Solaphat Hemrungrojn, Sookjaroen Tangwongchai, Thammanard Charoenboon, Muthita Panasawat, Thitiporn Supasitthumrong, Pisit Chaipresertsud, Pacharaporn Maleevach, Yuttachai Likitjaroen, Kammant Phanthumchinda, Michael Maes
BACKGROUND: The Montreal Cognitive Assessment (MoCA) is an effective and applicable screening instrument to confirm the diagnosis of amnestic mild cognitive impairment (aMCI) from patients with Alzheimer's disease (AD) and healthy controls (HCs). OBJECTIVES: This study aimed to determine the reliability and validity of the following: (a) Thai translation of the MoCA (MoCA-Thai) and (b) delineate the key features of aMCI based on the MoCA subdomains. METHODS: This study included 60 HCs, 61 aMCI patients, and 60 AD patients...
July 29, 2021: Dementia and Geriatric Cognitive Disorders
Vanteemar S Sreeraj, Joan C Puzhakkal, Bharath Holla, Ravi Kumar Nadella, Sweta Sheth, Srinivas Balachander, Dhruva Ithal, Furkhan Ali, Biju Viswanath, Kesavan Muralidharan, Ganesan Venkatasubramanian, John P John, Vivek Benegal, Pratima Murthy, Mathew Varghese, Yc Janardhan Reddy, Sanjeev Jain
BACKGROUND: Minor physical anomalies (MPA) are markers of impaired neurodevelopment during the prenatal stage. Assessing MPA across psychiatric disorders may help understand their shared nature. In addition, MPA in family members would indicate a shared liability and endophenotype potential. We examined familial aggregation of MPA and their role as transdiagnostic and disorder-specific markers of 5 major psychiatric/neuropsychiatric conditions (schizophrenia, bipolar disorder, substance dependence, obsessive-compulsive disorder, and Alzheimer's dementia)...
July 20, 2021: Journal of Psychiatric Research
Doortje W Dekens, Ulrich L M Eisel, Leonie Gouweleeuw, Regien G Schoemaker, Peter P De Deyn, Petrus J W Naudé
Chronic (neuro)inflammation plays an important role in many age-related central nervous system (CNS) diseases, including Alzheimer's disease, Parkinson's disease and vascular dementia. Inflammation also characterizes many conditions that form a risk factor for these CNS disorders, such as physical inactivity, obesity and cardiovascular disease. Lipocalin 2 (Lcn2) is an inflammatory protein shown to be involved in different age-related CNS diseases, as well as risk factor conditions thereof. Lcn2 expression is increased in the periphery and the brain in different age-related CNS diseases and also their risk factor conditions...
July 26, 2021: Ageing Research Reviews
Filipe Maximiano Sousa, Maroussia Roelens, Brian Fricker, Amaury Thiabaud, Anne Iten, Alexia Cusini, Domenica Flury, Michael Buettcher, Franziska Zukol, Carlo Balmelli, Petra Zimmermann, Nicolas Troillet, Danielle Vuichard-Gysin, Peter W Schreiber, Sara Bernhard-Stirnemann, Sarah Tschudin-Sutter, Yvonne Nussbaumer-Ochsner, Rami Sommerstein, Roman Gaudenz, Jonas Marschall, Laurence Senn, Céline Gardiol, Olivia Keiser, Gertraud Schüpbach, Monica Wymann, Beatriz Vidondo, Ch-Sur Study Group
BACKGROUND: As clinical signs of COVID-19 differ widely among individuals, from mild to severe, the definition of risk groups has important consequences for recommendations to the public, control measures and patient management, and needs to be reviewed regularly. AIM: The aim of this study was to explore risk factors for in-hospital mortality and intensive care unit (ICU) admission for hospitalised COVID-19 patients during the first epidemic wave in Switzerland, as an example of a country that coped well during the first wave of the pandemic...
July 19, 2021: Swiss Medical Weekly
Nathan A Lewis, Jamie E Knight
BACKGROUND: systemic inflammation appears to play an important role in the pathogenesis and expression of Alzheimer's disease and other dementias. Previous research has found that elevated levels of serum C-reactive protein (CRP) is associated with poorer cognitive functioning and increased risk for dementia. However, most studies are limited by single CRP measurements, which fail to capture long-term inflammatory exposures or dynamic changes in inflammation and cognition which may occur across repeated measurements...
July 29, 2021: Age and Ageing
Dimitrios Sagris, Gregory Y H Lip
No abstract text is available yet for this article.
July 29, 2021: Age and Ageing
Melissa Co, Elyse Couch, Qian Gao, Andrea Martinez, Jayati Das-Munshi, Matthew Prina
OBJECTIVES: Although there are disparities in both risk of developing dementia and accessibility of dementia services for certain minority ethnic groups in the United States and United Kingdom, disparities in survival after a dementia diagnosis are less well-studied. Our objective was to systematically review the literature to investigate racial/ethnic differences in survival and mortality in dementia. METHODS: We searched Embase, Ovid MEDLINE, Global Health and PsycINFO from inception to November 2018 for studies comparing survival or mortality over time in at least two race/ethnicity groups...
June 18, 2021: International Journal of Geriatric Psychiatry
Sohita Dhillon
Aducanumab (aducanumab-avwa; Aduhelm™) is a human, immunoglobulin gamma 1 (IgG1) monoclonal antibody directed against aggregated soluble and insoluble forms of amyloid β. It has been co-developed by Biogen and Eisai under license from Neurimmune for the treatment of Alzheimer's disease. In June 2021, aducanumab received its first approval in the USA for the treatment of Alzheimer's disease. According to the US FDA prescribing information, treatment should be initiated in patients with mild cognitive impairment or mild dementia stage of disease, the population in which treatment was initiated in clinical trials...
July 29, 2021: Drugs
Megumi Inoue, Mai Hasegawa, Catherine J Tompkins, Catherine M Donnelly
The older foreign-born population is predicted to increase in the United States. As a whole, this population in the long-term care setting is more likely to face greater challenges associated with loneliness and social isolation due to their smaller social networks, language and cultural differences. The benefits of person-centered care have been widely recognized and may be a potential remedy for such challenges felt by older immigrants. Using a qualitative case study approach, this study explored the staff perceptions of a culturally responsive companion program provided to an older Japanese woman with advanced dementia in the long-term care setting to understand the potential benefits of such a program...
July 29, 2021: Journal of Cross-cultural Gerontology
Julong Sun, Shiqing Zhou, Da Sheng, Nan Li, Jue Wang, Changbo Jiang
As a new cyanobacterial neurotoxin generated by cyanobacteria, BMAA was closely related to amyotrophic lateral sclerosis-parkinsonism dementia complex (ALS/PDC). In this study, the degradation of BMAA by UV/chlorine process was investigated under the impacts of chlorine dosage, NOM dosage, pH and alkalinity. Results showed that only 10% of BMAA was removed by UV irradiation and 46.8% by chlorination in 5 min, however, 98.6% of BMAA was removed by UV/chlorine process in 5 min. The reaction rates were increased under alkaline conditions, but all achieved complete degradation in 5 min...
July 3, 2021: Chemosphere
Yuhan Ma, Jing Wang, Dihui Xu, Yabing Chen, Xiaodong Han
It has been reported that microcystin-leucine-arginine (MC-LR) can enter into the brain and demonstrate neurotoxicity resulting in learning and memory deficits. While, there is still a lack of clear understanding of the related molecular mechanisms. In this study, we observed β-amyloid (Aβ) accumulation and tau hyperphosphorylation (p-tau) at sites of Ser396 and Thr205 in mouse hippocampus and cortex, Alzheimer's disease (AD) like changes, after chronic exposure to MC-LR at different concentrations (1, 7...
June 29, 2021: Science of the Total Environment
Khalil Mallah, Kazem Zibara, Coline Kerbaj, Ali Eid, Nour Khoshman, Zahraa Ousseily, Abir Kobeissy, Tristan Cardon, Dasa Cizkova, Firas Kobeissy, Isabelle Fournier, Michel Salzet
Traumatic brain injury (TBI) represents one of the major public health concerns worldwide due to the increase in TBI incidence as a result of injuries from daily life accidents such as sports and motor vehicle transportation as well as military-related practices. This type of central nervous system trauma is known to predispose patients to several neurological disorders such as Parkinson's disease, Alzheimer's disease, chronic trauamatic encephalopathy, and age-related Dementia. Recently, several proteomic and lipidomic platforms have been applied on different TBI studies to investigate TBI-related mechanisms that have broadened our understanding of its distinct neuropathological complications...
July 29, 2021: Mass Spectrometry Reviews
Niklas Frahm, Michael Hecker, Uwe Zettl
Polypharmacy is an important aspect of medication management and particularly affects elderly and chronically ill people. Patients with dementia, Parkinson's disease (PD) or multiple sclerosis (MS) are at high risk for multimedication due to their complex symptomatology. Our aim was to provide an overview of different definitions of polypharmacy and to present the current state of research on polypharmacy in patients with dementia, PD or MS. The most common definition of polypharmacy in the literature is the concomitant use of ≥5 medications (quantitative definition approach)...
