Chelsea Liu, Yuan Ma, Albert Hofman, Reem Waziry, Silvia Koton, James R Pike, B Gwen Windham, Melinda C Power, A Richey Sharrett, Rebecca F Gottesman
INTRODUCTION: Lower education is associated with higher burden of vascular risk factors in mid-life and higher risk of dementia in late life. We aim to understand the causal mechanism through which vascular risk factors potentially mediate the relationship between education and dementia. METHODS: In a cohort of 13,368 Black and White older adults in the Atherosclerosis Risk in Communities Study, we assessed the relationship between education (grade school, high school without graduation, high school graduate or equivalent, college, graduate/professional school) and dementia among all participants and among those with incident stroke...
March 26, 2023: Annals of Neurology
Dehong Yu, Can Yang, Yi Liu, Tao Lu, Lizi Li, Gang Chen, Zerong Liu, Yanfang Li
Alzheimer's disease (AD) is the most common type of age-related dementia. Inhibition of butyrylcholinesterase (BChE) emerge as an effective therapeutic target for AD. A series of new substituted acetamide derivatives were designed, synthesized and evaluated for their ability to inhibit BChE. The bioassay results revealed that several compounds displayed attractive inhibition against BChE). Among them, compound 8c exhibited the highest BChE inhibition with IC50 values of 3.94 μM. Lineweaver Burk plot indicated that 8c acted as a mixed-type BChE inhibitor...
March 25, 2023: Scientific Reports
Peter Calvert, Dhiraj Gupta, Gregory Y H Lip
Atrial fibrillation has a recognised association with not only stroke, but also neurocognitive impairment and both vascular and Alzheimer's dementia. Effective management of atrial fibrillation can reduce the risk of such complications. In this narrative review article, we discuss the pathophysiological links between atrial fibrillation and dementia, as well as the benefits of adherence to the guideline-recommended 'ABC' Pathway.
March 25, 2023: European Heart Journal. Cardiovascular Pharmacotherapy
Wenqi Gan, Kevin J Manning, Ekaterina G Cleary, Richard H Fortinsky, Doug Brugge
BACKGROUND: Some studies suggest that ambient particulate air pollution is associated with cognitive decline. However, the findings are mixed, and there is no relevant research examining the influences of ultrafine particles (UFP), which may have more toxicity than larger particles. We therefore conducted this study to investigate whether residential UFP exposure is associated with cognitive decline using data from the Alzheimer's Disease Research Centers in the United States. METHODS: This is a longitudinal study of participants who were aged 65 years and older and had normal cognitive status at baseline...
March 23, 2023: Environmental Research
Javier de Miguel-Diez, Ana Lopez-de-Andres, Rodrigo Jimenez-Garcia, Valentin Hernández-Barrera, David Carabantes-Alarcon, Jose J Zamorano-Leon, Ricardo Omaña-Palanco, Francisco Javier González-Barcala, Natividad Cuadrado-Corrales
AIMS: To assess changes in prevalence and the effects on hospital outcomes of dementia among patients hospitalized with an acute exacerbation of chronic obstructive pulmonary disease (AE-COPD); and to evaluate sex-differences, as well as the impact of COVID-19 pandemic in this relationship. METHODS: We used a nationwide discharge database to select patients admitted with AE-COPD in Spain from 2011 to 2020. We identified those with any type of dementia, vascular dementia (VaD) or Alzheimer's disease (AD)...
March 23, 2023: Respiratory Medicine
Michael W Weiner, Anna Aaronson, Joseph Eichenbaum, Winnie Kwang, Miriam T Ashford, Shilpa Gummadi, Jessica Santhakumar, Monica R Camacho, Derek Flenniken, Juliet Fockler, Diana Truran-Sacrey, Aaron Ulbricht, R Scott Mackin, Rachel L Nosheny
INTRODUCTION: Remote, internet-based methods for recruitment, screening, and longitudinally assessing older adults have the potential to facilitate Alzheimer's disease (AD) clinical trials and observational studies. METHODS: The Brain Health Registry (BHR) is an online registry that includes longitudinal assessments including self- and study partner-report questionnaires and neuropsychological tests. New initiatives aim to increase inclusion and engagement of commonly under-included communities using digital, community-engaged research strategies...
March 25, 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
C M C O'Connor, R G Poulos, C Preti, M Heldon, L Barclay, E Beattie, C J Poulos
ISSUE ADDRESSED: Arts on Prescription at Home ([email protected]) involves a professional artist visiting a person with dementia and their informal carer(s) in their own home to engage them in participatory art making. While there is evidence for the use of these programs, more work is needed to facilitate effective implementation. This study explored contextual barriers and enablers to implementation of [email protected] within a real-world community aged care service. METHODS: Two remote focus groups were conducted at a community aged care provider in Sydney, Australia...
