Dimitrius Santiago P S F Guimarães, Ninon M F Barrios, André Gustavo de Oliveira, David Rizo-Roca, Maxence Jollet, Jonathon A B Smith, Thiago R Araujo, Marcos Vinicius da Cruz, Emilio Marconato, Sandro M Hirabara, André S Vieira, Anna Krook, Juleen R Zierath, Leonardo R Silveira
BACKGROUND: The maintenance of skeletal muscle plasticity upon changes in the environment, nutrient supply, and exercise depends on regulatory mechanisms that couple structural and metabolic adaptations. The mechanisms that interconnect both processes at the transcriptional level remain underexplored. Nr2f6, a nuclear receptor, regulates metabolism and cell differentiation in peripheral tissues. However, its role in the skeletal muscle is still elusive. Here, we aimed to investigate the effects of Nr2f6 modulation on muscle biology in vivo and in vitro...
April 29, 2024: Journal of Cachexia, Sarcopenia and Muscle