Tatiana Gerashchenko, Rostislav Skitchenko, Anastasia Korobeynikova, Kristina Kuanysheva, Anna Khozyainova, Rostislav Vorobiev, Evgeny Rodionov, Sergey Miller, Evgeny Topolnitsky, Nikolay Shefer, Maxim Anisimenko, Lilia Zhuikova, Mrinal Vashisth, Olga Pankova, Vladimir Perelmuter, Valeria Rezapova, Mykyta Artomov, Evgeny Denisov
Early prediction and prevention of recurring illness is critical for improving the survival rates of patients with non-small cell lung cancer (NSCLC). Previously, we demonstrated that the presence of premalignant epithelial changes in the small bronchi distant to the primary tumor is associated with NSCLC progression: isolated basal cell hyperplasia (iBCH) indicates a high risk of distant metastasis, BCH combined with squamous metaplasia (BCHSM ) - a high risk of locoregional recurrence. Here, we aimed to identify germline single nucleotide variants (SNVs) and insertions and deletions (InDels) associated with distant metastasis and locoregional recurrence in cases with iBCH and BCHSM using whole-exome sequencing of 172 NSCLC patients...
April 24, 2024: Gene