March 25, 2023: Health Promotion Journal of Australia
Shreyasee Das, Julie Goossens, Dirk Jacobs, Nele Dewit, Yolande A L Pijnenburg, Sjors G J G In 't Veld, Charlotte E Teunissen, Eugeen Vanmechelen
BACKGROUND: Loss of synaptic functionality has been recently identified as an early-stage indicator of neurological diseases. Consequently, monitoring changes in synaptic protein levels may be relevant for observing disease evolution or treatment responses in patients. Here, we have studied the relationship between fluid biomarkers of neurodegeneration and synaptic dysfunction in patients with Alzheimer's disease (AD), frontotemporal dementia (FTD), and subjective cognitive decline (SCD)...
March 24, 2023: Alzheimer's Research & Therapy
Frank C T van der Heide, Simone J P M Eussen, Alfons J H M Houben, Ronald M A Henry, Abraham A Kroon, Carla J H van der Kallen, Pieter C Dagnelie, Martien C J M van Dongen, Tos T J M Berendschot, Jan S A G Schouten, Carroll A B Webers, Marleen M J van Greevenbroek, Anke Wesselius, Casper G Schalkwijk, Annemarie Koster, Jacobus F A Jansen, Walter H Backes, Joline W J Beulens, Coen D A Stehouwer
BACKGROUND: Microvascular dysfunction (MVD) is an important contributor to major clinical disease such as stroke, dementia, depression, retinopathy, and chronic kidney disease. Alcohol consumption may be a determinant of MVD. OBJECTIVE: Main objectives were (1) to study whether alcohol consumption was associated with MVD as assessed in the brain, retina, skin, kidney and in the blood; and (2) to investigate whether associations differed by history of cardiovascular disease or sex...
March 24, 2023: Cardiovascular Diabetology
Noreen Orr, Rebecca Abbott, Alison Bethel, Sarah Paviour, Rebecca Whear, Ruth Garside, Joanna Thompson Coon
BACKGROUND: There is some evidence to suggest that animal-assisted interventions can have beneficial impact for residents in long-term care, but the focus of the evidence has largely been on behavioural and psychosocial measured outcomes. Animals, either as companion animals or in the form of pet/animal-assisted therapy, may provide benefits in the form of social contact, as well as opportunities for sensory experiences and meaningful engagement not picked up by outcome tools. This review aimed to create a state-of-knowledge synthesis, bringing together qualitative and quantitative findings, on the impact of animal-human interaction on care home residents and care home staff...
March 25, 2023: BMC Geriatrics
Chloe A Stewart, Derek G V Mitchell, Penny A MacDonald, Stephen H Pasternak, Paul F Tremblay, Elizabeth Finger
Guilt is a negative emotion, elicited by realizing one has caused actual or perceived harm to another person. Anecdotally, guilt often is described as a visceral and physical experience. However, while the way that the body responds to and contributes to emotions is well known in basic emotions, little is known about the characteristics of guilt as generated by the autonomic nervous system. This study investigated the physiologic signature associated with guilt in adults with no history of psychological or autonomic disorder...
March 25, 2023: Cognitive, Affective & Behavioral Neuroscience
Shih-Kuang Chiang, Jia-Rong Jhong, Chia-Yu Wang
PURPOSE: This study investigates whether using group Cognitive Stimulation Therapy (CST) effectively improves functioning among middle-aged and elderly patients with chronic schizophrenia and a below-normal cognitive range. METHODS: The study included an experimental group (N Z 24), which was divided into two sub-groups to receive group CST, and a control group (N Z 24), who received treatment as usual (TAU). We assessed cognitive functions using the Mini-Mental Status Examination (MMSE)...
March 22, 2023: Journal of the Formosan Medical Association
Huiying Wang, Shubing Cai, Thomas Caprio, Joseph Goulet, Orna Intrator
OBJECTIVE: Proper initiation and reduction of opioids is important in providing effective and safe pain relief to Veterans with dementia, including in Community Living Centers (CLCs). We examined the trends in aggregated monthly risk-adjusted opioid administration days and dosage over 3 opioid safety regulatory periods: pre-Opioid Safety Initiative period (October 1, 2012-June 30, 2013; period 1), pre-CDC Clinical Practice Guideline period (January 1, 2014-November 30, 2015, period 2) and post-Veterans Affairs Clinical Practice Guideline period (March 1, 2017-September 30, 2018; period 3)...
