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JOURNAL ARTICLE
Noor Hidayatul Aini Suaini, Koh Qi Yi, Toh Jia Ying, Victoria X Soriano, Marjorelee Tabaldo Colega, Carmen Riggioni, Mohammad Shaheryar Furqan, Pang Wei Wei, Evelyn Loo Xiu Ling, Hugo P Van Bever, Shek Pei-Chi Lynette, Anne Eng Neo Goh, Oon Hoe Teoh, Tan Kok Hian, Lee Bee Wah, Keith M Godfrey, Mary Foong-Fong Chong, Elizabeth Huiwen Tham
BACKGROUND: We previously reported that delayed allergenic food introduction in infancy did not increase food allergy risk until age 4 years within our prospective cohort. However, it remains unclear whether other aspects of maternal or infant diet play roles in the development of childhood food allergy. OBJECTIVE: Here we examined the relationship between maternal pregnancy and infant dietary patterns and the development of food allergies until age 8 years. METHODS: Among 1152 Singapore GUSTO study mother-infant dyads, the infant's diet was ascertained using food frequency questionnaires at 18 months (M)...
May 11, 2024: Journal of Nutrition
#2
JOURNAL ARTICLE
Zahraa Elrasheed Ali, Abdelrahim Elameen, Fatima A Fadul, Rawan R Babikir, Ahmed H Arbab
BACKGROUND: Cow's milk protein allergy is the most frequent type of food allergy in newborns and young children. It affects numerous body systems. A community pharmacist possessing adequate knowledge and appropriate practices is crucial for the management of the disease. OBJECTIVES: : This study aimed to assess the knowledge and attitude of community pharmacists toward the complications and treatment of cow milk protein allergy. METHODS: A descriptive cross-sectional study was conducted among 332 randomly selected community pharmacists in the Capital of Sudan (Khartoum state)...
2024: Integrated Pharmacy Research and Practice
#3
REVIEW
Julia Kuźniar, Patrycja Kozubek, Krzysztof Gomułka
Food allergy (FA) has become a common global public health issue, with a growing prevalence in the modern world and a significant impact on the lives of patients, their families, and caregivers. It affects every area of life and is associated with elevated costs. Food allergy is an adverse immune reaction that occurs in response to a given food. The symptoms vary from mild to severe and can lead to anaphylaxis. This is why it is important to focus on the factors influencing the occurrence of food allergies, specific diagnostic methods, effective therapies, and especially prevention...
April 27, 2024: Nutrients
#4
JOURNAL ARTICLE
Solveig Røisgård, Anna Nopp, Anna Lindam, Caroline A Nilsson, Christina E West
BACKGROUND: The basophil activation test is an emerging clinical tool in the diagnosis of cow's milk allergy (CMA). The aim was to assess the association between the basophil allergen threshold sensitivity to the major milk protein casein (casein-specific CD-sens), the levels of milk- and casein-specific Immunoglobulin E antibodies (IgE-ab), and the severity of allergic reactions at milk challenges. METHODS: We enrolled 34 patients aged 5-15 (median 9) years who underwent a double-blind placebo-controlled milk-challenge (DBPCMC) as screening before inclusion in an oral immunotherapy study for CMA...
May 2024: Immunity, Inflammation and Disease
#5
JOURNAL ARTICLE
Vanessa Cristina de Castro Rodrigues, Thaysa Maués Cezar, Camila Leonel Mendes de Abreu, Adriana Sanudo, Mauro Batista de Morais
INTRODUCTION AND OBJECTIVES: Food allergy has several negative nutritional consequences and may persist beyond the first year of lives. This study aimed to assess the role of a complete oral amino acid-based supplement in the diet of children on cow's milk protein elimination diet because of food allergy. MATERIALS AND METHODS: This study included two groups of children aged 1-5 years paired by age and socioeconomic status: (1) study group, on cow's milk protein elimination diet plus an oral amino acid-based supplement, and (2) control group, on cow's milk protein elimination diet...
