Mara Sneidere, Harald Heinrich Schrem, Jan Christoph Mahlmann, Oliver Beetz, Sebastian Cammann, Felix Oldhafer, Moritz Kleine, Juergen Klempnauer, Alexander Kaltenborn, Ulrich Zwirner, Ulf Kulik
BACKGROUND: Prognostic models to predict individual early postoperative morbidity after liver resection for colorectal liver metastases (CLM) are not available but could enable optimized preoperative patient selection and postoperative surveillance for patients at greater risk of complications. The aim of this study was to establish a prognostic model for the prediction of morbidity after liver resection graded according to Dindo. METHODS: N = 679 cases of primary liver resection for CLM were retrospectively analyzed using univariable and multivariable ordinal regression analyses...
October 22, 2020: Zentralblatt Für Chirurgie
Matthew W Zackoff, Daniel Young, Rashmi D Sahay, Lin Fei, Francis J Real, Amy Guiot, Corinne Lehmann, Melissa Klein
OBJECTIVE: The Association of American Medical Colleges defines recognition of the need for urgent or emergent escalation of care as a key Entrustable Professional Activity (EPA) for entering residency (EPA#10). This study pilots the use of an immersive virtual reality (VR) platform for defining objective observable behaviors as standards for evaluation of medical student recognition of impending respiratory failure. METHODS: A cross-sectional observational study was conducted from July 2018-December 2019, evaluating student performance during a VR scenario of an infant in impending respiratory failure using the OculusRift™ VR platform...
October 19, 2020: Academic Pediatrics
Jade André de Souza, Yasmin Beatrisse Klein Patel, Heloise Adeli Grockoski, Roberta Nunes, Silvia Aparecida Ramos, Maria Verônica Dávila Pastor, Luis Carlos Stoeberl, Adriana Campos, Valdir Cechinel Filho, José Roberto Santin, Nara Lins Meira Quintão
ETHNOPHARMACOLOGICAL RELEVANCE: Synadenium grantii Hook. f., popularly known as "janaúba" or "leiterinha", is used in the folk medicine to treat gastric disorders, some types of neoplasias and inflammatory diseases. AIM OF THE STUDY: The aim of this study was to show the anti-inflammatory activity of the methanol extract obtained from S. grantii stems and also certify the safety of the extract performing toxicological analysis. MATERIAL AND METHODS: The anti-inflammatory activity was investigated using carrageenan-induced inflammation in the subcutaneous tissue of male Swiss mice orally pre-treated with the S...
October 19, 2020: Journal of Ethnopharmacology
Jamilah M Hackworth, Jareen Meinzen-Derr, Mallory DePalma, Margaret Hostetter, Melissa Klein, Jennifer K O'Toole, Jessica Kahn
No abstract text is available yet for this article.
October 19, 2020: Journal of Pediatrics
Harish Narasimhan, Anna Chudnovets, Irina Burd, Andrew Pekosz, Sabra L Klein
In utero Zika virus (ZIKV; family Flaviviridae) infection causes a distinct pattern of birth defects and disabilities in the developing fetus and neonate that has been termed congenital zika syndrome (CZS). Over 8,000 children were affected by the 2016 to 2017 ZIKV outbreak in the Americas, many of whom developed CZS as a result of in utero exposure. To date, there is no consensus about how ZIKV causes CZS; animal models, however, are providing mechanistic insights. Using nonhuman primates, immunocompromised mice, immunocompetent mice, and other animal models (e...
October 2020: PLoS Neglected Tropical Diseases
H H K Wilson, R Norris, A Tapley, P Magin, L Klein
Australian general practitioners (GPs) see most Australians each year and, as tobacco, alcohol and other drug use (substance use) are common, GPs often see problematic, risky or dependent substance use. This study aimed to explore early-career GPs' role legitimacy, comfort and confidence managing patients with problematic use of tobacco, alcohol, psychoactive pharmaceutical or illicit substances. Using the '5A's framework: Ask, Assess, Advise, Assist and Arrange, we surveyed 251 early-career GPs (GP registrars) on role legitimacy, confidence managing patient substance use, and sources of clinical information, advice and support...
