Yuxin Mi, Katie L Burnham, Philip D Charles, Raphael Heilig, Iolanda Vendrell, Justin Whalley, Hew D Torrance, David B Antcliffe, Shaun M May, Matt J Neville, Georgina Berridge, Paula Hutton, Cyndi G Geoghegan, Jayachandran Radhakrishnan, Alexey I Nesvizhskii, Fengchao Yu, Emma E Davenport, Stuart McKechnie, Roger Davies, David J P O'Callaghan, Parind Patel, Ana G Del Arroyo, Fredrik Karpe, Anthony C Gordon, Gareth L Ackland, Charles J Hinds, Roman Fischer, Julian C Knight
Sepsis, the dysregulated host response to infection causing life-threatening organ dysfunction, is a global health challenge requiring better understanding of pathophysiology and new therapeutic approaches. Here, we applied high-throughput tandem mass spectrometry to delineate the plasma proteome for sepsis and comparator groups (noninfected critical illness, postoperative inflammation, and healthy volunteers) involving 2612 samples (from 1611 patients) and 4553 liquid chromatography-mass spectrometry analyses acquired through a single batch of continuous measurements, with a throughput of 100 samples per day...
June 5, 2024: Science Translational Medicine