Grzegorz Laskawski, Abdelrahman Abdelbar, Joseph Zacharias
Post-myocardial infarction (MI) ventricular septal defect (VSD) is a serious condition that is, fortunately, less diagnosed nowadays due to the advances in early diagnosis and treatment of ischaemic heart disease (incidence 1-2%). Despite the lower mortality of both surgical and interventional closure of the defect (25%) as compared to medical therapy (40-50%), there are still risks of residual leak in both approaches. Herein, we describe a case of a successful endoscopic-assisted repair of a delayed residual leak post-MI VSD after surgical repair...
October 1, 2020: Interactive Cardiovascular and Thoracic Surgery
Barbara M Johnston, Peter R Johnston
Modelling the electrical activity of the heart is an important tool for understanding electrical function in various diseases and conduction disorders. Clearly, for model results to be useful, it is necessary to have accurate inputs for the models, in particular the commonly used bidomain model. However, there are only three sets of four experimentally determined conductivity values for cardiac ventricular tissue and these are inconsistent, were measured around 40 years ago, often produce different results in simulations and do not fully represent the three-dimensional anisotropic nature of cardiac tissue...
October 22, 2020: Medical & Biological Engineering & Computing
Laureen Yi-Ting Wang, Gavin Yeow Ping Ng
Background: COVID-19 infection is the most serious global public health crisis of the century. With no approved treatments against it, investigational treatments are being used despite limited safety data. Besides being at higher risk of complications of COVID-19 infection, patients with underlying cardiovascular disease are more likely to develop cardiac-related side effects of treatment. We present a case of sinus arrest with junctional escape related to lopinavir-ritonavir. Case summary: A 67-year-old man, with underlying stable ischaemic heart disease, acquired COVID-19 infection...
October 2020: European Heart Journal. Case Reports
Raphael Caraffa, Lorenzo Bagozzi, Alessandro Fiocco, Olimpia Bifulco, Matteo Nadali, Matteo Ponzoni, Massimiliano Carrozzini, Giuseppe Toscano, Angela Pompea Fraiese, Marco Metra, Carlo Maria Lombardi, Francesco Serafini, Angela Ribola, Vjola Jorgji, Tomaso Bottio, Gino Gerosa
OBJECTIVES: Few anecdotal cases have been reported in the literature regarding heart transplant recipients and infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report our experience with 6 patients hospitalized in Northern Italy during the outbreak. METHODS: Of the 396 living heart transplant recipients from 1985 to 2020 included in the study, 6 patients developed the novel 2019 coronavirus disease. Risk factors, last follow-up characteristics, onset presentation, in-hospital course of disease and blood examinations data were collected for these patients...
November 1, 2020: European Journal of Cardio-thoracic Surgery
Xinglong Han, Zhen-Ao Zhao, Shiping Yan, Wei Lei, Hongchun Wu, Xing-Ai Lu, Yueqiu Chen, Jingjing Li, Yaning Wang, Miao Yu, Yongming Wang, Yufang Zheng, Hongyan Wang, Zhenya Shen, Shijun Hu
Myocardial infarction (MI) results in cardiomyocyte death and ultimately leads to heart failure. Pyroptosis is a type of the inflammatory programmed cell death that has been found in various diseased tissues. However, the role of pyroptosis in MI heart remains unknown. Here, we showed that CXADR-like membrane protein (CLMP) was involved in pyroptosis in the mouse MI heart. Our data showed that CLMP was strongly expressed in fibroblasts of the infarcted mouse hearts. The Clmp+/- mice showed more serious myocardial fibrosis and ventricular dysfunction post-MI than wild-type (Clmp+/+ ) mice, indicating a protective effect of the fibroblast-expressed CLMP against MI-induced heart damage...
October 21, 2020: Journal of Cellular and Molecular Medicine
Fiona Doig, Zhen Qi Lu, Susan Smith, Rishendran Naidoo
BACKGROUND: Ischaemic mitral regurgitation (IMR) is associated with an increase in both mortality and congestive heart failure in patients undergoing coronary artery bypass grafting (CABG). Intervention for moderate to severe IMR involves either valve repair or replacement. The ideal option is yet to be fully defined with relatively poor long-term survival being noted in the literature. METHOD: A retrospective observational study was conducted to review the outcomes of patients undergoing CABG in combination with either mitral valve repair (MVr) or mitral valve replacement (MVR) for concurrent coronary artery disease with moderate to severe IMR at The Prince Charles Hospital in Brisbane between the years 2002 to 2015...
