Seth J Concors, Paul T Hernandez, Ciaran O'Brien, John DePaolo, Douglas R Murken, David D Aufhauser, Zhonglin Wang, Yan Xiong, Lauren Krumeich, Guanghui Ge, Ulf H Beier, Tricia R Bhatti, Alan P Kozikowski, Leandro A Alves Avelar, Thomas Kurz, Wayne W Hancock, Matthew H Levine
BACKGROUND: Ischemia-reperfusion injury (IRI) causes significant morbidity in liver transplantation among other medical conditions. IRI following liver transplantation contributes to poor outcomes and early graft loss. Histone/protein deacetylases (HDACs) regulate diverse cellular processes, play a role in mediating tissue responses to IRI, and may represent a novel therapeutic target in preventing IRI in liver transplantation. METHODS: Using a previously described standardized model of murine liver warm IRI, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were assessed at 24 and 48 h after reperfusion to determine the effect of different HDAC inhibitors...
April 30, 2024: Transplantation