Joana L Fernandes, Fátima O Martins, Elena Olea, Jesus Prieto-Lloret, Patrícia C Braga, Joana F Sacramento, Catarina O Sequeira, Ana P Negrinho, Sofia A Pereira, Marco G Alves, Asunción Rocher, Silvia V Conde
The association between obstructive sleep apnea (OSA) and metabolic disorders is well-established; however, the underlying mechanisms that elucidate this relationship remain incompletely understood. Since the liver is a major organ in the maintenance of metabolic homeostasis, we hypothesize that liver dysfunction plays a crucial role in the pathogenesis of metabolic dysfunction associated with obstructive sleep apnea (OSA). Herein, we explored the underlying mechanisms of this association within the liver. Experiments were performed in male Wistar rats fed with a control or high fat (HF) diet (60% lipid-rich) for 12 weeks...
October 25, 2023: Antioxidants (Basel, Switzerland)