Kanako Yuki, Mario Vallon, Jie Ding, Cara C Rada, Alan T Tang, José G Vilches-Moure, Aaron K McCormick, Maria F Henao Echeverri, Samira Alwahabi, Barbara M Braunger, Süleyman Ergün, Mark L Kahn, Calvin J Kuo
The GPR124/RECK/WNT7 pathway is an essential regulator of CNS angiogenesis and blood-brain barrier (BBB) function. GPR124, a brain endothelial adhesion 7-pass transmembrane protein, associates with RECK, which binds and stabilizes newly synthesized WNT7, which is transferred to Frizzled (FZD) to initiate canonical b-catenin signaling. GPR124 remains enigmatic; while its extracellular domain (ECD) is essential, the poorly conserved intracellular domain (ICD) appears variably required in mammals versus zebrafish, potentially via adaptor protein bridging of GPR124/FZD ICDs...
April 29, 2024: Development