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JOURNAL ARTICLE
Matthew S Perzanowski, Virginia Rauh, Bruce Ramphal, Luis Acosta, Lori Hoepner, Andrew G Rundle, Frederica P Perera, Julie Herbstman, Rachel L Miller, Amy E Margolis
Increased parasympathetic nervous system (PNS) activity is associated with attention-deficit/hyperactivity disorder (ADHD) inattentive symptoms, but not hyperactive-impulsive symptoms, and may contribute to inattentive subtype etiology. Guided by prior work linking infant rhinorrhea and watery eyes without a cold (RWWC) to PNS dysregulation, we examined associations between infant RWWC and childhood ADHD symptoms in a longitudinal cohort of Black and Latinx children living in the context of economic disadvantage (N = 301 youth: 158 females, 143 males)...
July 2024: Developmental Psychobiology
#2
JOURNAL ARTICLE
Minghui Tao, Yanping Zhang, Ling Ding, Donghong Peng
BACKGROUND: Sleep-disordered breathing (SDB) may lead to poor asthma control in children. OBJECTIVE: To identify risk factors of SDB in children with asthma and assess its impact on asthma control. METHODS: In this cross-sectional study, we collected data of outpatients with asthma at the Children's Hospital of Chongqing Medical University from June 2020 to August 2021. The Pediatric Sleep Questionnaire-Sleep-Related Breathing Disorder and the age-appropriate asthma control tests Childhood Asthma Control Test and Test for Respiratory and Asthma Control in Kids were completed...
April 30, 2024: BMC Pediatrics
#3
JOURNAL ARTICLE
Jingping Liu, Yujia Sun, Chunxin Tian, Dong Qin, Lanying Gao
Objective Allergic asthma (AA) is common in children. Excess copper is observed in AA patients. It is currently unclear whether copper imbalance can cause cuproptosis in pediatric AA. Methods The datasets about pediatric AA (GSE40732 and GSE40888) were obtained from Gene Expression Omnibus (GEO) database. The expression of cuproptosis-related genes (CRGs) and immune cell infiltration in pediatric AA samples were analyzed. Single-cell RNA sequencing (scRNA-seq) data (GSE193816) were used to evaluate the expression patterns of CRGs in AA...
April 30, 2024: Journal of Asthma
#4
JOURNAL ARTICLE
Xue Li, Juju Shang, Jian Liu, Yong Zhu
Background: This meta-analysis aimed to evaluate the effectiveness and adverse effects of specific immunotherapy (SIT) in the management of respiratory allergens, including allergic asthma, rhinitis, and related disorders, based on a review of current literature up to November 8, 2022. Methods: We conducted a search of databases, including PubMed, Embase, Cochrane, and Web of Science, to identify relevant randomized controlled trials (RCTs) assessing respiratory allergy-specific immunotherapy. We employed the Consolidated Standards of Reporting Trials (CONSORT) Statement to select RCTs that adhered to rigorous reporting standards...
April 30, 2024: Journal of Asthma
#5
JOURNAL ARTICLE
Sampo Kallio, Ching Jian, Katri Korpela, Anna Kaarina Kukkonen, Anne Salonen, Erkki Savilahti, Mikael Kuitunen, Willem M de Vos
Perinatal and early-life factors reported to affect risk of allergic diseases may be mediated by changes in the gut microbiota. Here, we explored the associations between the infant gut microbiota and allergic morbidity in childhood until 13 years of age in a subgroup of the FLORA probiotic intervention cohort. A mixture of four probiotic strains with galacto-oligosaccharides was administrated to the mothers from the 36th week of the pregnancy and later to their infants until 6 months of age. The infants were monitored for the manifestations of atopic eczema, food allergy, allergic rhinitis, and asthma by a pediatrician at 2 and 5 years of age; the allergic status was subsequently verified by a questionnaire at 10 and 13 years of age...
April 30, 2024: Microbiology Spectrum
#6
REVIEW
Deekshitha Alla, Dhruv Jayeshkumar Shah, Muneesh Seepana, Rishabh Baskara Salian, Sai Santhosha Mrudula Alla, Midhun Krishna Mohanan, Mert Sabıroğlu, Mohan Sai Sunith Vegesna, Aradhya Singh, Srajan Gupta, Shushrutha Shivalingappa Rekha
Objective. Commonly recommended drugs for adults and children include proton pump inhibitors (PPIs), proven effective for treating peptic diseases like stomach ulcers, GERD, and Helicobacter pylori infections in children over 1-year-old. Yet, prolonged PPI use carries higher risks of adverse reactions, prompting this study's analysis. Methods. We have performed a systematic review of 30 articles, which include a total of 762 505 pediatric patients. Results. Adverse effects were encountered in 6.98% of the population...
2024: Global Pediatric Health
#7
EDITORIAL
Mark L Levy, Louise Fleming, Andrew Bush
No abstract text is available yet for this article.