October 22, 2020: Education for Primary Care
Joost Reek, Joeri Hessels, Eduard Masferrer-Rius, Fengshou Yu, Remko J Detz, Robertus J M Klein-Gebbink
The development of novel water oxidation catalysts is important in the context of renewable fuels production. Ligand design is one of the key tools to improve the activity and stability of molecular catalysts. The establishment of ligand design rules can facilitate the development of improved molecular catalysts. In this paper we show that chemical oxidants can be used to probe oxygen evolution activity for nickel-based systems and report trends that can improve future ligand design. Interestingly, we observe different ligand effects in comparison to other first-row transition metal complexes...
October 14, 2020: ChemSusChem
Gottfried Unden, Robin Klein
Many bacteria are able to use O2 and nitrate as alternative electron acceptors for respiration. Strategies for regulation in response to O2 and nitrate can vary considerably. In the paradigmatic system of E. coli (and γ-proteobacteria), regulation by O2 and nitrate is established by the O2 -sensor FNR and the two-component system NarX-NarL (for nitrate regulation). Expression of narGHJI is regulated by the binding of FNR and NarL to the promoter. A similar strategy by individual regulation in response to O2 and nitrate is verified in many genera by the use of various types of regulators...
October 22, 2020: Environmental Microbiology
Conrad M Freuling, Angele Breithaupt, Thomas Müller, Julia Sehl, Anne Balkema-Buschmann, Melanie Rissmann, Antonia Klein, Claudia Wylezich, Dirk Höper, Kerstin Wernike, Andrea Aebischer, Donata Hoffmann, Virginia Friedrichs, Anca Dorhoi, Martin H Groschup, Martin Beer, Thomas C Mettenleiter
Raccoon dogs might have been intermediate hosts for severe acute respiratory syndrome-associated coronavirus in 2002-2004. We demonstrated susceptibility of raccoon dogs to severe acute respiratory syndrome coronavirus 2 infection and transmission to in-contact animals. Infected animals had no signs of illness. Virus replication and tissue lesions occurred in the nasal conchae.
October 22, 2020: Emerging Infectious Diseases
C A Onate, M C Onyeaju, D T Bankole, A N Ikot
An approximate solution of the one-dimensional relativistic Klein-Gordon equation was obtained under the interaction of an improved expression for Wei potential energy function. The solution of the non-relativistic Schrödinger equation was obtained from the solution of the relativistic Klein-Gordon equation by certain mappings. We have calculated Fisher information for position space and momentum space via the computation of expectation values. The effects of some parameters of the Wei potential energy function on the Fisher information were fully examined graphically...
October 21, 2020: Journal of Molecular Modeling
Diego Candido Abreu, Aline Silva Gomes, Danielle Klein Tessler, Daniela Pontes Chiebao, Cláudia Del Fava, Adriana Hellmeister de Campos Nogueira Romaldini, Mateus Carvalho Araujo, Júlio Pompei, Guilherme Figueiredo Marques, Ricardo Harakava, Edviges Maristela Pituco, Alessandra Figueiredo de Castro Nassar
Glanders is an equine zoonosis caused by Burkholderia mallei that is responsible for considerable economic loss. Complement fixation testing (CFT) using warm or cold incubation are recommended by the OIE, but many routinely used detection tests may present misleading results. To increase accuracy of glanders diagnosis and establish an appropriate protocol in collaboration with the National Equine Health Program, seven horses positive for glanders kept in isolation in Brazil were examined fortnightly by CFT, microbiological screening, and molecular testing...
December 2020: Veterinary and Animal Science
Tim Keyes, Gale Ridge, Martha Klein, Nathan Phillips, Robert Ackley, Yufeng Yang
Leaked methane from natural gas distribution pipelines is a significant human and environmental health problem in urban areas. To assess this risk, urban mobile methane leak surveys were conducted, using innovative methodology, on the streets of Hartford, Danbury, and New London, Connecticut, in March 2019. The Hartford survey was done to determine if results from a 2016 survey (Keyes et al., 2019) were persistent, and surveys in additional towns were done to determine if similar findings could be made using an identical approach...
October 2020: Heliyon
Juliana D Klein, Aletta E Bester-van der Merwe, Matthew L Dicken, Arsalan Emami-Khoyi, Kolobe L Mmonwa, Peter R Teske
Knowledge about the demographic histories of natural populations helps to evaluate their conservation status, and potential impacts of natural and anthropogenic pressures. In particular, estimates of effective population size obtained through molecular data can provide useful information to guide management decisions for vulnerable populations. The spotted ragged-tooth shark, Carcharias taurus (also known as the sandtiger or grey nurse shark), is widely distributed in warm-temperate and subtropical waters, but has suffered severe population declines across much of its range as a result of overexploitation...
