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EDITORIAL
Lydia Su Yin Wong, Ayobami Akenroye, Philippe Eigenmann, Elizabeth Huiwen Tham
No abstract text is available yet for this article.
May 2024: Pediatric Allergy and Immunology
#2
JOURNAL ARTICLE
Isabel Fernandez, Fabien Touzot
BACKGROUND: Autoimmune lymphoproliferative syndrome (ALPS) is a rare primary immune disorder caused by defect of the extrinsic apoptotic pathway. The current diagnostic criteria combine clinical features and typical biomarkers but have not been the object of clear international consensus. METHODS: We conducted a retrospective study on pediatric patients who were investigated for autoimmune cytopenia and/or lymphoproliferation at the CHU Sainte-Justine Hospital over 10 years...
May 2024: Pediatric Allergy and Immunology
#3
JOURNAL ARTICLE
Sonia Ares-Gómez, Narmeen Mallah, Jacobo Pardo-Seco, Alberto Malvar-Pintos, Olaia Pérez-Martínez, María-Teresa Otero-Barrós, Nuria Súarez-Gaiche, Maria-Isolina Santiago-Pérez, Juan-Manuel González-Pérez, Luis-Ricardo López-Pérez, Benigno Rosón, Rosa-María Alvárez-Gil, Olga-María Ces-Ozores, Victoria Nartallo-Penas, Susana Mirás-Carballal, Carmen Rodríguez-Tenreiro, Irene Rivero-Calle, Antonio Salas, Carmen Durán-Parrondo, Federico Martinón-Torres
BACKGROUND: The morbidity burden of respiratory syncytial virus (RSV) in infants extends beyond hospitalization. Defining the RSV burden before implementing prophylaxis programs is essential for evaluating any potential impact on short- to mid-term morbidity and the utilization of primary healthcare (PHC) and emergency services (ES). We established this reference data using a population-based cohort approach. METHODS: Infants hospitalized for RSV from January 2016 to March 2023 were matched with non-hospitalized ones based on birthdate and sex...
May 2024: Pediatric Allergy and Immunology
#4
JOURNAL ARTICLE
Punita Ponda, Jane E Cerise, Brianne Navetta-Modrov, Jamie Kiehm, Grace M Covelli, Jared Weiss, Annette T Lee
BACKGROUND: Immune regulation by gut microbiota is affected by dysbiosis and may precede food allergy onset. Prior studies lack comparisons stratified by age and clinical phenotype. OBJECTIVE: The primary objective was to assess the microbiome of children with food allergy (< 3years, 3-18years) compared to similar aged children without food allergy. METHODS: A real-world prospective cross-sectional study performed from 2014-2019 recruited children highly likely to have milk, egg or peanut allergy defined by history and serum IgE or confirmed by food challenge...
April 30, 2024: Annals of Allergy, Asthma & Immunology
#5
REVIEW
Camille Braun, Laurianne Coutier, Philippe Bégin, Audrey Nosbaum
While the early introduction of food allergens in the infant diet has been shown to be effective at preventing the development of food allergy (FA), its implementation in real life has been associated with various challenges. Interventions aimed at correcting skin barrier dysfunction have been explored in recent decades as a distinct or complementary mean to prevent allergic sensitization through the skin and subsequent development of FA. Studies assessing the application of emollient from birth have yielded conflicting results, and meta-analyses have demonstrated either no effect or only a slight positive effect on FA prevention...
May 2024: Pediatric Allergy and Immunology
#6
JOURNAL ARTICLE
Katie Ray, David Vyles, Tracy Zembles, Michelle Mitchell
No abstract text is available yet for this article.
April 29, 2024: Journal of Allergy and Clinical Immunology in Practice
#7
JOURNAL ARTICLE
Josefin Ullberg, Disa Ullberg, Mareike Fech-Bormann, Ulrika L Fagerberg
BACKGROUND: Food protein-induced enterocolitis syndrome (FPIES), a non-immunoglobulin E (IgE)-mediated allergy, primarily affects infants and young children. Whether and when tolerance develops seems to vary among populations and trigger foods. OBJECTIVE: This study aimed to evaluate tolerance development and its assessment in a Swedish cohort. METHODS: This was a prospective follow-up study of a Swedish cohort of 113 children, followed at 25 pediatric departments, with acute FPIES...
April 27, 2024: Journal of Allergy and Clinical Immunology in Practice
#8
JOURNAL ARTICLE
Cynthia Haddad, Ankona Banerjee, Joshua Eubanks, Ruchit Rana, Nicholas L Rider, Lisa Pompeii, Sara Anvari
BACKGROUND: Food protein-induced enterocolitis syndrome (FPIES) is being increasingly recognized as a non-IgE mediated food allergy; however, it remains unclear if and how the presentation, diagnosis and management of this disease has changed in recent years. OBJECTIVE: To reappraise the FPIES cohort at a large United States pediatric tertiary referral center. METHODS: We performed a retrospective chart review of pediatric FPIES patients (ICD-10: K52...
