Yongkang Chen, Xiaohong Li, Fengyang Han, Beihong Ji, Yuan Li, Jingjing Yan, Min Wang, Jun Fan, Shuye Zhang, Lu Lu, Peng Zou
Human enteroviruses are the major pathogens causing hand-foot-and-mouth disease in infants and young children throughout the world, and infection with enterovirus is also associated with severe complications, such as aseptic meningitis and myocarditis. However, there are no antiviral drugs available to treat enteroviruses infection at present. In this study, we found that 4'-fluorouridine (4'-FlU), a nucleoside analog with low cytotoxicity, exhibited broad-spectrum activity against infections of multiple enteroviruses with EC50 values at low micromolar levels, including coxsackievirus A10 (CV-A10), CV-A16, CV-A6, CV-A7, CV-B3, enterovirus A71 (EV-A71), EV-A89, EV-D68, and echovirus 6...
April 30, 2024: Antimicrobial Agents and Chemotherapy