Asmaa Badr, Kylene P Daily, Mostafa Eltobgy, Shady Estfanous, Michelle H Tan, Jimmy Chun-Tien Kuo, Owen Whitham, Cierra Carafice, Gauruv Gupta, Heba M Amer, Mohamed M Shamseldin, Amir Yousif, Nicholas P Deems, Julie Fitzgerald, Pearlly Yan, Amy Webb, Xiaoli Zhang, Maciej Pietrzak, Hazem E Ghoneim, Purnima Dubey, Ruth M Barrientos, Robert J Lee, Olga N Kokiko-Cochran, Amal O Amer
Neuroinflammation and accumulation of Amyloid Beta (Aβ) accompanied by deterioration of special memory are hallmarks of Alzheimer's disease (AD). Effective preventative and treatment options for AD are still needed. Microglia in AD brains are characterized by elevated levels of microRNA-17 (miR-17), which is accompanied by defective autophagy, Aβ accumulation, and increased inflammatory cytokine production. However, the effect of targeting miR-17 on AD pathology and memory loss is not clear. To specifically inhibit miR-17 in microglia, we generated mannose-coated lipid nanoparticles (MLNPs) enclosing miR-17 antagomir (Anti-17 MLNPs), which are targeted to mannose receptors readily expressed on microglia...
May 6, 2024: Brain, Behavior, and Immunity