Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
EDITORIAL
Gerson Alves Pereira Júnior, Ramiro Colleoni Neto, Leonardo Emilio Silva, Luiz Carlos VON Bahten, César Eduardo Fernandes, Pedro Eder Portari-Filho
Medical societies must maintain high standards of competence and quality when awarding specialist titles, defining the certification criteria, taking into account the needs and realities of the health system and medical practice.
2024: Revista do Colégio Brasileiro de Cirurgiões
#2
JOURNAL ARTICLE
Gerson Alves Pereira Júnior, Pedro Tadao Hamamoto-Filho, Roberto Rasslan, Dyego Sá Benevenuto, Eduardo Nacur Silva, Alexandre Ferreira Oliveira, Pedro Eder Portari Filho
The article discusses the evolution of the Brazilian College of Surgeons (CBC) specialist title exam, highlighting the importance of evaluating not only theoretical knowledge, but also the practical skills and ethical behavior of candidates. The test was instituted in 1971, initially with only the written phase, and later included the oral practical test, starting with the 13th edition in 1988. In 2022, the assessment process was improved by including the use of simulated stations in the practical test, with the aim of assessing practical and communication skills, as well as clinical reasoning, in order to guarantee excellence in the assessment of surgeons training...
2024: Revista do Colégio Brasileiro de Cirurgiões
#3
REVIEW
Gerson N Moreno Romero, Avery R Twyman, Maria F Bandres, Jacob Graves McPherson
Electrical stimulation of spinal neurons has emerged as a valuable tool to enhance rehabilitation after spinal cord injury. In separate parameterizations, it has shown promise for improving voluntary movement, reducing symptoms of autonomic dysreflexia, improving functions mediated by muscles of the pelvic floor (e.g., bowel, bladder, and sexual function), reducing spasms and spasticity, and decreasing neuropathic pain, among others. This diverse set of actions is related both to the density of sensorimotor neural networks in the spinal cord and to the intrinsic ability of electrical stimulation to modulate neural transmission in multiple spinal networks simultaneously...
May 15, 2024: Bioelectronic Medicine
#4
JOURNAL ARTICLE
Rahul S Bhansali, Fredrik Ellin, Thomas Relander, Miao Cao, Wenrui Li, Qi Long, Nivetha Ganesan, Robert N Stuver, Steven M Horwitz, Kitsada Wudhikarn, Steven R Hwang, N Nora Bennani, Julio C Chavez, Lubomir Sokol, Hayder Saeed, Frank Duan, Pierluigi Porcu, Priyanka Pullarkat, Neha Mehta-Shah, Jasmine Zain, Miguel Ruiz, Jonathan E Brammer, Rishab Prakash, Swaminathan Padmanabhan Iyer, Adam J Olszewski, Ajay Major, Peter A Riedell, Sonali M Smith, Caroline Goldin, Bradley M Haverkos, Bei Hu, Tony Z Zhuang, Pamela Blair Allen, Wael Toama, Murali Janakiram, Deepa Jagadeesh, Taylor R Brooks, Nisha Hariharan, Aaron Michael Goodman, Gabrielle Hartmann, Paola Ghione, Fatima Fayyaz, Joanna M Rhodes, Elise A Chong, James N Gerson, Daniel J Landsburg, Sunita D Nasta, Stephen J Schuster, Jakub Svoboda, Mats Jerkeman, Stefan K Barta
Little is known about risk factors for central nervous system (CNS) relapse in mature T- and NK-cell neoplasms (MTNKN). We aimed to describe the clinical epidemiology of CNS relapse in patients with MTNKN and developed the CNS relapse In T-cell lymphoma Index (CITI) to predict patients at highest risk of CNS relapse. We reviewed data from 135 patients with MTNKN and CNS relapse from 19 North American institutions. After exclusion of leukemic and most cutaneous forms of MTNKN, patients were pooled with non-CNS relapse control patients from a single institution to create a CNS relapse-enriched training set...
May 13, 2024: Blood Advances
#5
JOURNAL ARTICLE
Mariana Oliveira-Silva, Rafael Silva Goulart, Miguel Augusto Moraes, Rafael Nakamura-Silva, Rodrigo Yudi Fujimoto, Ricardo Coelho Sousa, Renata Katsuko Takayama Kobayashi, Leonardo Pinto Medeiros, Gerson Nakazato, André Pitondo-Silva
Escherichia coli is one of the key bacteria responsible for a variety of diseases in humans and livestock-associated infections around the globe. It is the leading cause of mortality in neonatal and weaned piglets in pig husbandry, causing diarrhea and significant harm to the industry. Furthermore, the frequent and intensive use of antimicrobials for the prevention of diseases, particularly gastrointestinal diseases, may promote the selection of multidrug-resistant (MDR) strains. These resistant genotypes can be transmitted through the excrement of animals, including swine...
