Jessica Nicolazzo, Katharine Xu, Alexandra Lavale, Rachel Buckley, Nawaf Yassi, Garun S Hamilton, Paul Maruff, Andree-Ann Baril, Yen Ying Lim, Matthew P Pase
STUDY OBJECTIVES: To examine if sleep symptomatology was associated with subjective cognitive concerns or objective cognitive performance in a dementia-free community-based sample. METHODS: A total of 1421 middle-aged participants (mean±standard deviation = 57±7; 77% female) from the Healthy Brain Project completed the Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), and Epworth Sleepiness Scale (ESS) to measure sleep quality, insomnia symptom severity, and daytime sleepiness, respectively...
April 10, 2021: Sleep
Susan B Roberts, Rachel E Silver, Sai Krupa Das, Roger A Fielding, Cheryl H Gilhooly, Paul F Jacques, Jennifer M Kelly, Joel B Mason, Nicola M McKeown, Meaghan A Reardon, Sheldon Rowan, Edward Saltzman, Barbara Shukitt-Hale, Caren E Smith, Allen A Taylor, Dayong Wu, Fang Fang Zhang, Karen Panetta, Sarah Booth
The amount of time spent in poor health at the end of life is increasing. This narrative review summarizes consistent evidence indicating that healthy dietary patterns and maintenance of a healthy weight in the years leading to old age are associated with broad prevention of all the archetypal diseases and impairments associated with aging including: noncommunicable diseases, sarcopenia, cognitive decline and dementia, osteoporosis, age-related macular degeneration, diabetic retinopathy, hearing loss, obstructive sleep apnea, urinary incontinence, and constipation...
April 10, 2021: Advances in Nutrition
Karen Bluth, Christine Lathren, Johanna V T Silbersack Hickey, Sheryl Zimmerman, Christopher J Wretman, Philip D Sloane
BACKGROUND/OBJECTIVES: Certified nursing assistants (CNAs) who work in nursing homes (NHs) face significant work and personal stress. Self-compassion training has been shown to decrease stress postintervention in previous studies among healthcare providers and those in helping professions. This study examines the feasibility, acceptability, and preliminary outcomes of self-compassion training to address CNA stress and well-being. DESIGN: Pre-post intervention. SETTING: Three mid-size, nonprofit NHs in North Carolina...
April 10, 2021: Journal of the American Geriatrics Society
Lauren B Gerlach, Shekinah Fashaw, Julie Strominger, Jessica Ogarek, Andrew R Zullo, Lori A Daiello, Joan Teno, Theresa I Shireman, Julie P W Bynum
IMPORTANCE: The Centers for Medicare & Medicaid Services' (CMS) National Partnership to Improve Dementia Care in Nursing Homes ("CMS National Partnership") focuses on reducing antipsychotic prescribing to long-term care residents. Hospice enrollment is not an exclusionary condition for the antipsychotic quality measure reported by CMS. It is unclear how prescribing in hospice may have been impacted by the initiative. OBJECTIVE: Estimate the association of the CMS National Partnership with trends in antipsychotic prescribing among long-term care residents in hospice...
April 9, 2021: Journal of the American Geriatrics Society
Narinder Kapur, Steven Kemp, Gus Baker
No abstract text is available yet for this article.
April 10, 2021: Brain
Sungyang Jo, Seon-Ok Kim, Kye Won Park, Seung Hyun Lee, Yun Su Hwang, Sun Ju Chung
We aimed to investigate the role of the APOE genotype in cognitive and motor trajectories in Parkinson's disease (PD). Using PD registry data, we retrospectively investigated a total of 253 patients with PD who underwent the Mini-Mental State Exam (MMSE) two or more times at least 5 years apart, were aged over 40 years, and free of dementia at the time of enrollment. We performed group-based trajectory modeling to identify patterns of cognitive change using the MMSE. Kaplan-Meier survival analysis was used to investigate the role of the APOE genotype in cognitive and motor progression...
April 9, 2021: Scientific Reports
Vincenzo Donadio, Zerui Wang, Alex Incensi, Giovanni Rizzo, Enrico Fileccia, Veria Vacchiano, Sabina Capellari, Martina Magnani, Cesa Scaglione, Michelangelo Stanzani Maserati, Patrizia Avoni, Rocco Liguori, Wenquan Zou
OBJECTIVE: To determine whether: 1) the immunofluorescence (IF) is a reproducible technique in detecting misfolded α-synuclein (α-syn) in skin nerves; and subsequently 2) IF and RT-QuIC (both in skin and CSF) show a comparable in vivo diagnostic accuracy in distinguish synucleinopathies (SOPs) from non-synucleinopathies (non-SOPs) in a large cohort of patients. METHODS: We prospectively recruited 90 patients fulfilling clinical and instrumental diagnostic criteria for all SOPs variants and non-SOPs (mainly including Alzheimer disease, tauopathies, and vascular parkinsonism or dementia)...