October 17, 2020: Heart, Lung & Circulation
Ki Hong Choi, Young Bin Song, Dong Seop Jeong, Yong Ho Jang, David Hong, Sang Yoon Lee, Taeho Youn, Minjung Bak, Kyung Min Min, Joo Myung Lee, Taek Kyu Park, Jeong Hoon Yang, Joo-Yong Hahn, Jin-Ho Choi, Seung-Hyuk Choi, Su Ryeun Chung, Yang Hyun Cho, Kiick Sung, Wook Sung Kim, Hyeon-Cheol Gwon, Young Tak Lee
AIMS: The current study sought to evaluate whether long-term clinical outcomes according to the use of dual antiplatelet therapy (DAPT) or single antiplatelet therapy (SAPT) differed between acute coronary syndrome (ACS) and stable ischaemic heart disease (SIHD) patients who underwent coronary artery bypass grafting surgery (CABG). METHODS AND RESULTS: Between January 2001 and December 2017, 3199 patients with ACS (55.3%) and 2583 with SIHD (44.7%) who underwent isolated CABG were enrolled...
July 6, 2020: European Heart Journal. Cardiovascular Pharmacotherapy
Akshay J Patel, Saifullah Mohamed, Yassir Iqbal, Ashok Kar, Gopal Soppa
Ischaemic heart disease and aortic stenosis are potentially life-threatening conditions. A post-infarct left ventricular aneurysm, when combined with the above, is particularly hazardous. We present a case where all three conditions occurred simultaneously and describe the surgical approach undertaken to attempt correction. The patient underwent aneurysmectomy together with aortic valve replacement and two-vessel coronary artery bypass grafting. The aneurysm was excised with direct linear closure of the walls using a Teflon-buttressed interrupted mattress suture technique...
October 2020: Journal of Surgical Case Reports
Ignacio Roy, Lorena Malagon, Javier Martínez, Javier Romero, Aitziber Munarriz, Nuria Basterra
INTRODUCTION AND OBJECTIVES: implantable cardiac defibrillator (ICD) has been established as a therapy for malignant ventricular arrhythmias in patients at high risk of suffering them. Some studies suggest a possible relationship between the development of cancer and some prosthetic materials. Likewise, some investigations describe a higher incidence of cancer in patients with an ICD that suggest a potential relationship. METHODS: Retrospective cohort study of patients that underwent implantation of an ICD in the Complejo Hospitalario de Navarra between 2000 and 2016...
October 14, 2020: Medicina Clínica
(no author information available yet)
BACKGROUND: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries...
October 17, 2020: Lancet
Kuan Ken Lee, Rong Bing, Joanne Kiang, Sophia Bashir, Nicholas Spath, Dominik Stelzle, Kevin Mortimer, Anda Bularga, Dimitrios Doudesis, Shruti S Joshi, Fiona Strachan, Sophie Gumy, Heather Adair-Rohani, Engi F Attia, Michael H Chung, Mark R Miller, David E Newby, Nicholas L Mills, David A McAllister, Anoop S V Shah
BACKGROUND: 3 billion people worldwide rely on polluting fuels and technologies for domestic cooking and heating. We estimate the global, regional, and national health burden associated with exposure to household air pollution. METHODS: For the systematic review and meta-analysis, we systematically searched four databases for studies published from database inception to April 2, 2020, that evaluated the risk of adverse cardiorespiratory, paediatric, and maternal outcomes from exposure to household air pollution, compared with no exposure...
November 2020: Lancet Global Health
Michael A Nauck, Daniel R Quast, Jakob Wefers, Juris J Meier
GLP-1 receptor agonists (GLP-1 RAs), with exenatide b.i.d. first approved for the treatment of type 2 diabetes in 2005, have been further developed to yield effective compounds/preparations, which have overcome the original problem of rapid elimination (short half-life), initially necessitating short intervals between injections (twice daily for exenatide b.i.d.). Today, GLP-1 RAs are injected twice daily (exenatide b.i.d.), once daily (lixisenatide, liraglutide) or once weekly (exenatide once weekly, dulaglutide, albiglutide, semaglutide)...
October 14, 2020: Molecular Metabolism
Prakriti Gaba, Bernard J Gersh, Ziad A Ali, Jeffrey W Moses, Gregg W Stone
Coronary artery disease is the leading cause of morbidity and mortality worldwide. Selected patients with obstructive coronary artery disease benefit from revascularization with percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) surgery. Many (but not all) studies have demonstrated increased survival and greater freedom from adverse cardiovascular events after complete revascularization (CR) than after incomplete revascularization (ICR) in patients with multivessel disease. However, achieving CR after PCI or CABG surgery might not be feasible owing to patient comorbidities, anatomical factors, and technical or procedural considerations...
October 16, 2020: Nature Reviews. Cardiology
N A Kochergin, A M Kochergina, V I Ganiukov
Acute coronary syndrome has for a long time been giving no way of decreasing mortality related to ischaemic heart disease. The primary cause of acute coronary syndrome in the majority of cases is rupture of an unstable atherosclerotic plaque in the coronary artery followed by thrombosis thereof. The main missions of modern cardiology include: assessment of the risk of acute coronary syndrome, identification of predictors of adverse events, and working-out of measures aimed at prevention and optimal management of patients with ischaemic heart disease...
