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REVIEW
Xingyu Li, Xiaojing Shen, Weiwei Jiang, Yongkai Xi, Song Li
Emerging contaminants (ECs) are a diverse group of unregulated pollutants increasingly present in the environment. These contaminants, including pharmaceuticals, personal care products, endocrine disruptors, and industrial chemicals, can enter the environment through various pathways and persist, accumulating in the food chain and posing risks to ecosystems and human health. This comprehensive review examines the chemical characteristics, sources, and varieties of ECs. It critically evaluates the current understanding of their environmental and health impacts, highlighting recent advancements and challenges in detection and analysis...
May 2, 2024: Ecotoxicology and Environmental Safety
#2
REVIEW
Zohreh Salimi, Mehdi Afsharinasab, Mehdi Rostami, Yaser Eshaghi Milasi, Seyedeh Fatemeh Mousavi Ezmareh, Fariba Sakhaei, Maryam Mohammad-Sadeghipour, Sayyed Mehdi Rasooli Manesh, Zatollah Asemi
The concentration of iron is tightly regulated, making it an essential element. Various cellular processes in the body rely on iron, such as oxygen sensing, oxygen transport, electron transfer, and DNA synthesis. Iron excess can be toxic because it participates in redox reactions that catalyze the production of reactive oxygen species and elevate oxidative stress. Iron chelators are chemically diverse; they can coordinate six ligands in an octagonal sequence. Because of the ability of chelators to trap essential metals, including iron, they may be involved in diseases caused by oxidative stress, such as infectious diseases, cardiovascular diseases, neurodegenerative diseases, and cancer...
May 2024: Annals of Medicine and Surgery
#3
Hasaan Ahmed, Mahmoud Ismayl, Anirudh Palicherla, Joshua May, Andrew M Goldsweig, Joseph Thirumalareddy
INTRODUCTION AND IMPORTANCE: While vaping has increased significantly among young individuals, the effects of vape aerosol constituents on cardiac electrophysiological dynamics remain unknown. CASE PRESENTATION: A 22-year-old female with a history of energy vaping presented with cardiac arrest. Found to have no pulse, CPR was started and an initial rhythm of ventricular tachycardia was obtained. Shock was administered with a follow-up rhythm of ventricular fibrillation...
May 2024: Annals of Medicine and Surgery
#4
JOURNAL ARTICLE
Pavla Vrabcová, Petr Scholz, Ivica Linderová, Hana Kotoučková
The economic recovery of the tourism industry after the Covid-19 pandemic to find modern and efficient trends to increase profitability is accompanied by the adoption of comprehensive accommodation approaches towards resilience and environmental sustainability. The research aims at the application of environmental management elements and measures in all types of accommodation facilities in the Czech Republic (n1 = 1,016). A qualitative focus group method complemented the quantitative research using correspondence analysis, Levene's, Kruskal-Wallis, and Tukey's HSD tests (n2 = 9 + moderator)...
2024: PloS One
#5
JOURNAL ARTICLE
T Bagheri, M J Fatemi, S Hoveidamanesh, T Ghadimi, O Mahboubi, M Asgari, H Rahbar, M Momeni
Burn accidents continue to cause severe physical, psychological and economic damage to individuals and communities, especially in low- and middle-income countries. The present study was designed and conducted to investigate the epidemiology and identify the causes/mechanisms of burns in Iran, focusing on the economic, social and educational status of patients. This is a survey study that was performed from August 2016 to October 2017 on patients referred to Shahid Motahari University Hospital in Tehran. Samples included all patients whose parents or children were able to answer the questions...
June 2023: Annals of Burns and Fire Disasters
#6
JOURNAL ARTICLE
Fenoon Abdullah Aljohani, Bakriah Yahyaa Alzubaidi, Reem Hamdan Al-Rafdan, Hanan Mutiq Alblawi, Rama Hani Alrehayan, Ghada Abdulrahman Alsenan, Hadeil Salman Almohaya, Mona Mohamed Taha
OBJECTIVES: The prevalence of e-cigarettes is significantly increasing among adults as an alternative method to tobacco smoking. However, the chemical products of e-cigarettes have an influence on human general health. Therefore, this study aims to investigate the association between e-cigarette use and psychological distress as well as participation in daily activities among adults in Riyadh, Saudi Arabia. It also evaluates the demographic profile and usage patterns of e-cigarette users...
2024: Frontiers in Psychiatry
#7
JOURNAL ARTICLE
Dwi Fitri Yudiantoro, Bambang Irawan, Intan Paramita Haty, Setia Pambudi, Shalva Tmy, Arum Suproborini, Sekar Bawaningrum, Paramita Ismaya, Mirzam Abdurrachman, Isao Takashima, Temmy Wikaningrum, Noor Cahyo Aryanto
The pH of Mount Ijen crater water is 0-2, resulting in water that is acidic and sulfurous. A fault near the Mount Ijen Crater causes seepage so that acidic water flows into the Banyupait River. Chemical elements and heavy metals originating from the river pollute groundwater and plants. As a result, people around the river consume heavy metals. This research aims to determine the quality of river water and groundwater, as well as determine community factors that are susceptible to dental fluorosis. The methodology used is field mapping and laboratory analysis...