May 10, 2024: Environmental Monitoring and Assessment
#6
JOURNAL ARTICLE
Min Peng, Gerson D Keppeke, Li-Kuang Tsai, Chia-Chun Chang, Ji-Long Liu, Li-Ying Sung
The cytoophidium is an evolutionarily conserved subcellular structure formed by filamentous polymers of metabolic enzymes. In vertebrates, inosine monophosphate dehydrogenase (IMPDH), which catalyses the rate-limiting step in guanosine triphosphate (GTP) biosynthesis, is one of the best-known cytoophidium-forming enzymes. Formation of the cytoophidium has been proposed to alleviate the inhibition of IMPDH, thereby facilitating GTP production to support the rapid proliferation of certain cell types such as lymphocytes, cancer cells and pluripotent stem cells (PSCs)...
May 8, 2024: Cellular and Molecular Life Sciences: CMLS
#7
JOURNAL ARTICLE
Fernando Xavier, Gerson Laurindo Barbosa, Cristiano Corrêa de Azevedo Marques, Antonio Mauro Saraiva
OBJECTIVE: This study aims to integrate the concepts of planetary health and big data into the Donabedian model to evaluate the Brazilian dengue control program in the state of São Paulo. METHODS: Data science methods were used to integrate and analyze dengue-related data, adding context to the structure and outcome components of the Donabedian model. This data, considering the period from 2010 to 2019, was collected from sources such as Department of Informatics of the Unified Health System (DATASUS), the Brazilian Institute of Geography and Statistics (IBGE), WorldClim, and MapBiomas...
2024: Revista de Saúde Pública
#8
JOURNAL ARTICLE
Marília Costa Paiva, Antonio A M Castro, Polyagna Ferreira Carvalho, Weslley Barbosa Sales, Isabelly Cristina Soares Oliveira, Maryela Neves Mourão, Álvaro Campos Cavalcanti Maciel, Gérson Fonseca Souza
Cardiovascular diseases are the leading cause of mortality worldwide, requiring support to manage symptoms and improve prognosis. Home-based cardiac rehabilitation is a realistic resource for this purpose, but it requires patients' self-management skills in order to change behaviours. Smartphones are considered mHealth technology (mobile technological resources in healthcare) and have the potential to provide modalities for delivery of cardiac rehabilitation. This systematic review aims to examine these modalities and identify those that are most effective for improving exercise capacity, quality of life, and patient compliance...
April 2024: CJC open
#9
JOURNAL ARTICLE
Kent Andrew Q Tuble, Christine Joy M Omisol, Gerson Y Abilay, Tomas Ralph B Tomon, Blessy Joy M Aguinid, Gerard G Dumancas, Roberto M Malaluan, Arnold A Lubguban
Cellulosic substrates, including wood and thatch, have become icons for sustainable architecture and construction, however, they suffer from high flammability because of their inherent cellulosic composition. Current control measures for such hazards include applying intumescent fire-retardant (IFR) coatings that swell and form a char layer upon ignition, protecting the underlying substrate from burning. Typically, conventional IFR coatings are opaque and are made of halogenated compounds that release toxic fumes when ignited, compromising the roofing's aesthetic value and sustainability...
May 2, 2024: Chemosphere
#10
JOURNAL ARTICLE
Ingrid Soares Garcia, Bárbara Silva-Vignato, Aline Silva Mello Cesar, Juliana Petrini, Vinicius Henrique da Silva, Natália Silva Morosini, Carolina Purcell Goes, Juliana Afonso, Thaís Ribeiro da Silva, Beatriz Delcarme Lima, Luan Gaspar Clemente, Luciana Correia de Almeida Regitano, Gerson Barreto Mourão, Luiz Lehmann Coutinho
Intramuscular fat (IMF) and backfat thickness (BFT) are critical economic traits impacting meat quality. However, the genetic variants controlling these traits need to be better understood. To advance knowledge in this area, we integrated RNA-seq and single nucleotide polymorphisms (SNPs) identified in genomic and transcriptomic data to generate a linkage disequilibrium filtered panel of 553,581 variants. Expression quantitative trait loci (eQTL) analysis revealed 36,916 cis-eQTLs and 14,408 trans-eQTLs. Association analysis resulted in three eQTLs associated with BFT and 24 with IMF...
