keyword
https://read.qxmd.com/read/38672166/micrornas-in-atrial-fibrillation-mechanisms-vascular-implications-and-therapeutic-potential
#1
REVIEW
Emmanouil P Vardas, Panagiotis Theofilis, Evangelos Oikonomou, Panos E Vardas, Dimitris Tousoulis
Atrial fibrillation (AFib), the most prevalent arrhythmia in clinical practice, presents a growing global health concern, particularly with the aging population, as it is associated with devastating complications and an impaired quality of life. Its pathophysiology is multifactorial, including the pathways of fibrosis, inflammation, and oxidative stress. MicroRNAs (miRNAs), small non-coding RNA molecules, have emerged as substantial contributors in AFib pathophysiology, by affecting those pathways. In this review, we explore the intricate relationship between miRNAs and the aforementioned aspects of AFib, shedding light on the molecular pathways as well as the potential diagnostic applications...
April 6, 2024: Biomedicines
https://read.qxmd.com/read/38671440/culture-change-and-lessons-learned-from-ten-years-in-the-va-centers-of-excellence-in-primary-care-education
#2
JOURNAL ARTICLE
William G Weppner, Mamta K Singh, Joyce E Wipf, Rebecca Shunk, LeChauncy Woodard, Rebecca Brienza
BACKGROUND: Team-based care is critical to achieving health care value while maximizing patient outcomes. Few descriptions exist of graduate-level team training interventions and practice models. Experience from the multisite, decade-long Veterans Affairs (VA) Centers of Excellence in Primary Care Education provides lessons for developing internal medicine training experiences in interprofessional clinical learning environments. METHODS: A review of multisite demonstration project transforming traditional silo-model training to interprofessional team-based primary care...
April 26, 2024: BMC Medical Education
https://read.qxmd.com/read/38670415/multi-omics-data-integration-and-drug-screening-of-aml-cancer-using-generative-adversarial-network
#3
JOURNAL ARTICLE
Sabrin Afroz, Nadira Islam, Md Ahsan Habib, Md Selim Reza, Md Ashad Alam
In the era of precision medicine, accurate disease phenotype prediction for heterogeneous diseases, such as cancer, is emerging due to advanced technologies that link genotypes and phenotypes. However, it is difficult to integrate different types of biological data because they are so varied. In this study, we focused on predicting the traits of a blood cancer called Acute Myeloid Leukemia (AML) by combining different kinds of biological data. We used a recently developed method called Omics Generative Adversarial Network (GAN) to better classify cancer outcomes...
April 24, 2024: Methods: a Companion to Methods in Enzymology
https://read.qxmd.com/read/38669133/medical-malpractice-cases-involving-medical-students
#4
JOURNAL ARTICLE
Jordan R Pollock, Eric Shappell, Benjamin J Sandefur, M Lane Moore, Rachel A Lindor
PURPOSE: This study uses a large national legal database to analyze characteristics of malpractice claims involving U.S. medical students. METHOD: The Westlaw database was searched in September 2023 for malpractice cases involving medical students from January 1, 1900, through September 1, 2023. Each case was independently reviewed by 2 authors, abstracting each variable. Categorical data were summarized as frequency of occurrence (i.e., number and percentage), and continuous data were summarized with means, medians, and ranges...
April 25, 2024: Academic Medicine
https://read.qxmd.com/read/38669016/evacuation-and-health-care-outcomes-among-assisted-living-residents-after-hurricane-irma
#5
JOURNAL ARTICLE
Cassandra L Hua, Sweta Patel, Kali S Thomas, Dylan J Jester, Cyrus M Kosar, Lindsay J Peterson, Debra Dobbs, Ross Andel, David M Dosa
IMPORTANCE: Evacuation has been found to be associated with adverse outcomes among nursing home residents during hurricanes, but the outcomes for assisted living (AL) residents remain unknown. OBJECTIVE: To examine the association between evacuation and health care outcomes (ie, emergency department visits, hospitalizations, mortality, and nursing home visits) among Florida AL residents exposed to Hurricane Irma. DESIGN, SETTING, AND PARTICIPANTS: Retrospective cohort study using 2017 Medicare claims data...
