Richard A Martirosian, Crystal D Wiedner, Jasmin Sanchez, Katherine T Mun, Kiran Marla, Cristina Teran, Marissa Thirion, David S Liebeskind, Emer R McGrath, Jared M Zucker, Rebecca Bernal, Alexa S Beiser, Charles DeCarli, Jayandra J Himali, Sudha Seshadri, Jason D Hinman
BACKGROUND: A coordinated network of circulating inflammatory molecules centered on the pleotropic pro-atherogenic cytokine interleukin-18 (IL-18) is linked to cerebral small vessel disease. We sought to validate the association of this inflammatory biomarker network with incident stroke risk, cognitive impairment, and imaging metrics in a sample of the Framingham Offspring Cohort. METHODS: Using available baseline measurements of serum levels of IL-18, GDF (growth and differentiation factor)-15, soluble form of receptor for advanced glycation end products, myeloperoxidase, and MCP-1 (monocyte chemoattractant protein-1) from Exam 7 of the Framingham Offspring Cohort (1998-2001), we constructed a population-normalized, equally weighted log-transformed mean Z -score value representing the average level of each serum analyte to create an inflammatory composite score (ICS5)...
May 1, 2024: Stroke; a Journal of Cerebral Circulation