Qiming Gao, Pinfei Ni, Yilin Wang, Peiyun Huo, Xiaojie Zhang, Sihan Wang, Fuyao Xiao, Yixuan Li, Wei Feng, Juntao Yuan, Teng Zhang, Qiang Li, Boyu Fan, Yuhao Kan, Zhirui Li, Yimiao Qi, Junfei Xing, Zhenghong Yang, Haixiao Cheng, Xinran Gao, Xiaoyan Feng, Ming Xue, Yang Liu, Yumin Luo, Zhongbing Lu, Yuming Zhao
Choline acetyltransferase (ChAT)-positive neurons in neural stem cell (NSC) niches can evoke adult neurogenesis (AN) and restore impaired brain function after injury, such as acute ischemic stroke (AIS). However, the relevant mechanism by which ChAT+ neurons develop in NSC niches is poorly understood. Our RNA-seq analysis revealed that dimethylarginine dimethylaminohydrolase 1 (DDAH1), a hydrolase for asymmetric N G , N G -dimethylarginine (ADMA), regulated genes responsible for the synthesis and transportation of acetylcholine (ACh) ( Chat , Slc5a7 and Slc18a3 ) after stroke insult...
May 2024: Acta Pharmaceutica Sinica. B