keyword
https://read.qxmd.com/read/33098468/covid-19-in-parkinson-s-disease-what-holds-the-key
#1
R Sainz-Amo, B Baena-Álvarez, I Pareés, G Sánchez-Díez, P Pérez-Torre, J L López-Sendón, S Fanjul-Arbos, E Monreal, I Corral-Corral, N García-Barragán, J C Martínez-Castrillo, A Fasano, A Alonso-Cánovas
INTRODUCTION: Parkinson's disease (PD) is more frequent in the elderly and increases the risk of respiratory infections. Previous data on PD and SARS-CoV-2 are scarce, suggesting a poor prognosis in advanced disease and second-line therapies. METHODS: A retrospective case-control study comparing patients with PD and COVID-19 and patients with PD without COVID-19 was conducted during the pandemic period in Spain (March 1st-July 31st 2020) in a tertiary university hospital...
October 24, 2020: Journal of Neurology
https://read.qxmd.com/read/33098318/relation-between-anticholinergic-burden-and-cognitive-impairment-results-from-the-monzino-80-plus-population-based-study
#2
Luca Pasina, Ugo Lucca, Mauro Tettamanti
PURPOSE: We examined data collected in the Monzino 80-plus study to assess the relations between cognitive performance and ACB scores according to the hypothesis that a higher anticholinergic burden is associated with reduced cognitive performance. METHODS: The Monzino 80-plus is an ongoing, prospective, door-to-door population-based study started in 2002 among all residents 80 years or older in eight municipalities of Varese province, Italy. To establish the relation between cognitive impairment and the anticholinergic drug burden we recorded the ACB score for each patient at baseline...
October 24, 2020: Pharmacoepidemiology and Drug Safety
https://read.qxmd.com/read/33098308/retinal-thickness-predicts-the-risk-of-cognitive-decline-in-parkinson-s-disease
#3
Ane Murueta-Goyena, Rocío Del Pino, Marta Galdós, Begoña Arana, Marian Acera, Mar Carmona-Abellán, Tamara Fernández-Valle, Beatriz Tijero, Olaia Lucas-Jiménez, Natalia Ojeda, Naroa Ibarretxe-Bilbao, Javier Peña, Jesus Cortes, Unai Ayala, Maitane Barrenechea, Juan Carlos Gómez-Esteban, Iñigo Gabilondo
OBJECTIVE: To analyze longitudinal changes of retinal thickness and their predictive value as biomarkers of disease progression in idiopathic Parkinson's disease (iPD). METHODS: Patients with Lewy body diseases (LBDs) were enrolled and prospectively evaluated at 3 years, including patients with iPD (n=42), dementia with Lewy bodies (DLB, n=4), E46K-SNCA mutation carriers (n=4) and controls (n=17). All participants underwent Spectralis retinal optical coherence tomography and Montreal Cognitive Assessment (MoCA), and Unified Parkinson's Disease Rating Scale (UPDRS) score was obtained in patients...
October 24, 2020: Annals of Neurology
https://read.qxmd.com/read/33098213/increased-risk-of-incident-dementia-following-use-of-anticholinergic-agents-a-systematic-literature-review-and-meta-analysis
#4
REVIEW
Roger R Dmochowski, Sydney Thai, Kristy Iglay, Ekene Enemchukwu, Silvia Tee, Susann Varano, Cynthia Girman, Larry Radican, Paul N Mudd, Charles Poole
BACKGROUND/RATIONALE: Long-term treatment with anticholinergic agents may increase the risk of cognitive impairment or dementia. This systematic literature review and meta-analysis aimed to assess the impact of ≥3 months of exposure to anticholinergics as a class on the risk of dementia, mild cognitive impairment, and change in cognitive function. The impact of anticholinergic agents specifically used to treat overactive bladder was also evaluated. MATERIALS AND METHODS: A systematic literature review was conducted to identify English language articles evaluating the impact of anticholinergic use for ≥3 months on dementia or cognitive function in adult patients...
October 23, 2020: Neurourology and Urodynamics
https://read.qxmd.com/read/33098137/reframing-dementia-nursing-students-relational-learning-with-rather-than-about-people-with-dementia-a-constructivist-grounded-theory-study
#5
Wendy Grosvenor, Ann Gallagher, Sube Banerjee
OBJECTIVES: Developing an informed and effective workforce that provides effective and ethical care to people with dementia and their families is an international priority. Here we explore the impact of a novel approach on students of adult nursing. It involved engagement with people with dementia and their carers over three years in the Time for Dementia Programme. This research explored students' perceptions of their professional learning and practice. METHODS: A longitudinal, constructivist grounded theory approach in three phases (three years) was used...