2024: Allergologia et Immunopathologia
#6
JOURNAL ARTICLE
Antonio Bognanni, Alessandro Fiocchi, Stefania Arasi, Derek K Chu, Ignacio Ansotegui, Amal H Assa'ad, Sami L Bahna, Roberto Berni Canani, Martin Bozzola, Lamia Dahdah, Christophe Dupont, Piotr Dziechciarz, Motohiro Ebisawa, Ramon T Firmino, Alexandro Chu, Elena Galli, Andrea Horvath, Rose Kamenwa, Gideon Lack, Haiqi Li, Alberto Martelli, Anna Nowak-Węgrzyn, Nikolaos G Papadopoulos, Ruby Pawankar, Yetiani Roldan, Maria Said, Mario Sánchez-Borges, Raanan Shamir, Jonathan M Spergel, Hania Szajewska, Luigi Terracciano, Yvan Vandenplas, Carina Venter, Siw Waffenschmidt, Susan Waserman, Amena Warner, Gary W K Wong, Holger J Schünemann, Jan L Brozek
BACKGROUND: Cow's milk allergy (CMA) is the most common food allergy in infants. The replacement with specialized formulas is an established clinical approach to ensure adequate growth and minimize the risk of severe allergic reactions when breastfeeding is not possible. Still, given the availability of multiple options, such as extensively hydrolyzed cow's milk protein formula (eHF-CM), amino acid formula (AAF), hydrolyzed rice formula (HRF) and soy formulas (SF), there is some uncertainty as to the most suitable choice with respect to health outcomes...
April 2024: World Allergy Organization Journal
#7
JOURNAL ARTICLE
Tetsuhiro Sakihara, Kenta Otsuji, Yohei Arakaki, Kazuya Hamada, Shiro Sugiura, Komei Ito
BACKGROUND: Early supplementation and subsequent discontinuation of cow's milk formula (CMF) may increase the risk of cow's milk allergy in breast-fed infants, but little is known about the relationship between continuous CMF ingestion and cow's milk protein-specific immunoglobulin production. OBJECTIVE: This study aimed to clarify the aforesaid relationship in cow's milk-sensitized infants. METHODS: Using data from a randomized controlled trial of a Japanese birth cohort, we performed a subgroup analysis of participants who had ingested CMF in the first 3 days of life and exhibited a positive skin prick test response to cow's milk at age 6 months...
August 2024: J Allergy Clin Immunol Glob
#8
JOURNAL ARTICLE
Josefin Ullberg, Disa Ullberg, Mareike Fech-Bormann, Ulrika L Fagerberg
BACKGROUND: Food protein-induced enterocolitis syndrome (FPIES), a non-immunoglobulin E (IgE)-mediated allergy, primarily affects infants and young children. Whether and when tolerance develops seems to vary among populations and trigger foods. OBJECTIVE: This study aimed to evaluate tolerance development and its assessment in a Swedish cohort. METHODS: This was a prospective follow-up study of a Swedish cohort of 113 children, followed at 25 pediatric departments, with acute FPIES...
April 27, 2024: Journal of Allergy and Clinical Immunology in Practice
#9
JOURNAL ARTICLE
Cynthia Haddad, Ankona Banerjee, Joshua Eubanks, Ruchit Rana, Nicholas L Rider, Lisa Pompeii, Sara Anvari
BACKGROUND: Food protein-induced enterocolitis syndrome (FPIES) is being increasingly recognized as a non-IgE mediated food allergy; however, it remains unclear if and how the presentation, diagnosis and management of this disease has changed in recent years. OBJECTIVE: To reappraise the FPIES cohort at a large United States pediatric tertiary referral center. METHODS: We performed a retrospective chart review of pediatric FPIES patients (ICD-10: K52...
April 27, 2024: Journal of Allergy and Clinical Immunology in Practice
#10
JOURNAL ARTICLE
Ariadni Kourkouli, Nikolaos Thomaidis, Marilena Dasenaki, Athina Markou
Milk is the most consumed liquid food in the world due to its high nutritional value and relatively low cost, characteristics that make it vulnerable to adulteration. One of the most common types of milk adulteration involves the undeclared addition of cow's milk to milk from other mammalian species, such as goats, sheep, buffalo or donkeys. The incidence of such adulteration not only causes a crisis in terms of commercial market and consumer uncertainty but also poses a risk to public health, as allergies can be triggered by proteins in undeclared cow's milk...
