Marco L Loggia, Daniel B Chonde, Oluwaseun Akeju, Grae Arabasz, Ciprian Catana, Robert R Edwards, Elena Hill, Shirley Hsu, David Izquierdo-Garcia, Ru-Rong Ji, Misha Riley, Ajay D Wasan, Nicole R Zürcher, Daniel S Albrecht, Mark G Vangel, Bruce R Rosen, Vitaly Napadow, Jacob M Hooker
Although substantial evidence has established that microglia and astrocytes play a key role in the establishment and maintenance of persistent pain in animal models, the role of glial cells in human pain disorders remains unknown. Here, using the novel technology of integrated positron emission tomography-magnetic resonance imaging and the recently developed radioligand (11)C-PBR28, we show increased brain levels of the translocator protein (TSPO), a marker of glial activation, in patients with chronic low back pain...
March 2015: Brain