Juliana C S Chaves, Laura A Milton, Romal Stewart, Tarosi Senapati, Laura M Rantanen, Joanna M Wasielewska, Serine Lee, Damián Hernández, Lachlan McInnes, Hazel Quek, Alice Pébay, Paul S Donnelly, Anthony R White, Lotta E Oikari
SARS-CoV-2 spike proteins have been shown to cross the blood-brain barrier (BBB) in mice and affect the integrity of human BBB cell models. However, the effects of SARS-CoV-2 spike proteins in relation to sporadic, late onset, Alzheimer's disease (AD) risk have not been extensively investigated. Here we characterized the individual and combined effects of SARS-CoV-2 spike protein subunits S1 RBD, S1 and S2 on BBB cell types (induced brain endothelial-like cells (iBECs) and astrocytes (iAstrocytes)) generated from induced pluripotent stem cells (iPSCs) harboring low (APOE3 carrier) or high (APOE4 carrier) relative Alzheimer's risk...
May 21, 2024: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology