Trine Holt Clemmensen, Henrik Hein Lauridsen, Karen Andersen-Ranberg, Hanne Kaae Kristensen
BACKGROUND: Informal carers of people with dementia report having unmet needs for support and few supportive interventions have been shown to be effective. There is a need to develop needs assessment instruments and supportive interventions with a holistic and person-centred approach to meet the various and complex needs of carers. The aim of this study was to provide an overview of carers' support needs when caring for people with dementia with the objectives to map and synthesise knowledge on key concepts of carers' support needs...
August 11, 2020: Scandinavian Journal of Caring Sciences
Kristina M Kokorelias, Lily Nguyen, Genalyn Elane, Marina Bastawrous Wasilewski, Nira Rittenberg, Jill I Cameron
BACKGROUND: Siblings often share in the care of parents with dementia, but little is known about how care is shared. Research suggests that in comparison with their brothers, sisters provide the majority of care to a parent with dementia and this can contribute to the sisters experiencing poorer health outcomes. There is limited knowledge about how to guide siblings who share in the care of a parent with dementia. AIM: Our qualitative descriptive study sought to explore the experiences of adult daughters sharing care responsibilities with their siblings...
August 11, 2020: Scandinavian Journal of Caring Sciences
Inkyoung Cho, SangYun Kim, Jeong Gue Choi, Joon-Ho Shin
INTRODUCTION: Subjective memory complaints (SMCs) among stroke patients are common. To date, reports on SMCs using the Subjective Memory Complaint Questionnaire (SMCQ) are limited. We provided descriptive information on SMCs using the SMCQ alongside objective neuropsychological function assessment in stroke patients and established the sensitivity of SMCQ for post-stroke dementia. METHODS: In total, 419 consecutive stroke patients who were admitted to a stroke unit for younger populations (age <65 years) at a rehabilitation hospital from June 1, 2014, to January 1, 2020, were reviewed...
August 11, 2020: Dementia and Geriatric Cognitive Disorders
Silvia Mejia-Arango, Rene Nevarez, Alejandra Michaels-Obregon, Belem Trejo-Valdivia, Laura Rosario Mendoza-Alvarado, Ana Luisa Sosa-Ortiz, Adrian Martinez-Ruiz, Rebeca Wong
OBJECTIVE: Describe the protocol sample and instruments of the Cognitive Aging Ancillary Study in Mexico (Mex-Cog). The study performs an in-depth cognitive assessment in a subsample of older adults of the ongoing Mexican Health and Aging Study (MHAS). The Mex-Cog is part of the Harmonized Cognitive Assessment Protocol (HCAP) design to facilitate cross-national comparisons of the prevalence and trends of dementia in aging populations around the world, funded by the National Institute on Aging (NIA)...
July 27, 2020: Archives of Gerontology and Geriatrics
Sara Ojaghi, Soheila Mohammadi, Mojtaba Amani, Sirous Ghobadi, Nooshin Bijari, Sajjad Esmaeili, Reza Khodarahmi
Today, Alzheimer's disease (AD) as the most prevalent type of dementia turns into one of the most severe health problems. Neurofibrillary tangle (NFT), mostly comprised of fibrils formed by Tau, is a hallmark of a class of neurodegenerative diseases. Tau protein promotes assembly and makes stable microtubules that play a role in the appropriate function of neurons. Polyanionic cofactors such as heparin, and azo dyes, can induce aggregation of tau protein in vitro. Sunset Yellow is a food colorant used widely in food industries...
July 22, 2020: Bioorganic Chemistry
Joanne Jiang, Katherine Young, Christian J Pike
Alzheimer's disease is characterized by sex differences that may involve sex hormone exposure during development. Finger length ratios, an indirect measure of prenatal androgen exposure, were found to significantly differ in women with and without dementia. This finding links a relatively feminine in utero development with vulnerability to dementia in women.
August 6, 2020: Early Human Development
Marc Schatz, Sharnikha Saravanan, Nathan D d'Adesky, Helen Bramlett, Miguel A Perez-Pinzon, Ami P Raval
Menopause, an inevitable event in a woman's life, significantly increases risk of bone resorption and diseases such as Alzheimer's, vascular dementia, cardiac arrest, and stroke. The sole role of bones, as traditionally regarded, is to provide structural support for skeletal muscles and allow for ambulation, however this concept is becoming quickly outdated. New literature has emerged that suggests the bone cell-derived hormone osteocalcin (OCN) plays a pivotal role in cognition. OCN levels are correlated with bone mass density and bone turnover, and thus are strongly influenced by the changes associated with menopause...
August 8, 2020: Frontiers in Neuroendocrinology
Giulia Torromino, Adriana Maggi, Elvira De Leonibus
Women are more prone than men to develop age-related dementia, such as Alzheimer' disease (AD). This has been linked to the marked decrease in circulating estrogens during menopause. This review proposes to change this perspective and consider women's vulnerability to developing AD as a consequence of sex differences in the neurobiology of memory, focusing on the hippocampus. The hippocampus of cognitively impaired subjects tends to shrink with age; however, in many cases, this can be prevented by exercise or cognitive training, suggesting that if you do not use the hippocampus you lose it...
