplant Infectious Disease: An Official Journal of the Transplantation Society
#3
JOURNAL ARTICLE
Pallav Gupta, Vinant Bhargava, Manish Malik, Anurag Gupta, A K Bhalla, Ashwani Gupta, Vaibhav Tiwari, Shiv Chadha, D S Rana
OBJECTIVES: Modern immunosuppressive regimens have reduced rejection episodes in renal allograft recipients but have increased the risk of opportunistic infections. Infections are considered to be the second leading cause of death after cardiovascular complications in renal allograft recipients. Data on opportunistic infections affecting the allograft itself are scarce. The present study describes the spectrum of renal opportunistic infections and their outcomes diagnosed on renal allograft biopsies and nephrectomy specimens...
March 2024: Experimental and Clinical Transplantation
#4
JOURNAL ARTICLE
Khalid Mahmood, Ahsan Ahmad, Rohit Upadhyay, Takallum Khatoon, Zaid Imbisat, Ankur Akela
BACKGROUND AND OBJECTIVES: End-stage renal disease (ESRD) rates are on the rise globally, including in India. However, the affordability of dialysis treatment remains a significant challenge for many, with costs varying across different regions. Although cost-effective, kidney transplantation faces challenges like a surgeon shortage, lack of infrastructure, and lack of logistic support. The study examines Indian laparoscopic nephrectomy outcomes and their benefits for donor recovery. It covers kidney donor procedural details, demographics, preoperative health evaluations, complications, and one-month follow-up...
March 2024: Curēus
#5
JOURNAL ARTICLE
Yueh-Tse Wu, Li-Min Hu, Chao-Wei Lee, Wei-Chen Lee, Jr-Rung Lin, Hsin-I Tsai, Huang-Ping Yu
BACKGROUND: Liver transplantation is treatment option for patients with end stage liver disease and hepatocellular carcinoma. Renal function deterioration significantly impacts the survival rates of liver recipients, and serum uric acid (SUA) is associated with both acute and chronic renal function disorders. Thus, our study aimed to assess the relationship and predictive value of preoperative SUA level and postoperative acute kidney injury (AKI) in living donor liver transplantation (LDLT)...
May 1, 2024: Journal of the Chinese Medical Association: JCMA
#6
REVIEW
Angie G Nishio Lucar, Ankita Patel, Shikha Mehta, Anju Yadav, Mona Doshi, Megan A Urbanski, Beatrice P Concepcion, Neeraj Singh, M Lee Sanders, Arpita Basu, Jessica L Harding, Ana Rossi, Oluwafisayo O Adebiyi, Milagros Samaniego-Picota, Kenneth J Woodside, Ronald F Parsons
Kidney transplantation is the most successful kidney replacement therapy available, resulting in improved recipient survival and societal cost savings. Yet, nearly 70 years after the first successful kidney transplant, there are still numerous barriers and untapped opportunities that constrain the access to transplant. The literature describing these barriers is extensive, but the practices and processes to solve them are less clear. Solutions must be multidisciplinary and be the product of strong partnerships among patients, their networks, health care providers, and transplant programs...
May 2024: Clinical Transplantation
#7
JOURNAL ARTICLE
Christie Rampersad, Curie Ahn, Chris Callaghan, Beatriz Dominguez-Gil, Gustavo F Ferreira, Vivek Kute, Axel O Rahmel, Minnie Sarwal, Jon Snyder, Haibo Wang, Germaine Wong, S Joseph Kim
BACKGROUND: The current landscape of organ donation and transplantation (ODT) registries is not well established. This narrative review sought to identify and characterize the coverage, structure, and data capture of ODT registries globally. METHODS: We conducted a literature search using Ovid Medline and web searches to identify ODT registries from 2000 to 2023. A list of ODT registries was compiled based on publications of registry design, studies, and reports...
April 30, 2024: Transplantation
#8
JOURNAL ARTICLE
Jaeyun Lee, Chan-Young Jung, Hyosang Kim, Hwa Jung Kim, Youngmin Ko, Hyunwook Kwon, Sung Shin, Young Hoon Kim, Su-Kil Park, Chung Hee Baek
BACKGROUND: Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers (ACEi/ARBs) can cause acute kidney injury under dehydratation or in hemodynamically unstable conditions. Regarding kidney transplantation (KT), the risk of using ACEi/ARBs before surgery is not well established. Therefore, we evaluated the clinical outcomes to determine the effect of preoperative use of ACEi/ARBs on KT. METHODS: We retrospectively collected 1187 patients who received living-donor KT between January 2017 and December 2021...
