Mohajeet B Bhuckory, Nicharee Monkongpitukkul, Andrew Shin, Anna Kochnev Goldstein, Nathan Jensen, Sarthak V Shah, Davis Pham-Howard, Emma Butt, Roopa Dalal, Ludwig Galambos, Keith Mathieson, Theodore Kamins, Daniel Palanker
In patients with atrophic age-related macular degeneration, subretinal photovoltaic implant (PRIMA) provided visual acuity up to 20/440, matching its 100μm pixels size. Next-generation implants with smaller pixels should significantly improve the acuity. This study in rats evaluates removal of a subretinal implant, replacement with a newer device, and the resulting grating acuity in-vivo. Six weeks after the initial implantation with planar and 3-dimensional devices, the retina was re-detached, and the devices were successfully removed...
April 19, 2024: bioRxiv