October 21, 2020: Scientific Reports
Katarzyna Januszewicz, Anita Cymann-Sachajdak, Paweł Kazimierski, Marek Klein, Justyna Łuczak, Monika Wilamowska-Zawłocka
In this work, we present the preparation and characterization of biomass-derived activated carbon (AC) in view of its application as electrode material for electrochemical capacitors. Porous carbons are prepared by pyrolysis of chestnut seeds and subsequent activation of the obtained biochar. We investigate here two activation methods, namely, physical by CO2 and chemical using KOH. Morphology, structure and specific surface area (SSA) of synthesized activated carbons are investigated by Brunauer-Emmett-Teller (BET) technique and scanning electron microscopy (SEM)...
October 19, 2020: Materials
Jacob J Visser, Stacy K Goergen, Stefan Klein, Teodoro Martín Noguerol, Perry J Pickhardt, Laura M Fayad, Patrick Omoumi
No abstract text is available yet for this article.
October 21, 2020: Seminars in Musculoskeletal Radiology
Eva-Katharina Willimsky, Anna Munzig, Karin Mayer, Saskia Biskup, Angela Abicht, Konstanze Hoertnagel, Hubertus von Voss, Hanns-Georg Klein, Imma Rost, Line H G Larsen, Hanns Atli Dahl, Hannes Hoelz, Celina von Stuelpnagel, Ingo Borggraefe
INTRODUCTION:  Next generation sequencing (NGS) with customized gene panels is a helpful tool to identify monogenic epilepsy syndromes. The number of genes tested within a customized panel may vary greatly. The aim of the present study was to compare the diagnostic yield of small (<25 kb) and large (>25 kb) customized epilepsy panels. METHODS:  This retrospective cohort study investigated data of 190 patients of 18 years or younger, with the diagnosis of an epilepsy of unknown etiology who underwent NGS using customized gene panels...
October 21, 2020: Neuropediatrics
Wallace Klein Schwengber, Laís Marques Mota, Carla Fernanda Nava, João Antônio Paim Rodrigues, André B Zanella, Ricardo De Souza Kuchenbecker, Rafael Selbach Scheffel, Ana Luiza Maia, Jose Miguel Dora
Objective: This study aimed to explore the patterns of radioactive iodine (RAI) use for differentiated thyroid cancer (DTC) in Brazil over the past 20 years. Methods: A retrospective analysis of the DTC-related RAI prescriptions, from 2000 to 2018, retrieved from the Department of Informatics of the Unified Health System (Datasus) and National Supplementary Health Agency (ANS) database was performed. RAI activities prescriptions were re-classified as low (30-50 mCi), intermediate (100 mCi), or high activities (>100 mCi)...
October 21, 2020: Archives of Endocrinology and Metabolism
Myung-Jae Hwang, Heung-Chul Kim, Terry A Klein, Sung-Tae Chong, Kisung Sim, Yeonseung Chung, Hae-Kwan Cheong
INTRODUCTION: A number of studies have been conducted on the relationship between the distribution of mosquito abundance and meteorological variables. However, few studies have specifically provided specific ranges of temperatures for estimating the maximum abundance of mosquitoes as an empirical basis for climatic dynamics for estimating mosquito-borne infectious disease risks. METHODS: Adult mosquitoes were collected for three consecutive nights/week using Mosquito Magnet® Independence® model traps during 2018 and 2019 at US Army Garrison (USAG) Humphreys, Pyeongtaek, Gyeonggi Province, Republic of Korea (ROK)...
2020: PloS One
Andrea Sanches, Vinicius Guzzoni, Vania C Dos R Miranda, Laís Bonagurio Peressim, Suellen Rocha, Patrícia Oliveira de Lima, Fernanda Klein Marcondes, Ana Paula Tanno, Tatiana Sousa Cunha
We investigated the effects of a recreational training (RET) protocol in elderly women with type-2 diabetes mellitus (T2DM). We hypothesized that non-conventional physical activities of RET protocol might improve clinical outcomes regarding cardiovascular function, metabolic profile and mental health as participants keep the adherence to the protocol during the 3-month follow-up. Cardiovascular parameters (heart rate, systolic and diastolic blood pressure), circulating biomarkers (glucose and lipids) and salivary cortisol were attenuated in response to exercise...
October 21, 2020: Health Care for Women International
M Kleine-König, H Rieger
No abstract text is available yet for this article.
October 21, 2020: Der Unfallchirurg
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