April 29, 2024: Journal of Nephrology
#9
JOURNAL ARTICLE
Hatem Ali, Mahmoud Mohammed, Miklos Z Molnar, Tibor Fülöp, Bernard Burke, Sunil Shroff, Arun Shroff, David Briggs, Nithya Krishnan
Outcome prediction for live-donor kidney transplantation improves clinical and patient decisions and donor selection. However, the concurrently used models are of limited discriminative or calibration power and there is a critical need to improve the selection process. We aimed to assess the value of various artificial intelligence (AI) algorithms to improve the risk stratification index. We evaluated pre-transplant variables among 66 914 live-donor kidney transplants (performed between 01/12/2007-01/06/2021) from the United Network of Organ Sharing database, randomized into training (80%) and test (20%) sets...
April 29, 2024: Nephrology, Dialysis, Transplantation
#10
JOURNAL ARTICLE
Lisa Ly, Danting Zhu, Douglas E Schaubel, Kenneth J Woodside, Randall S Sung
OBJECTIVE: Longer end-stage renal disease time has been associated with inferior kidney transplant outcomes. However, the contribution of transplant evaluation is uncertain. We explored the relationship between time from evaluation to listing (ELT) and transplant outcomes. METHODS: This retrospective study included 2535 adult kidney transplants from 2000 to 2015. Kaplan-Meier survival curves, log-rank tests, and Cox regression models were used to compare transplant outcomes...
May 2024: Clinical Transplantation
#11
JOURNAL ARTICLE
Andrea Noya-Mourullo, Alejandro Martín-Parada, Alberto Palacios-Hernández, Pablo Eguiluz-Lumbreras, Óscar Heredero-Zorzo, Francisco García-Gómez, José Luis Álvarez-Ossorio-Fernández, Andrea Álvarez-Ossorio-Rodal, Magaly-Teresa Márquez-Sánchez, Javier Flores-Fraile, Pilar Fraile-Gómez, Bárbara Yolanda Padilla-Fernández, María-Fernanda Lorenzo-Gómez
INTRODUCTION: The protocol for deceased donor kidney transplants has been standardised. The procedure for a living donor has peculiarities derived from the differences in the graft. When a living kidney donor program is implemented, changes occur in both the profile of the kidney transplant candidate and in the postoperative treatments. AIMS: To discover whether a living donor program influences the functional outcomes of kidney grafts in a longstanding classical deceased donor kidney transplant program and to identify the factors associated with transplant outcomes...
April 12, 2024: Journal of Personalized Medicine
#12
REVIEW
Katya Loban, Saly El Wazze, Théa Milland, Lindsay Hales, Anita Slominska, Shaifali Sandal
INTRODUCTION: Despite the lauded benefits of living kidney donation, there is growing evidence of the challenges that living kidney donors (LKD) encounter in their donation trajectory and gaps in healthcare service provision. However, most of the evidence is derived from research conducted by clinicians or academic investigators. Significantly less attention has been devoted to analyzing unsolicited accounts of LKDs' experiences. METHODS: We conducted a review and synthesis of published unsolicited first-person narratives of LKDs and aimed to synthesize their experiences and identify care needs...
April 10, 2024: Transplantation Reviews
#13
JOURNAL ARTICLE
Penina Dienstag, Rana Halsa, Keren Tzukert, Ashraf Imam, Abed Khalaileh, Aryeh Dienstag
Living donor kidney transplantation (LDKT) is one of the most effective treatment options for people suffering from end stage renal disease. Traditionally, LDKT can be either: "directed" or "non-directed," based on whether the recipient is specified by the donor. Recently there has been an increase in conditional and semidirected live kidney donation among strangers; where the donor specifies characteristics of the recipient whom they wish to donate to. This practice has both gained popularity and sparked controversy in the State of Israel through the non-profit organization Matnat Chaim...
April 17, 2024: American Journal of Transplantation
#14
JOURNAL ARTICLE
Brittany A Boerstra, Rianne Boenink, Megan E Astley, Marjolein Bonthuis, Samar Abd ElHafeez, Federico Arribas Monzón, Anders Åsberg, Pazit Beckerman, Samira Bell, Aleix Cases Amenós, Pablo Castro de la Nuez, Marc A G J Ten Dam, Alicja Debska-Slizien, Nikola Gjorgjievski, Rebecca Giudotti, Jaakko Helve, Kristine Hommel, Alma Idrizi, Ólafur S Indriðason, Faiçal Jarraya, Julia Kerschbaum, Kirill S Komissarov, Nadiia Kozliuk, Milica Kravljaca, Mathilde Lassalle, Johan M De Meester, Mai Ots-Rosenberg, Zoe Plummer, Danilo Radunovic, Olena Razvazhaieva, Halima Resic, Olga Lucía Rodríguez Arévalo, Carmen Santiuste de Pablos, Nurhan Seyahi, María Fernanda Slon-Roblero, Maria Stendahl, Miloreta Tolaj-Avdiu, Sara Trujillo-Alemán, Ieva Ziedina, Edita Ziginskiene, Alberto Ortiz, Kitty J Jager, Vianda S Stel, Anneke Kramer
BACKGROUND: The European Renal Association (ERA) Registry collects data on kidney replacement therapy (KRT) in patients with end-stage kidney disease (ESKD). This paper is a summary of the ERA Registry Annual Report 2021, including a comparison across treatment modalities. METHODS: Data was collected from 54 national and regional registries from 36 countries, of which 35 registries from 18 countries contributed individual patient data and 19 registries from 19 countries contributed aggregated data...