April 1, 2024: JAMA Network Open
https://read.qxmd.com/read/38667115/understanding-spontaneous-symbolism-in-psychotherapy-using-embodied-thought
#6
JOURNAL ARTICLE
Erik Goodwyn
Spontaneous, unwilled subjective imagery and symbols (including dreams) often emerge in psychotherapy that can appear baffling and confound interpretation. Early psychoanalytic theories seemed to diverge as often as they agreed on the meaning of such content. Nevertheless, after reviewing key findings in the empirical science of spontaneous thought as well as insights gleaned from neuroscience and especially embodied cognition, it is now possible to construct a more coherent theory of interpretation that is clinically useful...
April 12, 2024: Behavioral Sciences
https://read.qxmd.com/read/38663498/emerging-applications-and-regulatory-strategies-for-advanced-medicines-manufacturing-towards-the-development-of-a-platform-approach
#7
REVIEW
Jagjit Singh Srai, Paul Bauer, Clive Badman, Massimo Bresciani, Charles L Cooney, Alastair Florence, Doug Hausner, Konstantin Konstantinov, Sau L Lee, Salvatore Mascia, Moheb Nasr, Bernhardt L Trout
The last decade has seen Advanced Medicines Manufacturing (AMM) progress from isolated product developments to the creation of industry-academic centres of excellence, regulatory innovation progressing leading to new standards, and product commercialisation across multiple product formats. This paper examines these developments focusing on successful applications and strategies presented at the 2023 Symposium of the International Consortium for Advanced Medicines Manufacturing (ICAMM). Despite these exemplar applications, there remain significant challenges to the sector-wide adoption of AMM technologies...
April 23, 2024: Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38663302/how-artificial-intelligence-could-transform-emergency-care
#8
REVIEW
Marika M Kachman, Irina Brennan, Jonathan J Oskvarek, Tayab Waseem, Jesse M Pines
Artificial intelligence (AI) in healthcare is the ability of a computer to perform tasks typically associated with clinical care (e.g. medical decision-making and documentation). AI will soon be integrated into an increasing number of healthcare applications, including elements of emergency department (ED) care. Here, we describe the basics of AI, various categories of its functions (including machine learning and natural language processing) and review emerging and potential future use-cases for emergency care...
April 16, 2024: American Journal of Emergency Medicine
https://read.qxmd.com/read/38661621/the-role-of-international-classification-of-diseases-10-codes-in-intimate-partner-violence-surveillance-examining-the-sensitivity-and-specificity-of-current-practice
#9
JOURNAL ARTICLE
May Shum, Dorothea Robertson, Caitlin Ryus, Gunjan Tiyyagura
No abstract text is available yet for this article.
April 24, 2024: Annals of Emergency Medicine
https://read.qxmd.com/read/38661226/emergency-department-documentation-of-legal-intervention-injuries-at-a-washington-dc-hospital
#10
JOURNAL ARTICLE
Kevin Xerxes Durgun, Neal Sikka, Kevin Davey, Colton Hood, Omair Khokhar, Alana Sadur, Monica Labine, Justin Zaslavsky
BACKGROUND: The U.S. Centers for Disease Control and Prevention (CDC) defines legal intervention injuries as injuries caused by law enforcement agents in the course of official duties. Public health databases utilize International Classification of Diseases, 10th Revision (ICD-10), coding to collect these data through the "Y35" family ICD-10 code. Prior studies report deficiencies in public health recording of fatal legal intervention injuries. Few studies have characterized nonfatal injuries...
April 25, 2024: Academic Emergency Medicine
https://read.qxmd.com/read/38661075/mental-illness-comorbidity-significantly-impacts-surgical-outcomes-for-emergency-surgical-patients
#11
JOURNAL ARTICLE
Kate E McBride, Judith Torzillo, Rebecca Davis, Daniel Steffens, Tim Wand, Robert D Sanders, Nick Glozier, Michael J Solomon
BACKGROUND: Whilst both mental illness comorbidity and the delivery of emergency surgery are commonplace in Australia, there is little evidence investigating any link between them. As such, this study examines the emergency surgical outcomes for patients with mental illness compared to other surgical patients within the Australian public surgical system. METHODS: Retrospective cohort study involving adult emergency and elective surgical patients treated at three public hospitals in Sydney, Australia between 2018 and 2019...
