Nikolai Ratajczak, Ricardo Munoz-Acuna, Simone Redaelli, Aiman Suleiman, Eva-Lotte Seibold, Dario von Wedel, Denys Shay, Sarah Ashrafian, Guanqing Chen, Eswar Sundar, Elena Ahrens, Luca J Wachtendorf, Maximilian S Schaefer
BACKGROUND: Acetaminophen and 5-hydroxytryptamine-type-3 (5-HT3) receptor antagonists are administered as standard prophylaxes for postoperative pain, nausea, and vomiting. Preclinical studies however suggest that 5-HT3 antagonists may compromise acetaminophen's analgesic effect. This hospital registry study investigates whether 5-HT3 antagonists mitigate the analgesic effect of prophylactic acetaminophen in a perioperative setting. METHODS: This study included 55,016 adult patients undergoing general anesthesia for ambulatory procedures at a tertiary healthcare center in Massachusetts, United States of America, from 2015 to 2022...
May 3, 2024: Anesthesiology