Vicky Goh, Susan Mallett, Victor Boulter, Robert Glynne-Jones, Saif Khan, Sarah Lessels, Dominic Patel, Davide Prezzi, Manuel Rodriguez-Justo, Stuart A Taylor, Richard Beable, Margaret Betts, David J Breen, Ingrid Britton, John Brush, Peter Correa, Nicholas Dodds, Joanna Dunlop, Sofia Gourtsoyianni, Nyree Griffin, Antony Higginson, Andrew Lowe, Andrew Slater, Madeline Strugnell, Damian Tolan, Ian Zealley, Steve Halligan
OBJECTIVE: Improving prognostication to direct personalised therapy remains an unmet need. This study prospectively investigated promising CT, genetic, and immunohistochemical markers to improve the prediction of colorectal cancer recurrence. MATERIAL AND METHODS: This multicentre trial (ISRCTN 95037515) recruited patients with primary colorectal cancer undergoing CT staging from 13 hospitals. Follow-up identified cancer recurrence and death. A baseline model for cancer recurrence at 3 years was developed from pre-specified clinicopathological variables (age, sex, tumour-node stage, tumour size, location, extramural venous invasion, and treatment)...
June 5, 2024: European Radiology