April 25, 2024: ANZ Journal of Surgery
https://read.qxmd.com/read/38659403/toward-identification-and-intervention-to-address-financial-toxicity-and-unmet-health-related-social-needs-among-adolescents-and-emerging-adults-with-cancer-and-their-caregivers-a-cross-cultural-perspective
#12
JOURNAL ARTICLE
Melissa P Beauchemin, Samrawit Solomon, Claudia L Michaels, Kathryn McHenry, Eleanor Turi, Rhea Khurana, Gabriella Sanabria
PURPOSE: We qualitatively explored the unique needs and preferences for financial toxicity screening and interventions to address financial toxicity among adolescents and emerging adults (younger AYAs: 15-25 years) with cancer and their caregivers. METHODS: We recruited English- or Spanish-speaking younger AYAs who were treated for cancer within the past 2 years and their caregivers. Semi-structured interviews were conducted to explore preferences for screening and interventional study development to address financial toxicity...
April 2024: Cancer Medicine
https://read.qxmd.com/read/38658837/identifying-mitigation-strategies-of-comprehensive-health-centers-against-dust-hazard-a-qualitative-study-in-iran
#13
JOURNAL ARTICLE
Arezoo Sarani, Asghar Tavan, Kambiz Bahaadinbeigy, Mohsen Aminzadeh, Seyed Mobin Moradi, Gholamreza Khademipour, Hojjat Farahmandnia
BACKGROUND: Exposure to dust can disrupt healthcare services and severely affect all activity domains of the health system. The aim of this study was to explore mitigation strategies for comprehensive health centers against dust hazard. METHOD: The present study was conducted using a qualitative design with a conventional content analysis approach in 2023. The participants in this study were managers and staff of comprehensive health centers and experts in health in disasters and emergencies in Kerman, Bam, Regan, and Ahvaz...
April 24, 2024: BMC Emergency Medicine
https://read.qxmd.com/read/38657387/radiographers-experiences-in-working-with-patients-living-with-dementia-in-norway-a-qualitative-study
#14
JOURNAL ARTICLE
E Kjelle, C Eikefet, C C Chilanga
INTRODUCTION: Imaging departments are seeing an increase in the number of patients living with dementia (PWD), driven by the ageing population and diagnostic benefits offered by medical imaging. This study explored radiographers' experiences during imaging examinations for PWD. METHODS: A semi-structured interview guide comprising questions about radiographers' experiences, knowledge concerning PWD, challenges faced, and departmental initiatives was developed. Eight radiographers were interviewed, four working in MRI or general imaging, including CT and four in nuclear medicine, at three hospital trusts in Norway...
April 23, 2024: Radiography
https://read.qxmd.com/read/38656577/accuracy-of-influenza-icd-10-diagnosis-codes-in-identifying-influenza-illness-in-children
#15
JOURNAL ARTICLE
James W Antoon, Tess Stopczynski, Justin Z Amarin, Laura S Stewart, Julie A Boom, Leila C Sahni, Marian G Michaels, John V Williams, Janet A Englund, Eileen J Klein, Mary A Staat, Elizabeth P Schlaudecker, Rangaraj Selvarangan, Jennifer E Schuster, Geoffrey A Weinberg, Peter G Szilagyi, Ariana Perez, Heidi L Moline, Andrew J Spieker, Carlos G Grijalva, Samantha M Olson, Natasha B Halasa
IMPORTANCE: Studies of influenza in children commonly rely on coded diagnoses, yet the ability of International Classification of Diseases, Ninth Revision codes to identify influenza in the emergency department (ED) and hospital is highly variable. The accuracy of newer International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) codes to identify influenza in children is unknown. OBJECTIVE: To determine the accuracy of ICD-10 influenza discharge diagnosis codes in the pediatric ED and inpatient settings...