August 8, 2020: Progress in Neurobiology
Alfonso Diaz, Guadalupe Muñoz-Arenas, Karen Caporal-Hernandez, Rubén Vázquez-Roque, Gustavo Lopez-Lopez, Anna Kozina, Blanca Espinosa, Gonzalo Flores, Samuel Treviño, Jorge Guevara
Metabolic syndrome (MS) results from excessive consumption of high-calorie foods and sedentary lifestyles. Clinically, insulin resistance, abdominal obesity, hyperglycemia, dyslipidemia, and hypertension are observed. MS has been considered a risk factor in the development of dementia. In the brain, a metabolically impaired environment generates oxidative stress and excessive production of pro-inflammatory cytokines that deteriorate the morphology and neuronal function in the hippocampus, leading to cognitive impairment...
August 11, 2020: Synapse
Annette Keuning-Plantinga, Petrie F Roodbol, Wim P Krijnen, Evelyn J Finnema
AIMS AND OBJECTIVES: Overall, this study aimed to describe nursing care for patients with dementia in acute hospitals, with the objectives of describing the provided nursing care (1), nurses' attitudes and perceptions in caring for patients with dementia (2) and exploring how nurses deal with challenging behaviour (3). Additionally, we determined background variables associated with caring for people with dementia. BACKGROUND: Due to comorbidities, people with dementia are frequently admitted to acute care hospitals...
August 11, 2020: Journal of Clinical Nursing
Adrian De la Rosa, Gloria Olaso-Gonzalez, Coralie Arc-Chagnaud, Fernando Millan, Andrea Salvador-Pascual, Consolacion García-Lucerga, Cristina Blasco-Lafarga, Esther Garcia-Dominguez, Aitor Carretero, Angela G Correas, Jose Viña, Mari Carmen Gomez-Cabrera
Dementia is one of the greatest global challenges for health and social care in the 21st century. Alzheimer's disease (AD), the most common type of dementia, is by no means an inevitable consequence of growing old. Several lifestyle factors may increase, or reduce, an individual's risk of developing AD. Much has been written over the ages about the benefits of exercise and physical activity. Among the risk factors associated with AD is a low level of physical activity. The relationship between physical and mental health was established several years ago...
February 4, 2020: Journal of Sport and Health Science
Kirsten Thorsen, Marcia C N Dourado, Aud Johannessen
PURPOSE: To examine how people (<65 years) with young-onset dementia (YOD) express awareness of dementia and how they seem to handle awareness as a strategy to preserve quality of life over time. METHOD: A longitudinal qualitative study with individuals with YOD was performed with interviews every 6 months over 5 years for a maximum of 10 interviews. The interviews were analysed by modified grounded theory adapted to narrative inquiry. RESULTS: Awareness is a complex, multidimensional concept...
December 2020: International Journal of Qualitative Studies on Health and Well-being
Anthony Rinaldi, Jada J Stewart-Willis, David Scarisbrick, Zoe Proctor-Weber
In the context of diminishing reimbursement and patient access demands, researchers continually refine performance validity measures (PVMs) to maximize efficiency while maintaining confidence in obtained data. This is particularly true for high PVM failure populations (e.g., mTBI patients). The TOMMe10 (number of errors on first 10 TOMM items) is one method this study utilized for classifying PVM performance as pass/fail (fail defined as failure on 2 of 6 PVM scores, pass defined as 0/1 failures). The present study hypothesized that the TOMMe10 would have equitable sensitivity/specificity for identifying non-credible cognitive performance among veterans with mTBI compared to previous research findings and commonly used performance validity measures (e...
August 11, 2020: Applied Neuropsychology. Adult
Emerson M Wickwire, Sophia L Jobe, Sairam Parthasarathy, Jacob Collen, Vincent F Capaldi, Abree Johnson, Aparna Vadlamani, John M Levri, Steven M Scharf, Jennifer S Albrecht
STUDY OBJECTIVES: To characterize older adult Medicare beneficiaries seen by board-certified sleep medicine providers (BCSMPs) and identify predictors of being seen by a BCSMP. METHODS: Our data source was a random 5% sample of Medicare administrative claims data (2006-2013). BCSMPs were identified using a cross-matching procedure based on national provider identifiers (NPIs) available within the Medicare database and assigned based on the first sleep disorder diagnosis received...