April 29, 2024: British Journal of General Practice
#8
JOURNAL ARTICLE
María Camila Guzmán, María de Vivero, Isabel Gil, Victoria Marrugo, Dilia Mercado, Josefina Zakzuk, Leonardo Puerta, Nathalie Acevedo, Luis Caraballo
OBJECTIVE: Determine the main asthma phenotypes in a population of asthmatic children in Cartagena, Colombia. METHODS: 107 children (7 to 17 years old) with a previous diagnosis of asthma were recruited. Biomarkers of T2 inflammation were evaluated by measuring FeNO, eosinophil count in peripheral blood by hemocytometry, and determination of specific IgE to mite allergens by ELISA. The study was approved by the ethics committee of the University of Cartagena (SGR, Grant BPIN2020000100405)...
February 1, 2024: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
#9
JOURNAL ARTICLE
Carlos E Barrios-Angulo, María Mónica de Vivero, Randy Reina-Rivero, María Camila Guzmán, Miguel Ángel Caballero, Nathalie Acevedo
OBJECTIVE: To carry out a preliminary analysis on the Treg lymphocyte counts present in the peripheral blood of allergic asthmatic children from the city of Cartagena, Colombia, compared to healthy controls. METHODS: We compared cytometry counts of ten asthmatic patients (age 7-16 years) and seven healthy controls (6-12 years), recruited in the city of Cartagena. Peripheral blood samples were stained using Cytek's 14-color cFluor Immunoprofiling kit (Cytek® cFluor® Immunoprofiling Kit 14 Color RUO kit), and analyzed on a Northern Lights™ spectral cytometer (Cytek® Biosciences, Fremont, CA, USA), to read 50...
February 1, 2024: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
#10
JOURNAL ARTICLE
Erika A Waters, Thorsten Pachur, Gabrielle Pogge, Jean Hunleth, Gregory D Webster, David A Fedele, James A Shepperd
OBJECTIVE: Pediatric asthma management is challenging for parents and guardians (hereafter caregivers ). We examined (1) how caregivers mentally represent trigger and symptom management strategies, and (2) how those mental representations are associated with actual management behavior. METHODS: In an online survey, N = 431 caregivers of children with asthma rated 20 trigger management behaviors and 20 symptom management behaviors across 15 characteristics, and indicated how often they engaged in each behavior...
April 29, 2024: Psychology & Health
#11
JOURNAL ARTICLE
Chuhan Cheng, Jing Lin, Zihan Zhang, Liyan Zhang
BACKGROUND: Asthma, characterized by recurrent wheezing, breathlessness, chest tightness, and coughing, is a major health concern among children and adolescents worldwide, currently affecting more than 5 million children. The increasing prevalence of obesity and overweight among the pediatric population has made the issue of childhood respiratory health more complex. Compared with children of healthy weight, the risk of asthma is higher in overweight and obese children. Zinc, a nutrient that regulates the oxidant-antioxidant balance, has been studied for its potential protective effects against asthma in adults and children...
May 2024: World Allergy Organization Journal
#12
JOURNAL ARTICLE
Baihua Xu, Lingqun Tang, Wenzhen Huang, Shubin Xie, Jiaxin Ye, Guiping Luo
INTRODUCTION: Allergic diseases are common chronic conditions in children, omalizumab has a wide range of adoptions in various diseases. A meta-analysis was implemented to demonstrate the efficacy of omalizumab in the therapy of pediatric allergic diseases. MATERIALS AND METHODS: English databases were searched. The search terms included "Omalizumab", "Children", "Allergic asthma", and "Atopic dermatitis". The literature was screened regarding inclusion and exclusion criteria, and data were extracted and analyzed using RevMan5...
April 30, 2024: Heliyon
#13
JOURNAL ARTICLE
Haijing Sui, Hong Shen, Chi Zhang, Minghui Wang, Zhen Zhen, Junbo Zhang
OBJECTIVE: This study aimed to explore whether saliva pepsin concentration (SPC) could be regarded as a risk factor for the occurrence and unfavorable control of asthma in children with allergic rhinitis. METHODS: A prospective study was conducted on a group of 20 consecutive children newly diagnosed with allergic rhinitis and asthma (referred to as the asthma group). All these children underwent fractional exhaled nitric oxide (FeNO) measurement, lung function tests, and assessment of asthma control using the 7-item Childhood Asthma Control Test (C-ACT) score...
2024: Journal of Asthma and Allergy
#14
JOURNAL ARTICLE
A G Adekanye, B C Onwughalu, R B Mgbe, Anu Umana, C O Anisi, A O Somefun
BACKGROUND: Predisposing factors for otitis media with effusion are multifactorial, ranging from genetic and anatomical abnormalities to environmental factors and inflammation of the nose and adjacent structures. AIM: The study determined the risk factors for otitis media with effusion (OME) among children in Calabar Municipality. METHODS: This was a descriptive, cross-sectional, community-based study including children aged 1-10 years randomly selected from government and privately owned daycares, nurseries (preschool), and primary schools...