April 27, 2024: Journal of Allergy and Clinical Immunology in Practice
#9
JOURNAL ARTICLE
Courtney Hoskinson, Maria V Medeleanu, Myrtha E Reyna, Darlene Ly Dai, Biswajit Chowdhury, Theo J Moraes, Piushkumar J Mandhane, Elinor Simons, Anita L Kozyrskyj, Meghan B Azad, Charisse Petersen, Stuart E Turvey, Padmaja Subbarao
BACKGROUND: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in both pediatric and adult populations. The development of AD has been linked to antibiotic usage, which causes perturbation of the microbiome and has been associated with abnormal immune system function. However, imbalances in the gut microbiome itself associated with antibiotic usage have been inconsistently linked to AD. OBJECTIVE: This study aimed to elucidate the timing and specific factors mediating the relationship between systemic (oral or intravenous) antibiotic usage and AD...
April 24, 2024: Journal of Allergy and Clinical Immunology
#10
REVIEW
Nikolaos G Papadopoulos, Adnan Custovic, Antoine Deschildre, James E Gern, Antonio Nieto Garcia, Michael Miligkos, Wanda Phipatanakul, Gary Wong, Paraskevi Xepapadaki, Ioana Agache, Stefania Arasi, Zeinab Awad El-Sayed, Leonard B Bacharier, Matteo Bonini, Fulvio Braido, Davide Caimmi, Jose A Castro-Rodriguez, Zhimin Chen, Michael Clausen, Timothy Craig, Zuzana Diamant, Francine M Ducharme, Motohiro Ebisawa, Philippe Eigenmann, Wojciech Feleszko, Vincezo Fierro, Alessandro Fiocchi, Luis Garcia-Marcos, Anne Goh, René Maximiliano Gómez, Maia Gotua, Eckard Hamelmann, Gunilla Hedlin, Elham M Hossny, Zhanat Ispayeva, Daniel J Jackson, Tuomas Jartti, Miloš Jeseňák, Omer Kalayci, Alan Kaplan, Jon R Konradsen, Piotr Kuna, Susanne Lau, Peter Le Souef, Robert F Lemanske, Michael Levin, Mika J Makela, Alexander G Mathioudakis, Oleksandr Mazulov, Mário Morais-Almeida, Clare Murray, Karthik Nagaraju, Zoltan Novak, Ruby Pawankar, Marielle W Pijnenburg, Helena Pite, Paulo M Pitrez, Petr Pohunek, David Price, Alfred Priftanji, Valeria Ramiconi, Daniela Rivero Yeverino, Graham Roberts, Aziz Sheikh, Kun-Ling Shen, Zsolt Szepfalusi, Ioanna Tsiligianni, Mirjana Turkalj, Steve Turner, Tetiana Umanets, Arunas Valiulis, Susanne Vijveberg, Jiu-Yao Wang, Tonya Winders, Dong Keon Yon, Osman M Yusuf, Heather J Zar
Monitoring is a major component of asthma management in children. Regular monitoring allows for diagnosis confirmation, treatment optimization, and natural history review. Numerous factors that may affect disease activity and patient well-being need to be monitored: response and adherence to treatment, disease control, disease progression, comorbidities, quality of life, medication side-effects, allergen and irritant exposures, diet and more. However, the prioritization of such factors and the selection of relevant assessment tools is an unmet need...
April 2024: Pediatric Allergy and Immunology
#11
JOURNAL ARTICLE
Jacqueline Wong, Adelle Atkinson, Kathryn Timberlake, Carolyn E Beck, Bryan Maguire, Michelle Science
OBJECTIVE: To evaluate the implementation of an antimicrobial stewardship programme-led inpatient beta-lactam allergy de-labelling programme using a direct oral provocation test (OPT). DESIGN: One-year quality improvement study using a before-after design. SETTING: Free-standing tertiary care paediatric hospital. PATIENTS: Patients with a reported beta-lactam allergy admitted to the paediatric medicine inpatient unit...
April 25, 2024: Archives of Disease in Childhood
#12
JOURNAL ARTICLE
Aada Murtomäki, Alma Helevä, Paulus Torkki, Jari Haukka, Anna Julkunen-Iivari, Riikka Lemmetyinen, Mika Mäkelä, Aarno Dietz, Mikko Nuutinen, Sanna Toppila-Salmi
BACKGROUND: Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the nose and paranasal sinuses lasting ≥12 weeks. CRS may exist with (CRSwNP) or without (CRSsNP) nasal polyps. The aim was to evaluate conditions associated with CRS in a randomized hospital cohort. We hypothesized that comorbidities and surgical procedures differ between pediatric and adult patients. METHODS: This study consisted of hospital registry data of a random sample of rhinosinusitis patients (age range 0-89 years) with the diagnosis of J32 or J33, correspondingly, registered during outpatient visits from 2005 to 2019 (n = 1461)...