2020: Angiology and Vascular Surgery
A A Fokin, K A Kireev, S V Netisanov
AIM: The study was aimed at comparatively assessing the immediate results of coronary artery bypass grafting operations without artificial circulation performed in non-ST-segment elevation acute myocardial infarction and chronic ischaemic heart disease. PATIENTS AND METHODS: The main group with non-ST-segment elevation acute myocardial infarction enrolled a total of 101 patients undergoing coronary artery bypass grafting without artificial circulation. The patients' age varied from 47 to 87 years, median 66...
2020: Angiology and Vascular Surgery
Stuart Moss, Mathew Doyle, Regina Hong, Con Manganas, Sheen Peeceeyen
Background: The era of percutaneous aortic valve intervention has challenged the continuing indication for surgical aortic valve replacement (SAVR). Aim: The aim of this study is to evaluate clinical outcomes of the elderly patients who underwent surgical aortic valve replacement via median sternotomy, in order to assess the impact of surgery on patient outcomes and discharge destination. Methods: The study involves a retrospective observational analysis in a single centre, including all octogenarian patients who underwent aortic valve surgery between January of 2011 and July of 2016...
March 2020: Indian Journal of Thoracic and Cardiovascular Surgery
Mika Kivimäki, Marianna Virtanen, Solja T Nyberg, G David Batty
Working hours is a ubiquitous exposure given that most adults are employed, and one that is modifiable via legislative change if not always through individual-level choice. According to a recent report from the World Health Organization (WHO) and International Labour Organization (ILO), there is currently sufficient evidence to conclude that long working hours (i.e., ≥55 h per week) elevate the risk of fatal and non-fatal ischaemic heart disease to a clinically meaningful extent. After assessing the data used by the ILO/WHO, we feel that the expert group has not correctly applied their own framework for assessing the strength of the evidence...
November 2020: Environment International
Ana Isabel González-González, Lilisbeth Perestelo-Pérez, Débora Koatz, Marta Ballester, Valeria Pacheco-Huergo, Vanesa Ramos-García, Alezandra Torres-Castaño, Amado Rivero-Santana, Ana Toledo-Chávarri, Cristina Valcárcel-Nazco, Juana Mateos-Rodilla, Juan Carlos Obaya-Rebollar, Javier García-García, Santiago Díaz-Sánchez, Luis Morales-Cobos, Josep María Bosch-Fontcuberta, Nuria Vallejo-Camazón, Ana Rodríguez-Almodovar, José Carlos Del Castillo, Marcos Muñoz-Balsa, Yolanda Del Rey-Granado, Sofía Garrido-Elustondo, María-Eugenia Tello-Bernabé, Ana Belén Ramírez-Puerta, Carola Orrego
INTRODUCTION: Virtual Communities of Practice (VCoP) or knowledge-sharing virtual communities offer ubiquitous access to information and exchange possibilities for people in similar situations, which might be especially valuable for the self-management of patients with chronic diseases. In view of the scarce evidence on the clinical and economic impact of these interventions on chronic conditions, we aim to evaluate the effectiveness and cost-effectiveness of a VCoP in the improvement of the activation and other patient empowerment measures in patients with ischaemic heart disease (IHD)...
October 12, 2020: BMJ Open
Boldizsar Kovacs, Sven Reek, Christian Sticherling, Beat Schaer, André Linka, Peter Ammann, Roman Brenner, Nazmi Krasniqi, Andreas S Müller, Omer Dzemali, Richard Kobza, Christian Grebmer, Laurent Haegeli, Jan Berg, Kurt Mayer, Jürg Schläpfer, Giulia Domenichini, Tobias Reichlin, Laurent Roten, Harran Burri, Urs Eriksson, Ardan M Saguner, Jan Steffel, Firat Duru, Swiss Wcd Registry
INTRODUCTION: Sudden cardiac death caused by malignant arrhythmia can be prevented by the use of defibrillators. Although the wearable cardioverter defibrillator (WCD) can prevent such an event, its role in clinical practice is ill defined. We investigated the use of the WCD in Switzerland with emphasis on prescription rate, therapy adherence and treatment rate. MATERIALS AND METHODS: The Swiss WCD Registry is a retrospective observational registry including patients using a WCD...
September 21, 2020: Swiss Medical Weekly
Cushla Coffey, Yuejen Zhao, John R Condon, Shu Li, Steven Guthridge
OBJECTIVES: To examine long-term trends in acute myocardial infarction (AMI) incidence and survival among Aboriginal and non-Aboriginal people. DESIGN: Retrospective cohort study. SETTING, PARTICIPANTS: All first AMI hospital cases and deaths due to ischaemic heart disease in the Northern Territory of Australia (NT), 1992-2014. MAIN OUTCOME MEASURES: Age standardised incidence, survival and mortality. RESULTS: The upward trend in Aboriginal AMI incidence plateaued around 2007 for males and 2001 for females...
October 8, 2020: BMJ Open
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