Mariana de Melo Cardoso, Rahisa Scussel, Jessica da Silva Abel, Fernando Oriques Pereira, Lidiane Anastácio Cruz, Franciane da Costa Constante, Ellen De Pieri, Helena Mendes Abelaira, Juliano Ferreira, Marcus Vinícius Gomez, Flávia K Rigo, Ricardo Andrez Machado-de-Ávila
Cancer-related pain is considered one of the most prevalent symptoms for those affected by cancer, significantly influencing quality of life and treatment outcomes. Morphine is currently employed for analgesic treatment in this case, however, chronic use of this opioid is limited by the development of analgesic tolerance and adverse effects, such as digestive and neurological disorders. Alternative therapies, such as ion channel blockade, are explored. The toxin Phα1β has demonstrated efficacy in blocking calcium channels, making it a potential candidate for alleviating cancer-related pain...
April 11, 2024: Toxicon: Official Journal of the International Society on Toxinology