Zhongyun Zhang, Ning Zhang, Xuancheng Lu, Min Zhou, Xiaoxiang Yan, Weiqiong Gu, Jingru Yang, Qin Zhang, Cheng Zhang, Yuhuan Gong, Mingjun Jia, Xiaoyu Zhang, Peng Ning, Mei Liu, Xiaoyan Li, Xiaomeng Shi, Wenjun Liu, George F Gao, Guang Ning, Jiqiu Wang, Yuhai Bi
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can result in more severe syndromes and poorer outcomes in patients with diabetes and obesity. However, the precise mechanisms responsible for the combined impact of corona virus disease 2019 (COVID-19) and diabetes have not yet been elucidated, and effective treatment options for SARS-CoV-2-infected diabetic patients remain limited. To investigate the disease pathogenesis, K18-hACE2 transgenic (hACE2 Tg ) mice with a leptin receptor deficiency (hACE2-Lepr -/- ) or high-fat diet (hACE2-HFD) background were generated...
November 18, 2023: Zoological Research