February 2024: Clinical Kidney Journal
#15
JOURNAL ARTICLE
Muthukumarassamy Rajakannu, Ashwin Rammohan, Gomathy Narasimhan, Sivakumar Murugesan, Rajesh Rajalingam, Kumar Palaniappan, Sandeep Jasper Rajasekar, Dinesh Jothimani, Akila Rajakumar, Ilankumaran Kaliamoorthy, Mohamed Rela
BACKGROUND: Paucity of deceased donor livers has resulted in a 10-fold rise in living donor liver transplantations (LDLTs) performed in India over the past decade. Nonetheless, number of deceased donor liver transplantation (DDLT) performed has improved with the establishment of simplified legal framework for certification of brain death and organ donation. In this study, we present our outcomes of DDLT performed at various centers, comparing their outcomes and provide a snapshot of the increasing number of DDLT across the state over the years...
April 19, 2024: Transplantation
#16
JOURNAL ARTICLE
Francesc Vigués, Begoña Etcheverry, José I Perez Reggeti, Josep Maria Gaya, Angelo Territo, Andrea Gallioli, Camille Berquin, Giuseppe Basile, José F Suárez, Maria Fiol, Oscar Buisan, Lluís Riera, Thomas Prudhomme, Nicolas Doumerc, Alessio Pecoraro, Alberto Breda
BACKGROUND AND OBJECTIVE: Orthotopic kidney transplantation (KT) has been proposed as an option for patients ineligible for heterotopic KT. In this scenario, orthotopic robot-assisted KT (oRAKT) represents a novel, minimally invasive alternative to the open approach. Here we describe the largest oRAKT series of patients, with a focus on the surgical technique, perioperative surgical outcomes, and functional results. METHODS: We queried prospectively maintained databases from three referral centers to identify patients who underwent oRAKT and evaluated surgical and functional outcomes...
April 15, 2024: European Urology
#17
Clara Schott, Samantha Colaiacovo, Cadence Baker, Matthew A Weir, Dervla M Connaughton
RATIONALE: Alport Syndrome (AS) is a progressive genetic condition characterized by chronic kidney disease (CKD), hearing loss, and eye abnormalities. It is caused by mutations in the genes COL4A3, COL4A4 , and COL4A5 . Heterozygous mutations in COL4A4 and COL4A3 cause autosomal dominant Alport Syndrome (ADAS), and a spectrum of phenotypes ranging from asymptomatic hematuria to CKD, with variable extra-renal features. In the past, heterozygous mutations in these genes were thought to be benign, however recent studies show that about 30% of patients can progress to CKD, and 15% can progress to end stage kidney disease (ESKD)...
2024: Canadian Journal of Kidney Health and Disease
#18
JOURNAL ARTICLE
Rikako Oki, Kohei Unagami, Taro Banno, Toshihito Hirai, Kazuya Omoto, Tomokazu Shimizu, Sekiko Taneda, Junichi Hoshino, Toshio Takagi, Hideki Ishida
BACKGROUND: The number of marginal living kidney donors has increased. Medically complex donors who have hypertension, older age, or low estimated glomerular filtration rate (eGFR) have been more likely to be used. METHODS: We conducted a retrospective cohort study of living kidney donors at a single center. We analyzed 309 living donors and divided them into three groups: group with older donors (aged ≥70 years) (n = 41), middle-aged (aged 46-69 years) (n = 239), and young donors (aged <46 years) (N = 29)...
April 14, 2024: Clinical and Experimental Nephrology
#19
EDITORIAL
Amy D Waterman, LaShara A Davis, Solaf Al Awadhi
No abstract text is available yet for this article.
April 11, 2024: American Journal of Kidney Diseases
#20
JOURNAL ARTICLE
Michiel G H Betjes, Marcia M L Kho, Joke Roodnat, Annelies E de Weerd
Background : The number of kidney transplant recipients over 70 years of age is increasing but detailed data on patient and graft survival in the modern era of immune suppression are few. Methods : A single-center cohort of patients of 70 years and older (n = 349) at time of kidney transplantation from 2010-2020 were followed until January 2023. Results : The median age was 73 years with a median follow-up of 4.3 years. Fifty percent of recipients of a living donor kidney (LDK, n = 143) received their graft pre-emptively...
March 23, 2024: Journal of Clinical Medicine
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