August 11, 2020: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
Nicholas C Cullen, Henrik Zetterberg, Philip S Insel, Bob Olsson, Ulf Andreasson, Kaj Blennow, Oskar Hansson, Niklas Mattsson-Carlgren
OBJECTIVE: To investigate the statistical power of plasma, imaging, and cognition biomarkers as Alzheimer's disease (AD) clinical trial outcome measures. METHODS: Plasma neurofilament light, structural magnetic resonance imaging, and cognition were measured longitudinally in the Alzheimer's Disease Neuroimaging Initiative (ADNI) in control (amyloid PET or CSF Aβ42 negative [Aβ-] with Clinical Dementia Rating scale [CDR] = 0; n = 330), preclinical AD (Aβ + with CDR = 0; n = 218) and mild AD (Aβ + with CDR = 0...
August 11, 2020: Annals of Clinical and Translational Neurology
Ning Sun, Rangcheng Jia, Chunyan Guo, Tongda Sun, Xiaoxin Dong, Long Li
AIM: Long-term care needs are important for older adults with dementia in the West, but they have not received enough attention from China. This study evaluated the psychometric properties of a long-term care needs instrument for older Chinese adults with dementia. METHODS: A total of 1,212 older adults with dementia were recruited from five Chinese cities to complete a 30-item long-term care needs questionnaire. The reliability and validity of the questionnaire was evaluated using multiple assessments, including a content validity assessment, Cronbach's alpha, an item-to-total correlation test, and exploratory factor analysis...
August 11, 2020: Japan Journal of Nursing Science: JJNS
Gonzalo Flores, Gabriel D Flores-Gómez, Alfonso Díaz, Julio C Penagos-Corso, Tommaso Iannitti, Julio C Morales-Medina
Aging is a complex process that can lead to neurodegeneration and, consequently, several pathologies, including dementia. Physiological aging leads to changes in several body organs, including those of the central nervous system (CNS). Morphological changes in the CNS and particularly the brain result in motor and cognitive deficits affecting learning and memory and the circadian cycle. Characterizing neural modifications is critical to designing new therapies to target aging and associated pathologies. In this review, we compared aging to the changes occurring within the brain and particularly the limbic system...
August 11, 2020: Synapse
Guilherme Lopes Dornelles, Juliana Sorraila de Oliveira, Erin John Rieger de Almeida, Camila Benaduce Emanuelli Mello, Bernardo Rodrigues E Rodrigues, Cássia Bagolin da Silva, Letícia Dos Santos Petry, Micheli Mainardi Pillat, Taís Vidal Palma, Cinthia Melazzo de Andrade
Neuroinflammation is a predisposing factor for the development of cognitive impairment and dementia. Among the new molecules that are currently being studied, ellagic acid (EA) has stood out for its neuroprotective properties. The present study investigated the effects of ellagic acid in the object recognition test, oxidative stress, cholinergic neurotransmission, glial cell expression, and phosphorylated Tau protein expression. For this, 32 male Wistar rats received an intraperitoneal (IP) application of lipopolysaccharides (LPS) at a dose of 250 µg/kg or 0...
August 10, 2020: Neurochemical Research
Michael L Alosco, Jonathan D Cherry, Bertrand Russell Huber, Yorghos Tripodis, Zachary Baucom, Neil W Kowall, Nicole Saltiel, Lee E Goldstein, Douglas I Katz, Brigid Dwyer, Daniel H Daneshvar, Joseph N Palmisano, Brett Martin, Robert C Cantu, Robert A Stern, Victor E Alvarez, Jesse Mez, Thor D Stein, Ann C McKee
Chronic traumatic encephalopathy (CTE) is a tauopathy associated with repetitive head impacts (RHI) that has been neuropathologically diagnosed in American football players and other contact sport athletes. In 2013, McKee and colleagues proposed a staging scheme for characterizing the severity of the hyperphosphorylated tau (p-tau) pathology, the McKee CTE staging scheme. The staging scheme defined four pathological stages of CTE, stages I(mild)-IV(severe), based on the density and regional deposition of p-tau...
August 11, 2020: Acta Neuropathologica
John J McNeil, Peter Gibbs, Suzanne G Orchard, Jessica E Lockery, Wendy B Bernstein, Yin Cao, Leslie Ford, Andrew Haydon, Brenda Kirpach, Finlay Macrae, Catriona McLean, Jeremy Millar, Anne M Murray, Mark R Nelson, Galina Polekhina, Christopher M Reid, Ellen Richmond, Luz Maria Rodríguez, Raj C Shah, Jeanne Tie, Asad Umar, G J van Londen, Kathlyn Ronaldson, Rory Wolfe, Robyn L Woods, John Zalcberg, Andrew T Chan
BACKGROUND: ASPirin in Reducing Events in the Elderly (ASPREE), a randomized double-blind placebo-controlled trial (RCT) of daily low-dose aspirin (100 mg) in older adults, showed an increase in all-cause mortality, primarily due to cancer. In contrast prior RCTs, mainly involving younger individuals, demonstrated a delayed cancer benefit with aspirin. We now report a detailed analysis of cancer incidence and mortality. METHODS: 19,114 Australian and U.S. community-dwelling participants aged 70+ years (U...
August 11, 2020: Journal of the National Cancer Institute
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"