May 2, 2024: Scientific Reports
#11
JOURNAL ARTICLE
Gerson Oliveira Penna, Maria Araci de Andrade Pontes, Sinésio Talhari, Heitor de Sá Gonçalves, Carolina Chrusciak Tonalhari Cortez, Allen de Souza Pessoa, Valderiza Pedroza, Samira Bührer-Sékula, Mariane Martins de Araujo Stefani, Maria Lucia Fernandes Penna
BACKGROUND: Leprosy is a neglected dermato-neurologic, infectious disease caused by Mycobacterium leprae or M. lepromatosis. Leprosy is treatable and curable by multidrug therapy/MDT, consisting of 12 months rifampicin, dapsone and clofazimine for multibacillary/MB patients and for 6 months for paucibacillary/PB patients. The relapse rate is considered a crucial treatment outcome. A randomized Controlled Trial (U-MDT/CT-BR) conducted from 2007‒2012 compared clinical outcomes in MB patients after 12 months regular MDT/R-MDT and 6 months uniform MDT/U-MDT in two highly endemic Brazilian areas...
April 29, 2024: Brazilian Journal of Infectious Diseases
#12
COMPARATIVE STUDY
Gerson Gatass Orro de Campos, Leandro Steinhorst Goelzer, Tiago Rodrigues de Lemos Augusto, Gisele Walter Barbosa, Gaspar R Chiappa, Erik H van Iterson, Paulo T Muller
BACKGROUND: Currently, excess ventilation has been grounded under the relationship between minute-ventilation/carbon dioxide output ( V ˙ E - V ˙ CO 2 ). Alternatively, a new approach for ventilatory efficiency ( η E V ˙ ) has been published. OBJECTIVE: Our main hypothesis is that comparatively low levels of η E V ˙ between chronic heart failure (CHF) and chronic obstructive pulmonary disease (COPD) are attainable for a similar level of maximum and submaximal aerobic performance, conversely to long-established methods ( V ˙ E - V ˙ CO 2 slope and intercept)...
2024: Arquivos Brasileiros de Cardiologia
#13
JOURNAL ARTICLE
Ana Carolina Cestari Bighetti, Tania Mary Cestari, Suelen Paini, Karina T Pomini, Daniela Vieira Buchaim, Rafael Carneiro Ortiz, Rui Seabra Ferreira Júnior, Benedito Barraviera, Izabel R F R Bullen, Gustavo Pompermaier Garlet, Rogério Leone Buchaim, Gerson F de Assis
AIM: To assess the efficacy of heterologous fibrin biopolymer (HFB) in promoting alveolar bone healing after tooth extraction in rats. MATERIALS AND METHODS: The upper right incisors of 48 Wistar rats were extracted. Toothless sockets were filled with HFB (HFBG, n = 24) or blood clot (BCG, n = 24). The tooth extraction sites were subjected to micro-computed tomography (micro-CT), histological, histomorphometric and immunohistochemical (for Runt-related transcription factor 2/Runx2 and tartrate-resistant acid phosphatase/TRAP) analyses on days 0, 7, 14 and 42 after extraction...
April 29, 2024: Journal of Clinical Periodontology
#14
JOURNAL ARTICLE
Fredy Armando A Aguilar, Rafael S C Barone, Gerson B Mourão, Luiz Antonio Martinelli, José Eurico P Cyrino
Piaractus mesopotamicus, is a fish usually farmed in semi-intensive systems with access to natural food and supplementary feed. This study evaluates effects of feed allowance on the productive performance, carbon turnover and proportions of nutrient (carbon) contribution of feed and natural food for the growth of pacu. Juvenile fish were stocked in fiberglass tanks and fed to 100, 75, 50, 25, 0% apparent satiety (ApS), with a practical, extruded (C4 photosynthetic pathway) feed in a randomized design trial (n=3); plankton production for simulated semi-intensive farming system condition was induced by chemical fertilization...
2024: Anais da Academia Brasileira de Ciências
#15
JOURNAL ARTICLE
Juliana Goulart Prata Oliveira Milani, Mauricio Milani, Felipe Vilaça Cavallari Machado, Matthias Wilhelm, Thimo Marcin, Flavio D'Ascenzi, Luna Cavigli, Charly Keytsman, Maarten Falter, Bruno Bonnechere, Raf Meesen, Fabrício Braga, Graziella França Bernardelli Cipriano, Veronique Cornelissen, Kenneth Verboven, Gerson Cipriano Junior, Dominique Hansen
AIMS: To develop and validate equations predicting heart rate (HR) at the first and second ventilatory thresholds (VTs) and an optimized range-adjusted prescription for patients with cardiometabolic disease (CMD). To compare their performance against guideline-based exercise intensity domains. METHODS: Cross-sectional study involving 2,868 CMD patients from nine countries. HR predictive equations for first and second VTs (VT1, VT2) were developed using multivariate linear regression with 975 cycle-ergometer cardiopulmonary exercise tests (CPET)...