July 27, 2021: Current Pharmaceutical Design
J E Blümel, E Arteaga, M S Vallejo, E Ojeda, P Meza, M Martino, D Rodríguez-Vidal, M Ñañez, K Tserotas, J Rojas, M A Rodrígues, M T Espinoza, C Salinas, J Párraga-Párraga, P Chedraui
BACKGROUND: Dementia is a major public health problem. Estrogen is a regulator of the central nervous system and its deficit could be involved in cognitive decline in older women. OBJECTIVE: This study aimed to evaluate the association of bilateral oophorectomy, menopause hormone therapy (MHT) and other factors on mild cognitive impairment (MCI). METHOD: The case-control study included 941 otherwise healthy postmenopausal women aged 60 years and over from six Latin American countries...
July 29, 2021: Climacteric: the Journal of the International Menopause Society
Ben Kamsvaag, Sverre Bergh, Jūratė Šaltytė Benth, Geir Selbaek, Kjerstin Tevik, Anne-Sofie Helvik
OBJECTIVES: To explore alcohol consumption among older Norwegian adults with symptoms of cognitive decline, assess the agreement between the reports of older adults and their next of kin regarding a person's alcohol consumption, and explore clinical and sociodemographic variables associated with agreement. METHOD: Alcohol consumption was measured among 3608 older adults consulting specialist health care for symptoms of cognitive decline. Agreement between the participant and their next of kin regarding the participant's alcohol consumption was assessed with a weighted kappa (κ)...
July 29, 2021: Aging & Mental Health
Pil Hyung Lee, Sojeong Park, Hyewon Nam, Do-Yoon Kang, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Seong-Wook Park, Cheol Whan Lee
Background Limited data are available on intracranial hemorrhage (ICH) in patients undergoing antithrombotic therapy after percutaneous coronary intervention (PCI). Methods and Results Using the Korean National Health Insurance Service database, we identified 219 274 patients without prior ICH and who underwent a first PCI procedure between 2007 and 2016 and analyzed nontraumatic ICH and all-cause mortality. ICH after PCI occurred in 4171 patients during a median follow-up of 5.6 years (overall incidence rate: 3...
July 29, 2021: Journal of the American Heart Association
Nelsan Pourhadi, Lina S Mørch, Ellen A Holm, Christian T Torp-Pedersen, Amani Meaidi
INTRODUCTION: Use of systemic hormone therapy has been positively associated with development of dementia. Little is known about the dose-dependent effect of vaginal estradiol on dementia risk. METHODS: We assessed associations between cumulative dose of vaginal estradiol tablets and dementia in a case-control study nested in a nationwide Danish cohort of women aged 50 to 60 years at study initiation, who did not use systemic hormone therapy. Each case was age-matched to 10 female controls...
July 28, 2021: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
Antoine Garnier-Crussard, Salma Bougacha, Miranka Wirth, Sophie Dautricourt, Siya Sherif, Brigitte Landeau, Julie Gonneaud, Robin De Flores, Vincent de la Sayette, Denis Vivien, Pierre Krolak-Salmon, Gaël Chételat
INTRODUCTION: White matter hyperintensities (WMH) are often described in Alzheimer's disease (AD), but their topography and specific relationships with cognition remain unclear. METHODS: Regional WMH were estimated in 54 cognitively impaired amyloid beta-positive AD (Aβpos-AD), compared to 40 cognitively unimpaired amyloid beta-negative older controls (Aβneg-controls) matched for vascular risk factors. The cross-sectional association between regional WMH volume and cognition was assessed within each group, controlling for cerebral amyloid burden, global cortical atrophy, and hippocampal atrophy...
July 28, 2021: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
Yu Sun, Masao Iwagami, Taeko Watanabe, Nobuo Sakata, Takehiro Sugiyama, Atsushi Miyawaki, Nanako Tamiya
AIM: Family caregivers can experience psychological distress, resulting in physical and mental health problems, and discontinuation of caregiving. This study's objective was to examine factors associated with caregiver psychological distress. METHODS: We analyzed data from the Comprehensive Survey of Living Conditions in 2007, 2010, 2013 and 2016, which included 12 504 pairs of caregivers and care recipients sharing a household in Japan. Kessler's Psychological Distress Scale (K6) was used to measure caregiver psychological distress...
July 28, 2021: Geriatrics & Gerontology International
Xueling Suo, Du Lei, Nannan Li, Junying Li, Jiaxin Peng, Wenbin Li, Jing Yang, Kun Qin, Graham J Kemp, Rong Peng, Qiyong Gong
Patients with Parkinson's disease with mild cognitive impairment (PD-M) progress to dementia more frequently than those with normal cognition (PD-N), but the underlying neurobiology remains unclear. This study aimed to define the specific morphological brain network alterations in PD-M, and explore their potential diagnostic value. Twenty-four PD-M patients, 17 PD-N patients, and 29 healthy controls (HC) underwent a structural MRI scan. Similarity between interregional gray matter volume distributions was used to construct individual morphological brain networks...
July 28, 2021: Human Brain Mapping
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