October 23, 2020: International Journal of Geriatric Psychiatry
https://read.qxmd.com/read/33098031/underscreening-and-undertreatment-periodontal-service-provision-in-very-old-germans
#6
Joachim Krois, Aleksander Krasowski, Jesus Gomez Rossi, Sebastian Paris, Adelheid Kuhlmey, Hendrik Meyer-Lückel, Falk Schwendicke
OBJECTIVES: We aimed to assess periodontal services utilization in very old Germans. METHODS: A comprehensive sample of very old (≥ 75 years), insured at a large Northeastern statutory insurer was followed over 6 years (2012-2017). We assessed periodontal service provision, entailing (1) periodontal screening index (PSI), (2) periodontal status/treatment planning, (3) periodontal therapy (scaling and root planning with or without access surgery), (4) postoperative reevaluation, and (5) any of these four services groups...
October 23, 2020: Clinical Oral Investigations
https://read.qxmd.com/read/33098004/risk-factors-for-dislocation-after-bipolar-hemiarthroplasty-a-retrospective-case-control-study-of-patients-with-ct-data
#7
Tilman Graulich, Pascal Graeff, Ashish Jaiman, Stine Nicolaides, Tarek Omar Pacha, Marcus Örgel, Christian Macke, Mohamed Omar, Christian Krettek, Emmanouil Liodakis
PURPOSE: Bipolar hemiarthroplasty has been shown to have a lower rate of dislocation than total hip arthroplasty. However, as the influencing risk factors for bipolar hemiarthroplasty dislocation remain unclear, we aimed to analyse patient and surgeon-specific influencing risk factors for bipolar hemiarthroplasty dislocation. METHODS: We retrospectively analysed patients who were operated between 2012 and 2018 and had dislocated bipolar hemiarthroplasty and matched them to patients without a dislocated bipolar hemiarthroplasty, operated between 2018 and 2019...
October 23, 2020: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://read.qxmd.com/read/33097764/reduced-striatal-vesicular-monoamine-transporter-2-in-rem-sleep-behavior-disorder-imaging-prodromal-parkinsonism
#8
Leah C Beauchamp, Victor L Villemagne, David I Finkelstein, Vincent Doré, Ashley I Bush, Kevin J Barnham, Christopher C Rowe
Motor deficits in parkinsonism are caused by degeneration of dopaminergic nigral neurons. The success of disease-modifying therapies relies on early detection of the underlying pathological process, leading to early interventions in the disease phenotype. Healthy (n = 16), REM sleep behavior disorder (RBD) (n = 14), dementia with Lewy bodies (n = 10), and Parkinson's disease (PD) (n = 20) participants underwent 18 F-AV133 vesicular monoamine transporter type-2 (VMAT2) PET to determine the integrity of the nigrostriatal pathway...
October 23, 2020: Scientific Reports
https://read.qxmd.com/read/33097630/principal-components-analysis-based-measures-of-pet-data-closely-reflect-neuropathological-staging-schemes
#9
Ganna Blazhenets, Lars Frings, Arnd Sörensen, Philipp T Meyer
Voxel-based principal components analysis allows for an identification of patterns of glucose metabolism and amyloid deposition related to the conversion from mild cognitive impairment (MCI) to Alzheimer's dementia (ADCRP). Present study aimed to validate these ADCRPs against neuropathological findings. Methods We included patients from the Alzheimer's disease (AD) neuroimaging initiative who underwent autopsy and for whom 18 F-FDG [30 AD dementia, 6 MCI, 2 cognitively normal (CN)] and amyloid-beta (Aβ) [17 AD dementia, 3 MCI, 2 CN] PET were available...
October 23, 2020: Journal of Nuclear Medicine
https://read.qxmd.com/read/33097601/dementia-and-epilepsy-not-a-one-way-street
#10
EDITORIAL
W Allen Hauser, Alberto Lleo, Heike Schmolck
No abstract text is available yet for this article.
October 23, 2020: Neurology
https://read.qxmd.com/read/33097599/the-bi-directional-association-between-epilepsy-and-dementia-the-framingham-heart-study
#11
Maria Stefanidou, Alexa S Beiser, Jayandra Jung Himali, Teng J Peng, Orrin Devinsky, Sudha Seshadri, Daniel Friedman
OBJECTIVES: To assess the risk of incident epilepsy among participants with prevalent dementia, and the risk of incident dementia among participants with prevalent epilepsy in the Framingham Heart Study (FHS) . METHODS: We analyzed prospectively collected data in the Original and Offspring FHS cohorts. To determine the risk of developing epilepsy among participants with dementia and the risk of developing dementia among participants with epilepsy we used separate, nested, case-control designs and matched each case to 3 age-, sex- and FHS cohort-matched controls...