April 1, 2024: Nigerian Journal of Clinical Practice
#15
JOURNAL ARTICLE
Analía Elizalde, Denise Hammer, Yan Su, Marilyn A Prasun
INTRODUCTION: One in four school-age children has a chronic health condition, with approximately 6% of them having multiple chronic health conditions. These students are at an elevated risk of individual health emergencies during school hours. While teachers receive online training to assist in these emergencies, they lack practicing with rescue medications. METHODS: We developed a Quality Improvement (QI) program that had a) a live presentation; b) a hands-on workshop to practice using rescue medications for allergies, asthma, seizures, and diabetes; c) fliers with first-aid guidelines; and d) a web-based reference toolkit...
April 27, 2024: Journal of Pediatric Nursing
#16
JOURNAL ARTICLE
Maria V Dimou, Paraskevi Xepapadaki, John Lakoumentas, Leonardos Mageiros, Xenophon Aggelidis, Maria Antonopoulou, Petros Bakakos, Sophia Βotskariova, Konstantinos Chliveros, Spyridon Chrysoulakis, Dionysios Dimas, Nikolaos Douladiris, Mina Gaga, Christos Grigoreas, Lampros Kalogiros, Michael Katotomichelakis, Evangelia Kompoti, Jannis Constantinidis, Zoi Koutsogianni, Stelios Loukides, Michael Makris, Emmanouil Manousakis, Pavlos Marangoudakis, Maria Marmara, Nikolaos Mikos, Paraskevi Mitsakou, Dimitrios Mitsias, Aris Pagalos, Vasilios Papanikolaou, Ioannis Paraskevopoulos, Constantinos Pitsios, Fotis Psarros, Nikoletta Rovina, Konstantinos Samitas, Evaggelia Stefanaki, Mina Vallianatou, Dimitrios Vourdas, Ioanna Tsiligianni, Jean Bousquet, Nikolaos G Papadopoulos
BACKGROUND: Allergic rhinitis (AR) is a common respiratory disease encompassing a variety of phenotypes. Patients can be sensitized to one or more allergens. There are indications that polysensitization is associated with more severe disease. However, the extent to which the level of sensitization is associated to clinical disease variability, underlying the distinct nature of AR from AR+ conjunctivitis or AR+ asthma, is not known. OBJECTIVE: The aim of this study was to evaluate phenotypical differences between mono- and poly-sensitized patients with AR and to quantify their symptomatic variability...
April 26, 2024: Annals of Allergy, Asthma & Immunology
#17
JOURNAL ARTICLE
Xiaosa Wen, Xinyue Zhang, Yun Qiu, Yaqin Wang, Liujie Zhu, Tao Liu, Zengliang Ruan
BACKGROUND: Little has been done to establish biobanks for studying the environment and lifestyle risk factors for diseases among the school-age children. The Minhang Pediatric Biobank (MPB) cohort study aims to identify factors associated with health and diseases of school-aged children living in the urban or suburban area of Shanghai. METHODS: This population-based cohort study was started in all sub-districts/towns of Minhang district of Shanghai in 2014. First-grade students in elementary school were enrolled during the time of their routine physical examinations, with self-administered questionnaires completed by their primary caregivers...
April 27, 2024: BMC Pediatrics
#18
JOURNAL ARTICLE
Xiongbin Chen, Peng Han, Yan Kong, Kunling Shen
BACKGROUND: Asthma is one of the most common chronic airway diseases in children. Preventing asthma exacerbation is one of the objectives of all asthma action plans. In patients with poor perception, it is difficult to identify acute asthma exacerbations by clinical asthma score, asthma control test or asthma control questionnaire. The aim of this study is to analyze whether children with asthma have changes in peak expiratory flow(PEF)before an acute asthma exacerbation and to evaluate the relationship between PEF and asthma exacerbation...
April 27, 2024: BMC Pediatrics
#19
JOURNAL ARTICLE
Robert Brinton Fujiki, Susan L Thibeault
PURPOSE: To determine the diagnostic utility of spirometry in distinguishing children with Induced Laryngeal Obstruction (ILO) or chronic non-specific cough (a.k.a. tic cough) from those with mild or moderate to severe asthma. METHODS: Retrospective cross sectional design. Children diagnosed with ILO (N = 70), chronic non-specific cough (N = 70), mild asthma (N = 60), or moderate to severe asthma (N = 60) were identified from the electronic medical record of a large children's hospital...
April 23, 2024: American Journal of Otolaryngology
#20
JOURNAL ARTICLE
Airin Veronese, Tina Uršič, Simona Bizjak Vojinovič, Jasna Rodman Berlot
Human metapneumovirus (hMPV) is an important pathogen that causes both upper (URTIs) and lower respiratory tract infections (LRTIs) in children. The virus can be implicated in severe bronchiolitis and pneumonia, necessitating hospitalization, with certain cases requiring intensive care unit intervention. As part of a retrospective observational study, we aimed to identify indicators of severe hMPV respiratory tract infections in children referred to the University Children's Hospital Ljubljana and the Department of Infectious Diseases Ljubljana, Slovenia, during a recent outbreak...
March 23, 2024: Microorganisms
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