Clifford R Jack, Heather J Wiste, Alicia Algeciras-Schimnich, Stephen D Weigand, Dan J Figdore, Val J Lowe, Prashanthi Vemuri, Jonathan Graff-Radford, Vijay K Ramanan, David S Knopman, Michelle M Mielke, Mary M Machulda, Julie Fields, Christopher G Schwarz, Petrice M Cogswell, Matthew L Senjem, Terry M Therneau, Ronald C Petersen
BACKGROUND: We compared the ability of several plasma biomarkers versus amyloid positron emission tomography (PET) to predict rates of memory decline among cognitively unimpaired individuals. METHODS: We studied 645 Mayo Clinic Study of Aging participants. Predictor variables were age, sex, education, apolipoprotein E (APOE) ε4 genotype, amyloid PET, and plasma amyloid beta (Aβ)42/40, phosphorylated tau (p-tau)181, neurofilament light (NfL), glial fibrillary acidic protein (GFAP), and p-tau217...
January 24, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association