October 23, 2020: Neurology
https://read.qxmd.com/read/33097597/dementia-in-late-onset-epilepsy-the-atherosclerosis-risk-in-communities-study
#12
Emily L Johnson, Gregory L Krauss, Anna Kucharska-Newton, Marilyn S Albert, Jason Brandt, Keenan A Walker, Sevil Yasar, David S Knopman, Keith A Vossel, Rebecca F Gottesman
OBJECTIVE: To determine the risk of dementia after the development of late-onset epilepsy. METHODS: We used data from the Atherosclerosis Risk in Communities (ARIC) cohort study, which started in 1987-1989 with 15,792 mostly black and white men and women from 4 U.S. communities. We identified late-onset epilepsy (LOE; seizures starting at age 67 or later) from linked Medicare claims data. We used a Cox proportional hazards regression model to evaluate associations between LOE and dementia through 2017 as ascertained from neuropsychological testing, interviews, and hospital discharge surveillance; and we used multinomial logistic regression to assess the risk of dementia and mild cognitive impairment in the subset with full neuropsychological assessments available...
October 23, 2020: Neurology
https://read.qxmd.com/read/33097556/chip-mutations-affect-the-heat-shock-response-differently-in-human-fibroblasts-and-ipsc-derived-neurons
#13
S Schuster, E Heuten, A Velic, J Admard, M Synofzik, S Ossowski, B Macek, S Hauser, L Schöls
C-terminus of HSC70-interacting protein (CHIP) encoded by the gene STUB1 is a co-chaperone and E3 ligase that acts as a key regulator of cellular protein homeostasis. Mutations in STUB1 cause autosomal recessive spinocerebellar ataxia type 16 (SCAR16) with widespread neurodegeneration manifesting as spastic-ataxic gait disorder, dementia and epilepsy. CHIP-/- mice display severe cerebellar atrophy, show high perinatal lethality and impaired heat stress tolerance. To decipher the pathomechanism underlying SCAR16, we investigated the heat shock response (HSR) in primary fibroblasts of three SCAR16 patients...
October 12, 2020: Disease Models & Mechanisms
https://read.qxmd.com/read/33097389/stroke-risk-among-elderly-users-of-haloperidol-and-typical-antipsychotics-versus-atypical-antipsychotics-a-real-world-study-from-a-us-health-insurance-claims-database
#14
Daniel Fife, Clair Blacketer, R Karl Knight, James Weaver
BACKGROUND: We estimated stroke risk associated with new exposure to haloperidol, or any typical antipsychotic, versus atypical antipsychotic among patients aged ≥65 years regardless of dementia status. METHODS: IBM MarketScan Medicare Supplemental Database data (January 1, 2001 to December 31, 2017) were used. Stroke risk for new users of typical antipsychotics (T1 cohort) or haloperidol (T2 cohort) was compared with new users of atypical antipsychotics (C1 cohort) aged ≥65 years...
September 28, 2020: American Journal of Geriatric Psychiatry
https://read.qxmd.com/read/33096998/fingerfoods-a-feasibility-study-to-enhance-fruit-and-vegetable-consumption-in-dutch-patients-with-dementia-in-a-nursing-home
#15
Annemijn Visscher, Marieke C E Battjes-Fries, Ondine van de Rest, Olga N Patijn, Mascha van der Lee, Nienke Wijma-Idsinga, Gerda K Pot, Peter Voshol
BACKGROUND: Eating problems are highly prevalent in older patients with dementia and as a consequence, these patients are at greater risk of becoming malnourished. Fingerfoods, snacks that can be picked with thumb and forefinger, could be used to counteract malnutrition in patients with dementia. The aim of this feasibility study was to evaluate whether providing fruit and vegetable rich fingerfoods in the form of recognizable and familiar snacks on top of the normal intake was feasible for both patients with dementia and caregivers as a means to increase patients' nutritional status...
