Seth Lieberman, Daniel A Rivera, Ryan Morton, Amrit Hingorani, Teresa L Southard, Lynn Johnson, Jennifer Reukauf, Ryan E Radwanski, Mingrui Zhao, Nozomi Nishimura, Oliver Bracko, Theodore H Schwartz, Chris B Schaffer
In partial onset epilepsy, seizures arise focally in the brain and often propagate. Patients frequently become refractory to medical management, leaving neurosurgery, which can cause neurologic deficits, as a primary treatment. In the cortex, focal seizures spread through horizontal connections in layers II/III, suggesting that severing these connections can block seizures while preserving function. Focal neocortical epilepsy is induced in mice, sub-surface cuts are created surrounding the seizure focus using tightly-focused femtosecond laser pulses, and electrophysiological recordings are acquired at multiple locations for 3-12 months...
May 29, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)