L D Otto-Dobos, C V Grant, A A Lahoud, O R Wilcox, L D Strehle, B R Loman, S Adarkwah Yiadom, M M Seng, N Halloy, K L G Russart, K M Carpenter, E Dawson, S D Sardesai, N O Williams, M E Gatti-Mays, D G Stover, P K Sudheendra, R Wesolowski, J K Kiecolt-Glaser, M T Bailey, R R Andridge, L M Pyter
Chemotherapy is notorious for causing behavioral side effects (e.g., cognitive decline). Notably, the gut microbiome has recently been reported to communicate with the brain to affect behavior, including cognition. Thus, the aim of this clinical longitudinal, observational study was to determine whether chemotherapy-induced disruption of the gut microbial community structure relates to cognitive decline and circulating inflammatory signals. Fecal samples, blood, and cognitive measures were collected from 77 patients with breast cancer before, during, and after chemotherapy...
May 30, 2024: Brain, Behavior, and Immunity