April 2024: Water Science and Technology: a Journal of the International Association on Water Pollution Research
#8
JOURNAL ARTICLE
Prakhar Varshney, Phool Chandra
In vivo investigations are much more complex than trials conducted in a test tube; the results sometimes aren't as illuminating and could raise more questions than answers. Preclinical data projection into clinical truth is a transcriptional science that remains a compelling trial in drug development. Preclinical in vivo and in vitro education is important in novel drug's non-violent or active growth. Pharmacokinetic and metabolic research is necessary to better understand the chemical and biological effects of medicines and their metabolites...
April 25, 2024: Current Drug Discovery Technologies
#9
JOURNAL ARTICLE
Genny Carrillo, Nina I Mendez-Dominguez, Maria Elena Acosta Enriquez, Javier Morán-Martínez
The increase in the popularity and use of electronic cigarettes (e-cigarettes) has consistently risen worldwide and has become associated with adverse health outcomes. This study has identified the attitudes and perceptions of undergraduate students who vape in three universities in Mexico. A cross-sectional study involving 495 participants was conducted using a survey from October to December 2023. Three universities in different states in Mexico collaborated with colleges in Yucatan, Durango, and Nuevo Leon, Mexico...
April 10, 2024: International Journal of Environmental Research and Public Health
#10
JOURNAL ARTICLE
Kathryn S Tomsho, Marlee R Quinn, Gary Adamkiewicz, Tamarra James-Todd
BACKGROUND: Substantial evidence exists linking phthalate exposure to adverse reproductive health outcomes. Current US federal regulations of consumer product chemicals place the onus on individuals to mitigate their exposure to phthalates, with assumptions of sufficient environmental health literacy (EHL). Few validated scales for people of reproductive age exist to evaluate phthalate-specific EHL. OBJECTIVES: Our objective is to develop a multidimensional scale characterizing latent factors of phthalate knowledge, risk perception, and self-efficacy to inform individual-level interventions for reducing phthalate exposure...
April 2024: Environmental Health Perspectives
#11
JOURNAL ARTICLE
Alina Cernasev, Amy Hall, Stacey Thomas-Gooch, Devin Scott
Preparing the next generation of pharmacists to succeed in practice and provide premier care starts with ensuring pharmacy education standards are met and align with innovative practices and that education incorporates topics that are important to promoting health. For example, recent reports link endocrine disrupting chemicals (EDCs) to numerous diseases such as reproductive disorders, metabolic diseases, and developmental abnormalities. Considering the suboptimal awareness and knowledge about EDCs, it is imperative to provide public health education through a pharmacy curriculum...
March 26, 2024: Pharmacy (Basel, Switzerland)
#12
JOURNAL ARTICLE
Joseph W Scott, J Jordan Steel
There are places on earth that are considered to possess extreme physico-chemical characteristics as they relate to life. Surprisingly, there are microbes that have adapted various strategies that enable them to form robust communities in these environments. The microbes that live in these environments, called extremophiles, are described as being thermophilic, psychrophilic, halophilic, acidophilic, alkaliphilic, barophilic, and so on. Given that extremophiles were not discovered until relatively recently due to a view point that the environments in which they inhabited were not conducive to life, it is reasonable to conclude that the concept of extremophiles may be hard to grasp for students...
April 25, 2024: Journal of Microbiology & Biology Education: JMBE
#13
JOURNAL ARTICLE
Parvin Shafiei-Moghaddam, Katayoun Jahangiri, Nemat Hassani
INTRODUCTION: In recent decades, an increase in natural disasters has led to the Natech events occurrence, which are technological accidents triggered by natural hazards. This study aims to assess the risk of chemical release of the H2 S toxic gas following an earthquake from the refinery. METHOD: The Natech risk assessment was carried out in potential earthquake risk scenarios via a semi-quantitative method using Rapid-N software. The reference scenario was obtained using the Australian SMUG Model, which has presented precise prioritization...
April 30, 2024: Heliyon
#14
JOURNAL ARTICLE
Josué A Benjamín-Rivera, Mariela Pérez Otero, Arthur D Tinoco
The two-week protein biochemistry experience described herein focuses on reinforcing key biochemical concepts and achieving significant learning domain accomplishments for students (Content Knowledge, Logical Mathematical Reasoning, Visualization, Information Literacy, and Knowledge Integration) and valuable teaching opportunities for instructors. The experience encompasses an exploration of the transport protein serum transferrin as an important regulator of Fe(III) biochemistry and incorporates techniques to assess protein-metal stoichiometry and protein stability and to perform molecular visualization...