April 1, 2024: JAMA Network Open
https://read.qxmd.com/read/38653129/rna-mediated-epigenetic-regulation-in-exercised-heart-mechanisms-and-opportunities-for-intervention
#16
JOURNAL ARTICLE
Lijun Wang, Wensi Wan, Shuang Zhang, Tarun Keswani, Guoping Li, Junjie Xiao
Physical exercise has been widely acknowledged as a beneficial lifestyle alteration and a potent non-pharmacological treatment for heart disease. Extensive investigations have revealed the beneficial effects of exercise on the heart and the underlying mechanisms involved. Exercise is considered one of the key factors that can lead to epigenetic alterations. The increasing number of identified molecules in the exercised heart has led to many studies in recent years that have explored the cellular function of ncRNAs and RNA modifications in the heart...
April 22, 2024: Molecular Aspects of Medicine
https://read.qxmd.com/read/38653064/deepseq2drug-an-expandable-ensemble-end-to-end-anti-viral-drug-repurposing-benchmark-framework-by-multi-modal-embeddings-and-transfer-learning
#17
JOURNAL ARTICLE
Weidun Xie, Jixiang Yu, Lei Huang, Lek Shyuen For, Zetian Zheng, Xingjian Chen, Yuchen Wang, Zhichao Liu, Chengbin Peng, Ka-Chun Wong
Drug repurposing is promising in multiple scenarios, such as emerging viral outbreak controls and cost reductions of drug discovery. Traditional graph-based drug repurposing methods are limited to fast, large-scale virtual screens, as they constrain the counts for drugs and targets and fail to predict novel viruses or drugs. Moreover, though deep learning has been proposed for drug repurposing, only a few methods have been used, including a group of pre-trained deep learning models for embedding generation and transfer learning...
April 17, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38649124/circrna-cdr1as-affects-functional-repair-after-spinal-cord-injury-and-regulates-fibrosis-through-the-smad-pathway
#18
JOURNAL ARTICLE
Wenzhao Wang, Chang Liu, Dong He, Guidong Shi, Ping Song, Boqing Zhang, Tian Li, Jianlu Wei, Yunpeng Jiang, Liang Ma
Spinal cord injury (SCI) is a complex problem in modern medicine. Fibroblast activation and fibroscarring after SCI impede nerve recovery. Non-coding RNA plays an important role in the progression of many diseases, but the study of its role in the progression of spinal fibrosis is still emerging. Here, we investigated the function of circular RNAs, specifically antisense to the cerebellar degeneration-related protein 1 (CDR1as), in spinal fibrosis and characterized its molecular mechanism and pathophysiology...
April 20, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38648293/signs-sources-coping-strategies-and-suggested-interventions-for-burnout-among-preclerkship-students-at-a-u-s-medical-school-a-qualitative-focus-group-study
#19
JOURNAL ARTICLE
Valeria D Melo, Hiba Saifuddin, Lillian T Peng, Alexandra P Wolanskyj-Spinner, Ariela L Marshall, Andrea N Leep Hunderfund
PURPOSE: Research suggests that burnout can begin early in medical school, yet burnout among preclerkship students remains underexplored. This study aimed to characterize burnout signs, sources, coping strategies, and potential interventions among preclerkship students at one U.S. medical school. METHOD: The authors conducted a qualitative study of preclerkship students at Mayo Clinic Alix School of Medicine (MCASOM) during June 2019. Participants completed 2 Maslach Burnout Inventory (MBI) items (measuring frequency of emotional exhaustion and depersonalization) and 2 free-text questions on burnout before participating in 1 of 3 semistructured focus groups...
April 22, 2024: Academic Medicine
https://read.qxmd.com/read/38646001/the-stigma-of-burnout-impeding-formal-help-a-qualitative-study%C3%A2-exploring-residents-experiences-during-training
#20
JOURNAL ARTICLE
Lemmese Alwatban, Mai S Alageel, Lina A Alshehri, Norah Saud Alfehaid, Reem Abdullah Albahlal, Norah Hejji Almazrou, Raghad Almubarak
PURPOSE: Burnout is an occupational stress syndrome that gives rise to emotional exhaustion (EE) depersonalization (DP) and reduced personal accomplishment (PA). Increasing rates of burnout among health care professionals has been reported globally. Saudi Arabia appears to be among the highest in prevalence with reports of higher than 70%. Medical residents in training are the highest group at risk. The literature has repeatedly linked burnout among residents with poor academic performance on training exams, impaired quality of life, career choice regret and intentions to abandon medicine...
2024: Advances in Medical Education and Practice
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