Kazuki M Matsuda, Hirohito Kotani, Kei Yamaguchi, Taishi Okumura, Eriko Fukuda, Masanori Kono, Teruyoshi Hisamoto, Ruriko Kawanabe, Yuta Norimatsu, Ai Kuzumi, Maiko Fukayama, Takemichi Fukasawa, Satoshi Ebata, Asako Yoshizaki-Ogawa, Tomohisa Okamura, Hirofumi Shoda, Keishi Fujio, Naoki Goshima, Shinichi Sato, Ayumi Yoshizaki
Cutaneous arteritis (CA) is a single-organ vasculitis that exclusively affects the small to medium-sized arteries of the skin. Diagnosis depends on a histological investigation with skin biopsy, which could be burdensome for both patients and clinicians. Moreover, the pathogenesis of CA remains unstudied, and treatment has not yet been established. Herein, we applied our proteome-wide autoantibody screening method to explore autoantibodies in the serum of CA patients. As a result, anti-transcobalamin receptor (TCblR) antibodies (Abs) were specifically detected in 24% of CA patients...
February 2023: Journal of Autoimmunity