April 9, 2024: Journal of Chemical Education
#15
JOURNAL ARTICLE
Joshua E Lane, Derrick Tin, Ameena Ali, Gregory Ciottone
INTRODUCTION: The threat of chemical, biological, radiologic, nuclear, and explosive (CBRNe) terrorist attacks has increased over time. The need for rapid and effective responses to such attacks is paramount. Effective medical counter-measures to CBRNe events are critical and training for such may effectively occur early in physician training. While some medical specialties are more involved than others, counter-terrorism medicine (CTM) spans all medical specialties. METHODS: All United States allopathic medical schools were examined via online curriculums and queries for academic content related to CBRNe and terrorist medical counter-measures...
April 23, 2024: Prehospital and Disaster Medicine
#16
JOURNAL ARTICLE
McKenzi Thompson, Jasmin Eatman, Anne L Dunlop, Dana Boyd Barr, Kurunthachalam Kannan, Elizabeth J Corwin, P Barry Ryan, Parinya Panuwet, Volha Yakimavets, Kaitlin R Taibl, Youran Tan, Donghai Liang, Stephanie M Eick
BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) are man-made chemicals that are slow to break down in the environment and widely detected in humans. Epidemiological evidence suggests that prenatal exposure to perfluorooctanoic acid (PFOA), a legacy PFAS, is linked to gestational hypertension and preeclampsia. However, the relationship between other PFAS, which are structurally similar, and these outcomes remains largely understudied, despite biologic plausibility. Here, we examined associations between serum PFAS mixtures in relation to hypertensive disorders of pregnancy within a birth cohort of African Americans...
April 15, 2024: Chemosphere
#17
JOURNAL ARTICLE
Victoria Fruh, Amelia K Wesselink, Samantha Schildroth, Traci N Bethea, Ruth J Geller, Antonia M Calafat, Brent A Coull, Ganesa Wegienka, Quaker E Harmon, Donna D Baird, Lauren A Wise, Birgit Claus Henn
BACKGROUND: Results of studies investigating associations between individual endocrine-disrupting chemicals (EDCs) and incidence of uterine leiomyomata (UL), a hormone-dependent gynecological condition, have been inconsistent. However, few studies have evaluated simultaneous exposure to a mixture of EDCs with UL incidence. METHODS: We conducted a case-cohort analysis (n=708) of data from the Study of the Environment, Lifestyle and Fibroids (SELF), a prospective cohort study...
April 15, 2024: Chemosphere
#18
JOURNAL ARTICLE
Jones Anderson Monteiro Siqueira, Dielle Monteiro Teixeira, Guilherme Junior Leite da Piedade, Cintya de Oliveira Souza, Tuane Carolina Ferreira Moura, Marcia de Nazaré Miranda Bahia, Danielle Murici Brasiliense, Denise Suéllen Amorim de Sousa Santos, Lena Lillian Canto de Sa Morais, Dorotéa de Fátima Lobato da Silva, Bruno Santana Carneiro, Kenny da Costa Pinheiro, Edivaldo Costa Sousa Junior, Clístenes Pamplona Catete, Ricardo José de Paula Souza E Guimarães, James Lima Ferreira, Wanderley Dias das Chagas Junior, Raiana Scerni Machado, Fernando Neto Tavares, Hugo Reis Resque, Patrícia Dos Santos Lobo, Sylvia de Fátima Dos Santos Guerra, Luana Silva Soares, Luciana Damascena da Silva, Yvone Benchimol Gabbay
AIMS: The present study aimed to use a conventional and metagenomic approach to investigate the microbiological diversity of water bodies in a network of drainage channels and rivers located in the central area of the city of Belém, Northern Brazil, which is considered one of the largest cities in the Brazilian Amazon. METHODS AND RESULTS: In eight of the analyzed points, both bacterial and viral microbiological indicators of environmental contamination, the physical-chemical and metals were assessed...
April 16, 2024: Journal of Applied Microbiology
#19
JOURNAL ARTICLE
Hai-Wei Liang, Hannu Koistinen, Emily S Barrett, Xiaoshuang Xun, Qing Yin, Kurunthachalam Kannan, Nora K Moog, Carla Ng, Thomas G O'Connor, Rich Miller, Jennifer J Adibi
BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) are widely detected in pregnant women and associated with adverse outcomes related to impaired placental function. Human chorionic gonadotropin (hCG) is a dimeric glycoprotein hormone that can indicate placental toxicity. OBJECTIVES: Our aim was to quantify the association of serum PFAS with placental hCG, measured as an intact molecule (hCG), as free alpha-(<mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mtext>hCG</mml:mtext><mml:mi>α</mml:mi></mml:mrow></mml:math>) and beta-subunits (<mml:math xmlns:mml="https://www...
April 2024: Environmental Health Perspectives
#20
REVIEW
Jun Ohata
Chemical tools and principles have become central to biological and medical research/applications by leveraging a range of classical organic chemistry reactions. Friedel-Crafts alkylation and acylation are arguably some of the most well-known and used synthetic methods for the preparation of small molecules but their use in biological and medical fields is relatively less frequent than the other reactions, possibly owing to the notion of their plausible incompatibility with biological systems. This review demonstrates advances in Friedel-Crafts alkylation and acylation reactions in a variety of biomolecular chemistry fields...
April 16, 2024: Organic & Biomolecular Chemistry
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