April 2024: Clinical and Translational Allergy
#13
REVIEW
Christopher M Warren, Tami R Bartell
A large and growing corpus of epidemiologic studies suggests that the population-level burden of pediatric FA is not equitably distributed across major sociodemographic groups, including race, ethnicity, household income, parental educational attainment, and sex. As is the case for more extensively studied allergic disease states such as asthma and atopic dermatitis epidemiologic data suggest that FA may be more prevalent among certain populations experiencing lower socioeconomic status (SES), particularly those with specific racial and ethnic minority backgrounds living in highly urbanized regions...
April 2024: Pediatric Allergy and Immunology
#14
JOURNAL ARTICLE
Ellen Daily Stephen, Sven Wang, Manali Shah, Anandu Dileep, Shannon Manz, Niki Mirhosseini, Mahboobeh Mahdavinia
BACKGROUND: Atopic dermatitis (AD) is a known risk factor for the development of food allergy. Prior work has suggested disparities in diagnosis/management of food allergy in urban populations. OBJECTIVE: We aimed to determine whether socioeconomic conditions, as measured by the Area Deprivation Index (ADI) and insurance status, or racial/ethnic self-identity were associated with risk of food allergy diagnosis (DFA), evaluation by an allergist, or objective food allergy testing among high-risk children with atopic dermatitis...
April 20, 2024: Annals of Allergy, Asthma & Immunology
#15
REVIEW
Simone Foti Randazzese, Ilenia Panasiti, Lucia Caminiti, Francesco Catamerò, Massimo Landi, Maria De Filippo, Martina Votto, Roberta Olcese, Filippo Favuzza, Mattia Giovannini, Salvatore Barberi
Peanut allergy affects about 1%-3% of the pediatric population in the world, with an important increase in the last decades. Nowadays, international guidelines recommend the early introduction of peanuts in the infant diet, with poor information about the quantity and the frequency of the intake. Allergen immunotherapy may represent the only therapeutic strategy able to modify the natural history of peanut allergy. In particular, oral immunotherapy showed the most promising results in terms of efficacy, but with significant rates of adverse reactions, mostly gastrointestinal...
April 2024: Pediatric Allergy and Immunology
#16
EDITORIAL
Javier S Cabrera-Perez, Philippe Eigenmann, Ayobami Akenroye
No abstract text is available yet for this article.
April 2024: Pediatric Allergy and Immunology
#17
JOURNAL ARTICLE
Takako Suzuki, Yoshitaka Sato, Yusuke Okuno, Yuka Torii, Yuto Fukuda, Kazunori Haruta, Makoto Yamaguchi, Yoshiki Kawamura, Asahito Hama, Atsushi Narita, Hideki Muramatsu, Tetsushi Yoshikawa, Yoshiyuki Takahashi, Hiroshi Kimura, Yoshinori Ito, Jun-Ichi Kawada
Epstein-Barr virus (EBV) infection can lead to infectious mononucleosis (EBV-IM) and, more rarely, EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH), which is characterized by a life-threatening hyperinflammatory cytokine storm with immune dysregulation. Interferon-gamma (IFNγ) has been identified as a critical mediator for primary HLH; however, the detailed role of IFNγ and other cytokines in EBV-HLH is not fully understood. In this study, we used single-cell RNA sequencing to characterize the immune landscape of EBV-HLH and compared it with EBV-IM...
April 20, 2024: Journal of Clinical Immunology
#18
REVIEW
Marisa A Ryan, Anna Ermarth
Gastroesophageal reflux (GER) and eosinophilic esophagitis (EoE) are the most common inflammatory causes of pediatric dysphagia, but several other less prevalent conditions should be considered. These conditions can affect one or several aspects of the swallowing process. In some inflammatory conditions dysphagia may be an early symptom. Esophagoscopy and instrumental swallow studies are often needed to determine the underlying diagnosis and best treatment plan. In some inflammatory conditions dysphagia can portend a worse outcome and need for more aggressive treatment of the underlying condition...
April 17, 2024: Otolaryngologic Clinics of North America
#19
JOURNAL ARTICLE
Devangi Shah, Jeffrey M Chambliss, Rory E Nicolaides, Timothy G Chow
No abstract text is available yet for this article.
April 16, 2024: Journal of Allergy and Clinical Immunology in Practice
#20
JOURNAL ARTICLE
Raed Alzyoud, Motasem Alsuweiti, Heba Maaitah, Boshra Aladaileh, Mohammed Noubani, Hamazh Nsour
PURPOSE: Inborn errors of immunity (IEI) are a heterogeneous group of diseases with variable clinical phenotypes. This study was conducted to describe the epidemiology, clinical presentations, treatment, and outcome of IEI in Jordanian children. METHODS: A retrospective data analysis was conducted for children under 15 years diagnosed with IEI from the pediatric Allergy, Immunology, and Rheumatology Division-based registry at Queen Rania Children's Hospital, Amman, Jordan, between 2010 and 2022...
April 17, 2024: Journal of Clinical Immunology
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