April 9, 2021: Neurology
Laura Fumagalli, Florence L Young, Steven Boeynaems, Mathias De Decker, Arpan R Mehta, Ann Swijsen, Raheem Fazal, Wenting Guo, Matthieu Moisse, Jimmy Beckers, Lieselot Dedeene, Bhuvaneish T Selvaraj, Tijs Vandoorne, Vanesa Madan, Marka van Blitterswijk, Denitza Raitcheva, Alexander McCampbell, Koen Poesen, Aaron D Gitler, Philipp Koch, Pieter Vanden Berghe, Dietmar Rudolf Thal, Catherine Verfaillie, Siddharthan Chandran, Ludo Van Den Bosch, Simon L Bullock, Philip Van Damme
A hexanucleotide repeat expansion in the C9orf72 gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). How this mutation leads to these neurodegenerative diseases remains unclear. Here, we show using patient stem cell-derived motor neurons that the repeat expansion impairs microtubule-based transport, a process critical for neuronal survival. Cargo transport defects are recapitulated by treating neurons from healthy individuals with proline-arginine and glycine-arginine dipeptide repeats (DPRs) produced from the repeat expansion...
April 2021: Science Advances
Norio Sugawara, Norio Yasui-Furukori, Kazutaka Shimoda
BACKGROUND: Depopulation accompanied by population aging is a major public health concern in Japan. Although adequate allocation of mental healthcare resources is needed, there have been few studies on the impact of population change on the supply-demand balance for mental illness in Japan. The aim of this study is to predict psychiatrists' distribution for patients with mental illness via a utilization-based approach. METHODS: We set patients with schizophrenia, mood disorders, vascular dementia or Alzheimer's disease as study subjects and conducted analyses for 2015, 2025, 2035, and 2045 across all prefectures...
April 9, 2021: Human Resources for Health
Gerhard Leinenga, Wee Kiat Koh, Jürgen Götz
BACKGROUND: Aducanumab is an anti-amyloid-β (Aβ) antibody that achieved reduced amyloid pathology in Alzheimer's disease (AD) trials; however, it is controversial whether it also improved cognition, which has been suggested would require a sufficiently high cumulative dose of the antibody in the brain. Therapeutic ultrasound, in contrast, has only begun to be investigated in human AD clinical trials. We have previously shown that scanning ultrasound in combination with intravenously injected microbubbles (SUS), which temporarily and safely opens the blood-brain barrier (BBB), removes amyloid and restores cognition in APP23 mice...
April 9, 2021: Alzheimer's Research & Therapy
Yvonne Feeney, Stephanie Daley, Breda Flaherty, Sube Banerjee
BACKGROUND: As the numbers of people with dementia worldwide rises, there is a need for improved knowledge and awareness about the condition across the healthcare workforce. There are concerns that traditional models of healthcare education, which focus on short-term episodes of care, limit student understanding of long-term conditions. We therefore designed and delivered the Time for Dementia programme at five Universities in the UK. Through longitudinal contact with families living with dementia, healthcare students gain increased understanding about the experiences of living with dementia...
April 9, 2021: BMC Medical Education
Chiaki Ura, Tsuyoshi Okamura, Sachiko Yamazaki, Masaya Shimmei, Keisuke Torishima, Akira Eboshida, Yu Kawamuro
BACKGROUND: Green care farms, which offer care for people with dementia in a farm setting, have been emerging in the Netherlands. The aim of this study was to 1) implement green care farms which use rice farming in Japan, 2) explore the positive experiences of rice farming care, and 3) compare the effect of rice farming care to that of usual care on well-being and cognitive ability. METHODS: We developed a new method of green care farm in Japan which uses rice farming, a farming that is practiced all over East Asia...
April 9, 2021: BMC Geriatrics
Halle Quang, Stephanie Wong, Masud Husain, Olivier Piguet, John R Hodges, Muireann Irish, Fiona Kumfor
Primary progressive aphasia (PPA) is characterised by predominant language and communication impairment. However, behavioural changes, such as apathy, are increasingly recognised. Apathy is defined as a reduction in motivation and goal-directed behaviour. Recent theoretical models have suggested that apathy can be delineated into multiple dimensions: executive apathy (i.e., deficits in maintaining goals and organisation), emotional apathy (i.e., emotional blunting and indifference) and initiation apathy (i...