October 23, 2020: BMC Geriatrics
https://read.qxmd.com/read/33096909/ganglion-cell-layer-thinning-in-alzheimer-s-disease
#16
REVIEW
Alicia López-de-Eguileta, Andrea Cerveró, Ainara Ruiz de Sabando, Pascual Sánchez-Juan, Alfonso Casado
The main advantages of optical retinal imaging may allow researchers to achieve deeper analysis of retinal ganglion cells (GC) in vivo using optical coherence tomography (OCT). Using this device to elucidate the impact of Alzheimer's disease (AD) on retinal health with the aim to identify a new AD biomarker, a large amount of studies has analyzed GC in different stages of the disease. Our review highlights recent knowledge into measuring retinal morphology in AD making distinctive between whether those studies included patients with clinical dementia stage or also mild cognitive impairment (MCI), which selection criteria were applied to diagnosed patients included, and which device of OCT was employed...
October 21, 2020: Medicina
https://read.qxmd.com/read/33096655/alpha-synuclein-in-alcohol-use-disorder-connections-with-parkinson-s-disease-and-potential-therapeutic-role-of-5-untranslated-region-directed-small-molecules
#17
REVIEW
Catherine M Cahill, Rozaleen Aleyadeh, Jin Gao, Changning Wang, Jack T Rogers
Alpha-synuclein (α-Syn) is a 140-amino acid (aa) protein encoded by the Synuclein alpha SNCA gene. It is the synaptic protein associated with Parkinson's disease (PD) and is the most highly expressed protein in the Lewy bodies associated with PD and other alpha synucleopathies, including Lewy body dementia (LBD) and multiple system atrophy (MSA). Iron deposits are present in the core of Lewy bodies, and there are reports suggesting that divalent metal ions including Cu2+ and Fe2+ enhance the aggregation of α-Syn...
October 21, 2020: Biomolecules
https://read.qxmd.com/read/33091783/delirium-diagnostic-tool-provisional-ddt-pro-scores-in-delirium-subsyndromal-delirium-and-no-delirium
#18
José G Franco, Paula T Trzepacz, Esteban Sepúlveda, María V Ocampo, Juan D Velásquez-Tirado, Daniel R Zaraza, Cristóbal Restrepo, Alejandra M Giraldo, Paola A Serna, Adolfo Zuluaga, Carolina López
OBJECTIVE: To evaluate whether the Delirium Diagnostic Tool-Provisional (DDT-Pro), a 0-9 point scale with three items each representing symptoms from delirium's three core domains, differentiates subsyndromal delirium (SSD) from delirium and no delirium. METHODS: We applied cluster analyses of DDT-Pro scores from 200 consecutive inpatients using three reference standards for delirium diagnosis to determine DDT-Pro cutoff values for delirium, SSD and no delirium groups...
October 13, 2020: General Hospital Psychiatry
https://read.qxmd.com/read/33091750/genetic-and-nongenetic-factors-associated-with-cadasil-a-retrospective-cohort-study
#19
Carolina Ospina, Joseph F Arboleda-Velasquez, Daniel Camilo Aguirre-Acevedo, Yesica Zuluaga-Castaño, Lina Velilla, Gloria P Garcia, Yakeel T Quiroz, Francisco Lopera
OBJECTIVE: To explore the role of cardiovascular risk factors and the different NOTCH-3 mutations to explain the variability observed in the clinical presentation of CADASIL. METHODS: This was a retrospective cohort study of 331 individuals, 90 were carriers of four mutations in the NOTCH3 gene. These four mutations are the ones identified in our region from the genetic evaluation of probands. Cox proportional hazards models were fitted to estimate the effect of genetic and cardiovascular factors on the onset of migraine, first stroke, and dementia...
October 13, 2020: Journal of the Neurological Sciences
https://read.qxmd.com/read/33091740/predicting-the-progression-of-mild-cognitive-impairment-using-machine-learning-a-systematic-quantitative-and-critical-review
#20
Manon Ansart, Stéphane Epelbaum, Giulia Bassignana, Alexandre Bône, Simona Bottani, Tiziana Cattai, Raphaël Couronné, Johann Faouzi, Igor Koval, Maxime Louis, Elina Thibeau-Sutre, Junhao Wen, Adam Wild, Ninon Burgos, Didier Dormont, Olivier Colliot, Stanley Durrleman
We performed a systematic review of studies focusing on the automatic prediction of the progression of mild cognitive impairment to Alzheimer's disease (AD) dementia, and a quantitative analysis of the methodological choices impacting performance. This review included 172 articles, from which 234 experiments were extracted. For each of them, we reported the used data set, the feature types, the algorithm type, performance and potential methodological issues. The impact of these characteristics on the performance was evaluated using a multivariate mixed effect linear regressions...
October 6, 2020: Medical Image Analysis
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