April 17, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#11
JOURNAL ARTICLE
César Galván Calle, Cecilia Díaz-Vásquez, Wilmer Córdova-Calderón, Juan Gómez de la Torre, Edgar Matos-Benavides, Crhistian Toribio-Dionicio
BACKGROUND: Cow's milk protein allergy (CMPA) remains relatively understudied in Latin America. METHODS: In this observational study, we enrolled 64 patients with a median age of 3 months, of whom 60% were male. Patients included had a history of IgE-mediated reactions with IgE sensitization or non-IgE-mediated reactions or symptoms following exposure to cow's milk. They underwent skin prick test, ImmunoCAP, fecal calprotectin (FC), and fecal eosinophil-derived neurotoxin (EDN), in addition to double-blinded placebo-controlled oral food challenges (DBPCFC), with clinical evolution and tolerance acquisition observed over 1 year...
April 2024: Immunity, Inflammation and Disease
#12
JOURNAL ARTICLE
Kim L Tran, Elizabeth L Wisner, George M Jeha, Luke A Wall
Food protein-induced allergic proctocolitis (FPIAP) is a non-IgE-mediated allergic condition that presents with hematochezia in otherwise healthy infants. It is most commonly induced by cow's milk protein via breast milk or formula. The prognosis for FPIAP is generally considered favorable with most infants achieving symptomatic resolution after diet modification. Most infants go on to tolerate the offending foods by 1-3 years of age. Over 8 years at our institution, five patients were identified and noted to have FPIAP to cow's milk during infancy with subsequent development of IgE-mediated allergic reaction to cow's milk and other foods...
2024: Front Allergy
#13
JOURNAL ARTICLE
Navaphan Rattanapakdeekul, Jinthana Lapirattanakul, Orada Tosrisawatkasem, Rudee Surarit, Apiwan Smutkeeree
INTRODUCTION: When infants cannot consume breast milk, the most commonly available alternative milk formula is cow milk-based. Due to a rise in the prevalence of cow milk protein allergy (CMPA) among children, this study aimed to assess the biofilm formation and acidogenicity of cow milk-based formulas as well as milk formulas suggested for children with CMPA. METHODS: Cow milk-based formulas with 0%, 10%, or 18% sucrose added, partially hydrolyzed formula (pHF), extensively hydrolyzed formula (eHF), amino acid-based formula (AAF), and soy-based formulas with 0%, or 11% sucrose added were evaluated...
April 18, 2024: Caries Research
#14
JOURNAL ARTICLE
Qiang Xie, Ke Xu, Ziqing Sang, Dan Luo, Chen Chen, Wenhui Fu, Wentong Xue
Casein (CN) is the primary allergenic protein in cow's milk, contributing to the worldwide escalating prevalence of food allergies. However, there remains limited knowledge regarding the effect of structural modifications on CN allergenicity. Herein, we prepared three modified CNs (mCN), including sodium dodecyl sulfate and dithiothreitol-induced linear CN (LCN), transglutaminase-cross-linked CN (TCN), and glucose-glycated CN (GCN). The electrophoresis results indicated widespread protein aggregation among mCN, causing variations in their molecular weights...
April 17, 2024: Journal of Agricultural and Food Chemistry
#15
JOURNAL ARTICLE
Lijuan Sun, Shiwen Han, Sufang Duan, Like Mao, Fang Li, Zhenhua Tu, Huilian Che
SCOPE: In cases where breast milk is unavailable or inadequate, hydrolyzed infant formula is recommended as the primary alternative. The aim of this study is to assess and compare the allergenicity of two partially hydrolyzed whey-based formulas (PHF-Ws) using serum samples from patients with cow's milk allergy (CMA). METHODS AND RESULTS: LC-MS/MS technology is used to investigate the peptide distribution in both samples. The immunoreactivity of two PHF-Ws in 27 serum samples from 50 Chinese infants (02 years) with CMA is analyzed...
