Yichao Wu, Changbiao Li, Abid Ali Khan, Kangchen Chen, Renyi Su, Shengjun Xu, Yiyang Sun, Fengqiang Gao, Kai Wang, Xiaodong Wang, Zhengxing Lian, Shuo Wang, Mengyuan Yu, Xin Hu, Fan Yang, Shusen Zheng, Nasha Qiu, Zhikun Liu, Xiao Xu
BACKGROUND: Hepatic ischemia-reperfusion (IR) injury is the primary reason for complications following hepatectomy and liver transplantation (LT). Insulin-induced gene 2 (Insig2) is one of several proteins that anchor the reticulum in the cytoplasm and is essential for metabolism and inflammatory responses. However, its function in IR injury remains ambiguous. METHODS: Insig2 global knock-out (KO) mice and mice with adeno-associated-virus8 (AAV8)-delivered Insig2 hepatocyte-specific overexpression were subjected to a 70% hepatic IR model...
October 19, 2023: Journal of Translational Medicine