Cristiani Cortez Mendes, Bruna Lancia Zampieri, Lidia Maria Rebolho Batista Arantes, Matias Eliseo Melendez, Joice Matos Biselli, André Lopes Carvalho, Marcos Nogueira Eberlin, Maria Francesca Riccio, Hélio Vannucchi, Valdemir Melechco Carvalho, Eny Maria Goloni-Bertollo, Érika Cristina Pavarino
Down syndrome (DS) is the most common chromosomal disorder, resulting from the failure of normal chromosome 21 segregation. Studies have suggested that impairments within the one-carbon metabolic pathway can be of relevance for the global genome instability observed in mothers of individuals with DS. Based on the association between global DNA hypomethylation, genome instability, and impairments within the one-carbon metabolic pathway, the present study aimed to identify possible predictors, within the one-carbon metabolism, of global DNA methylation, measured by methylation patterns of LINE-1 and Alu repetitive sequences, in mothers of individuals with DS and mothers of individuals without the syndrome...
August 19, 2021: Human Cell