April 18, 2024: European Journal of Preventive Cardiology
#16
JOURNAL ARTICLE
Ana Carla Batissoco, Dayane Bernardino Cruz, Thiago Geronimo Pires Alegria, Gerson Kobayashi, Jeanne Oiticica, Luis Eduardo Soares Netto, Maria Rita Passos-Bueno, Luciana Amaral Haddad, Regina Célia Mingroni Netto
Pathogenic DNA alterations in GJB2 are present in nearly half of non-syndromic hearing loss cases with autosomal recessive inheritance. The most frequent variant in GJB2 causing non-syndromic hearing loss is the frameshifting c.35del. GJB2 encodes Cx26, a protein of the connexin family that assembles hemichannels and gap junctions. The expression of paralogous proteins is believed to compensate for the loss of function of specific connexins. As Cx26 has been involved in cell differentiation in distinct tissues, we employed stem cells derived from human exfoliated deciduous teeth (SHEDs), homozygous for the c...
2024: Genetics and Molecular Biology
#17
JOURNAL ARTICLE
Diego Giulliano Destro Christofaro, William R Tebar, Jorge Mota, Leandro D Delfino, Amanda B Santos, Raphael M Ritti-Dias, Rômulo A Fernandes, Gerson Ferrari, Luiz Carlos M Vanderlei
BACKGROUND: Practicing sports during childhood and adolescence provides benefits to cardiac autonomic modulation (CAM) at these stages of life. However, it is not known whether these benefits to CAM persist into adulthood. Therefore, the objective of this study was to analyze the association of early sports practice (sports practice in childhood and/or adolescence) with CAM in adult life, regardless of habitual moderate-to-vigorous PA. METHODS: The sample of the present study consisted of 242 adults (141 women and 101 men; age: 41...
April 16, 2024: Sports Medicine—Open
#18
JOURNAL ARTICLE
Clênia Oliveira Araújo, Carla Cristina Araújo Alves, Francisco R A Santos, Lawrence P Cahalin, Graziella França Bernardelli Cipriano, Gerson Cipriano
OBJECTIVE: This study aimed to determine the effects of inspiratory muscle training (IMT) on exercise capacity, respiratory muscle strength, length of hospital stay (LOS), and quality of life (QOL) following coronary artery bypass graft surgery. METHODS: The search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and the Cochrane Handbook and included the databases MEDLINE, EMBASE, CINAHL, Scopus, and CENTRAL...
April 16, 2024: Physical Therapy
#19
JOURNAL ARTICLE
Kaio Maciel de Santiago-Silva, Priscila Goes Camargo, Larissa Esteves Carvalho Constant, Stephany da Silva Costa, Giovanna Barbosa Frensel, Diego Allonso, Gerson Nakazato, Camilo Henrique da Silva Lima, Marcelle de Lima Ferreira Bispo
Scientists and researchers have been searching for drugs targeting the main protease (Mpro) of SARS-CoV-2, which is crucial for virus replication. This study employed a virtual screening based on molecular docking to identify benzoylguanidines from an in-house chemical library that can inhibit Mpro on the active site and three allosteric sites. Molecular docking was performed on the LaSMMed Chemical Library using 88 benzoylguanidine compounds. Based on their RMSD values and conserved pose, three potential inhibitors (BZG1, BZG2, and BZG3) were selected...
April 14, 2024: Scientific Reports
#20
JOURNAL ARTICLE
Rima Maslauskiene, Ruta Vaiciuniene, Peteris Tretjakovs, Gita Gersone, Aurelija Radzeviciene, Andrejus Bura, Edgaras Stankevicius, Inga Arune Bumblyte
With an increasing number of marginal donors, additional methods for the evaluation of cadaveric kidney quality are required. This study aimed to evaluate pretransplant deceased donor serum (s) and urine (u) biomarkers, including neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), interleukin-18, and C-X-C motif chemokine 10 (CXCL10) for predicting early and late graft function. In total, 43 deceased kidney donors and 76 corresponding recipients were enrolled. Delayed graft function (DGF) occurred in 27...
March 28, 2024: Diagnostics
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