March 16, 2021: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Maxime Taquet, John R Geddes, Masud Husain, Sierra Luciano, Paul J Harrison
BACKGROUND: Neurological and psychiatric sequelae of COVID-19 have been reported, but more data are needed to adequately assess the effects of COVID-19 on brain health. We aimed to provide robust estimates of incidence rates and relative risks of neurological and psychiatric diagnoses in patients in the 6 months following a COVID-19 diagnosis. METHODS: For this retrospective cohort study and time-to-event analysis, we used data obtained from the TriNetX electronic health records network (with over 81 million patients)...
April 1, 2021: Lancet Psychiatry
Ismael Luis Calandri, Lucia Crivelli, Florentina Morello Garcia, Ricardo Francisco Allegri
INTRODUCTION: Three Words-Three Shapes (3W3S) is a bedside test that assesses verbal and non-verbal memory and has proven useful in staging memory decline in amnestic disorders and primary progressive aphasia. Given its simple structure, the 3W3S can be easily adapted to other languages maintaining the original shapes and only modifying the words. We aim to validate a Spanish version of the 3W3S test and establish whether memory loss patterns present in amnesic disorders associated with Alzheimer's etiology and PPA were correctly characterized...
April 9, 2021: Applied Neuropsychology. Adult
Jinsei Jung, Seong Hoon Bae, Ji Hyuk Han, Sang Hyun Kwak, Gi Sung Nam, Phil Hyu Lee, Young Ho Sohn, Mijin Yun, Byung Seok Ye
BACKGROUND AND PURPOSE: The associations between hearing loss (HL) and the mechanisms underlying cognitive impairment (CI) remain unclear. We evaluated the effects of clinical factors, vascular magnetic resonance imaging (MRI) markers, and CI mechanisms on HL. METHODS: In total, 112 patients with CI (59% demented) and subjective HL prospectively underwent MRI, amyloid positron-emission tomography (PET), hearing evaluations, and neuropsychological tests including a language comprehension test...
April 2021: Journal of Clinical Neurology
Jae Won Jang, Jeong Hoon Park, Seongheon Kim, Seung Hwan Lee, Suk Hee Lee, Young Ju Kim
BACKGROUND AND PURPOSE: Dementia is rapidly becoming more common in the elderly population of South Korea, and there are regional difference in its demographics. This study investigated the trajectories in the prevalence and incidence of dementia based on the Seoul metropolitan area and other areas in South Korea using big data from the National Health Insurance Service (NHIS). METHODS: We examined a population-based elderly cohort obtained from the NHIS Senior Cohort (NHIS-SC) data set that comprises approximately half a million recipients of medical insurance in South Korea during 2003-2015...
April 2021: Journal of Clinical Neurology
Minkyeong Kim, Jong Hyeon Ahn, Jun Kyu Mun, Eun Hyeok Choi, Ji Sun Kim, Jinyoung Youn, Jin Whan Cho
BACKGROUND AND PURPOSE: Spinocerebellar ataxias (SCAs) are the most common form of hereditary ataxias. Extracerebellar signs have been well described and are helpful in differentiating the SCA subtypes. However, there are few reports on the early-stage extracerebellar signs in various SCA subtypes. This study explored the clinical and magnetic resonance imaging (MRI) characteristics of early-stage SCAs in the Korean population. METHODS: We retrospectively reviewed the medical records of genetically confirmed SCA patients with a disease duration of <5 years...
April 2021: Journal of Clinical Neurology
Casper T Briels, Cornelis J Stam, Philip Scheltens, Alida A Gouw
OBJECTIVE: To determine differences in clinical presentation and disease progression between patients with dementia due to AD with visually normal and abnormal EEG recordings. We hypothesized that patients with normal electroencephalographs (EEGs) are a representation of the heterogeneity of AD. We expected this group to have a phenotype with relatively predominant hippocampal atrophy, memory deficits, and a slower disease progression. METHODS: Patients were included based on diagnosis of dementia due to AD, positive amyloid and tau cerebrospinal fluid (CSF) biomarkers, and the availability of EEG recordings...
April 9, 2021: Annals of Clinical and Translational Neurology
Sergio Venturini, Daniele Orso, Francesco Cugini, Massimo Crapis, Sara Fossati, Astrid Callegari, Tommaso Pellis, Maurizio Tonizzo, Alessandro Grembiale, Alessia Rosso, Mario Tamburrini, Natascia D'Andrea, Luigi Vetrugno, Tiziana Bove
BACKGROUND: Early detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients who could develop a severe form of COVID-19 must be considered of great importance to carry out adequate care and optimise the use of limited resources. AIMS: To use several machine learning classification models to analyse a series of non-critically ill COVID-19 patients admitted to a general medicine ward to verify if any clinical variables recorded could predict the clinical outcome...
April 9, 2021: Internal Medicine Journal
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