April 11, 2024: Molecular Nutrition & Food Research
#16
JOURNAL ARTICLE
Isabella Fakih-Botero, Maria Camila Cerchiaro-Mejia, Maria Juliana Rusinque, María Alejandra Palacios-Ariza, Clara Eugenia Plata-Garcia, Stephania Peña-Hernández
OBJECTIVE: To identify the out-of-pocket expenses and parent-reported quality of life (QoL) of children with a diagnosis of cow's milk protein allergy (CMPA) between the ages of 0 and 5 using the Food Allergy Quality of Life Questionnaire - Parent Form. METHODS: A cross-sectional study was conducted in two tertiary care centers in Bogotá. Demographic, medical information, and QoL scores were collected by parental interview. We carried out a cost-of-illness analysis based on self-reported out-of-pocket expenses attributed to the treatment as a whole and the family's monthly income...
April 8, 2024: Journal of Pediatric Gastroenterology and Nutrition
#17
REVIEW
Xiaoxu Li, Tingchao He, Sufang Duan, Jinghong Liang, Gang Feng, Fang Li, Zhenyu Shen, Wenhui Ye, Biao Liu, Bibo Jiang, Yujing Chen, Nan Liu, Ignatius Man-Yau Szeto, Li Cai
Despite the widely recommended usage of partially or extensively hydrolyzed milk protein formula (PHF or EHF) for preventing allergic diseases (ADs), clinical studies have been inconclusive regarding their efficacy compared with cow's milk formula (CMF) or breast milk (BM). We aimed to systematically evaluate the effects of PHF or EHF versus CMF or BM on the risk of ADs (cow's milk allergy, allergic rhinitis, eczema, asthma, wheeze, food allergy, and sensitization) in children. We searched PubMed, Embase, Cochrane Library, and Web of Science for clinical trials published from inception to October 21st, 2022...
April 3, 2024: Advances in Nutrition
#18
JOURNAL ARTICLE
Jessica V Baran, Jerry M Brown, Andrew A Farrar, Lea V Oliveros, Jesse Beacker, Luke Lamos, Jared Florio, Abigail L Fabbrini, Michael J Wilsey
BACKGROUND: In 2022, the United States experienced a national shortage of infant formula due to a global supply chain crisis and a large-scale domestic formula recall. The existing literature on healthcare providers' (HCPs) clinical decision-making during formula shortages is limited. This study aims to analyze the factors influencing pediatric HCP clinical decision-making when switching between amino acid formulas (AAF) for managing cow's milk protein allergy (CMPA) in infants under 24 months of age during an unprecedented national formula shortage...
2024: Frontiers in Pediatrics
#19
JOURNAL ARTICLE
Zhi-Dan Yu, Ling-Ling Yue, Zi-Hui Wang, Rui-Zi Wang, Li-Feng Li, Wan-Cun Zhang, Xiao-Qin Li
OBJECTIVES: To explore the changes in gut microbiota and levels of short-chain fatty acids (SCFA) in infants with cow's milk protein allergy (CMPA), and to clarify their role in CMPA. METHODS: A total of 25 infants diagnosed with CMPA at Children's Hospital Affiliated to Zhengzhou University from August 2019 to August 2020 were enrolled as the CMPA group, and 25 healthy infants were selected as the control group. Fecal samples (200 mg) were collected from both groups and subjected to 16S rDNA high-throughput sequencing technology and liquid chromatography-mass spectrometry to analyze the changes in gut microbial composition and metabolites...
March 15, 2024: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
#20
JOURNAL ARTICLE
Lin Hou, Zi-Jun Ma, Shuang Chao, Zhong-Yuan Li, Yu Zhang, Yi-Jian Liu, Jun-Hong Zhang, Wen-Yan Wu, Shan-Ya-Mei Huang, Jie Liu
OBJECTIVES: To explore the risk factors associated with cow's milk protein allergy (CMPA) in infants. METHODS: This study was a multicenter prospective nested case-control study conducted in seven medical centers in Beijing, China. Infants aged 0-12 months were included, with 200 cases of CMPA infants and 799 control infants without CMPA. Univariate and multivariate logistic regression analyses were used to investigate the risk factors for the occurrence of CMPA...
March 15, 2024: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
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