Jens Stepan, Daniel E Heinz, Frederik Dethloff, Svenja Wiechmann, Silvia Martinelli, Kathrin Hafner, Tim Ebert, Ellen Junglas, Alexander S Häusl, Max L Pöhlmann, Mira Jakovcevski, Julius C Pape, Anthony S Zannas, Thomas Bajaj, Anke Hermann, Xiao Ma, Hermann Pavenstädt, Mathias V Schmidt, Alexandra Philipsen, Christoph W Turck, Jan M Deussing, Gerhard Rammes, Andrew C Robinson, Antony Payton, Michael C Wehr, Valentin Stein, Christopher Murgatroyd, Joachim Kremerskothen, Bernhard Kuster, Carsten T Wotjak, Nils C Gassen
The localization, number, and function of postsynaptic AMPA-type glutamate receptors (AMPARs) are crucial for synaptic plasticity, a cellular correlate for learning and memory. The Hippo pathway member WWC1 is an important component of AMPAR-containing protein complexes. However, the availability of WWC1 is constrained by its interaction with the Hippo pathway kinases LATS1 and LATS2 (LATS1/2). Here, we explored the biochemical regulation of this interaction and found that it is pharmacologically targetable in vivo...
April 30, 2024: Science Signaling