March 21, 2023: Journal of the American Medical Directors Association
Diana Piol, Tessa Robberechts, Sandrine Da Cruz
Key early features of amyotrophic lateral sclerosis (ALS) are denervation of neuromuscular junctions and axonal degeneration. Motor neuron homeostasis relies on local translation through controlled regulation of axonal mRNA localization, transport, and stability. Yet the composition of the local transcriptome, translatome (mRNAs locally translated), and proteome during health and disease remains largely unexplored. This review covers recent discoveries on axonal translation as a critical mechanism for neuronal maintenance/survival...
March 23, 2023: Neuron
Micaela Nievas, Leonardo Romorini, Luciana Isaja, Giulia S Clas, Soledad Rodríguez-Varela, Sofía Mucci, Tatiana Itzcovich, Bruno de Ambrosi, María E Scassa, Gustavo E Sevlever, Ezequiel I Surace, Mariela C Marazita
Human induced pluripotent stem cell (hiPSC) line INEUi001-A was reprogrammed from peripheral blood mononuclear cells (PBMC) using the lentiviral-hSTEMCCA-loxP vector. PBMCs were obtained from a 75- year-old female ALS/FTD disease patient carrying a heterozygous deletion within the C9ORF72 hexanucleotide repeat region resulting in a GGGGCCG sequence (∼1.16 repeats). C9ORF72 genotype was maintained and stemness and pluripotency confirmed in INEUi001-A hiPSC line.
March 21, 2023: Stem Cell Research
Takehiko Yamanashi, Eleanor J Sullivan, Katie R Comp, Yoshitaka Nishizawa, Cade C Akers, Gloria Chang, Manisha Modukuri, Tammy Tran, Zoe-Ella E M Anderson, Pedro S Marra, Kaitlyn J Crutchley, Nadia E Wahba, Masaaki Iwata, Matthew D Karam, Nicolas O Noiseux, Hyunkeun R Cho, Gen Shinozaki
OBJECTIVE: To investigate the relationship between history of anti-inflammatory medication use and delirium risk, as well as long-term mortality. METHODS: In this retrospective cohort study, subjects recruited between January 2016 and March 2020 were analyzed. Information about anti-inflammatory medication use history including aspirin, NSAIDs, glucosamine, and other anti-inflammatory drugs, was collected. Logistic regression analysis investigated the relationship between anti-inflammatory medications and delirium...
March 12, 2023: Journal of Psychosomatic Research
Timothy Mwanje Kintu, Vanessa Katengeke, Ronald Kamoga, Tricia Nguyen, Josephine Nambi Najjuma, David Kitya, Edith K Wakida, Celestino Obua, Godfrey Zari Rukundo
BACKGROUND: As the burden of dementia continues to rise in sub-Saharan Africa, it is crucial to develop an evidence base for potentially modifiable risk factors such as Traumatic Brain Injury (TBI). Cognitive impairment may result from TBI and since it is an established prodromal form of dementia, we investigated the burden of cognitive impairment and associated factors in persons with a history of TBI in southwestern Uganda. METHODS: This was a community-based quantitative study with a cross-sectional design among 189 persons with a history of TBI in southwestern Uganda...
2023: PLOS Glob Public Health
Eirini Mamalaki, Sokratis Charisis, Niki Mourtzi, Alexandros Hatzimanolis, Eva Ntanasi, Mary H Kosmidis, Vasilios C Constantinides, Georgios Pantes, Dimitra Kolovou, Efthimios Dardiotis, Georgios Hadjigeorgiou, Paraskevi Sakka, Yian Gu, Mary Yannakoulia, Nikolaos Scarmeas
Obejctives: The aim of the current study was to investigate whether genetic risk factors may moderate the association between adherence to the Mediterranean diet and AD incidence. Mehtods: The sample was drawn from the HELIAD study, a longitudinal study with a follow-up interval of 3 years. In total 537 older adults without dementia or AD at baseline were included. Adherence to the Mediterranean diet was assessed at baseline and AD diagnosis was determined at both visits. A Polygenic Index for late onset AD (PGI-AD) was constructed...
March 24, 2023: Nutritional Neuroscience
Oladayo Bifarin, Zalihe Kamil-Thomas
No abstract text is available yet for this article.
March 24, 2023: International Psychogeriatrics
Charles B A Musselwhite
No abstract text is available yet for this article.
March 24, 2023: International Psychogeriatrics
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